159 patents
Page 4 of 8
Utility
Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
7 Dec 21
The present disclosure provides isolated nepetalactone oxidoreductase polypeptides (NORs), nepetalactol synthases (NEPSs), and related polynucleotides, engineered host cells, and cultures, as well as methods for producing NORs and NEPSs, and for using them to produce nepetalactol, nepetalactone, and dihydronepetalactone.
Grayson Wawrzyn, Christine Roche, Patrick J. Westfall, Warren Lau, Savita Ganesan, Fern R. McSorley, Zach Serber
Filed: 29 May 20
Utility
Modular Universal Plasmid Design Strategy for the Assembly and Editing of Multiple Dna Constructs for Multiple Hosts
2 Dec 21
Methods, compositions, and kits for high throughput DNA assembly reactions in vitro.
Brian CHAIKIND, Hendrik Marinus VAN ROSSUM
Filed: 3 Aug 21
Utility
Method for Counterselection In Microorganisms
2 Dec 21
The present disclosure is directed to methods of scarless genomic engineering in microorganisms, such as Bacillus, and provides for new molecular tools and methods which enable scarless genetic editing using at least one counterselectable marker that has been codon optimized for the microorganism.
Tara F. MAHONEY, Amanda Renae REIDER APEL, Paloma RUEDA ROMERO
Filed: 9 Aug 21
Utility
Metagenomic library and natural product discovery platform
30 Nov 21
The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs).
Oliver Liu, Eyal Akiva, Tom Hayon Eyles, Ute Galm, Sangita Ganesh, Stephanie Leanne Brown Hendrix, William W. Hwang, Jeffrey Hoon Kim, Alexander Neckelmann, Samuel Oteng-Pabi, Claus Pelikan, Devin Scannell, Zachariah Serber, Jennifer Shock, Michael Sneddon, Xiao Yang
Filed: 16 Feb 21
Utility
HTP genomic engineering platform for improving fungal strains
23 Nov 21
HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
Filed: 20 Dec 19
Utility
Automated system for HTP genomic engineering
26 Oct 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 18 Dec 20
Utility
HTP genomic engineering platform
26 Oct 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 22 Mar 21
Utility
Multiplexed Deterministic Assembly of Dna Libraries
21 Oct 21
The present disclosure relates to methods of joining three or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro or in vivo.
Erik Jedediah DEAN, Kedar PATEL, Aaron MILLER, Kunal MEHTA, Philip WEYMAN
Filed: 23 Jun 21
Utility
Microbial strain design system and methods for improved large-scale production of engineered nucleotide sequences
19 Oct 21
The generation of a factory order to control production of nucleotide sequences by a gene manufacturing system includes receiving an expression indicating an operation on sequence operands, each representing at least one nucleotide sequence part, evaluating the expression to a sequence specification, wherein the sequence specification comprises a data structure including one or more first-level operations and one or more second-level operations, and generating the factory order based upon execution of the one or more first-level operations and the one or more second-level operations.
Barbara Frewen, Aaron Kimball
Filed: 27 Apr 16
Utility
Optically Transparent Polyimides
14 Oct 21
A polymer film comprising at least two properties selected from (i) a thickness of not greater than 100 μm; (ii) a tensile modulus according to ASTM D882 of at least 5 GPa; (iii) a first optical transparency according to ASTM D1746-15 at 380 nm of less than 50%; (iii) a Yellowing Index according to ASTM E313-15e1 of not greater than 2.5; (iv) a haze as determined according to ASTM D1003-13 of not greater than 1.5%; (v) a pencil hardness of greater than 1H; (vi) a coefficient of moisture expansion (‘CME’) as determined according to ASTM D5229/D5229M-14 of not greater than 50 ppm; (vii) an elongation at break as determined according to ASTM D5034-09 (2017) of at least 10%; or (viii) a folding endurance as determined according to ASTM D2176-16 at a radius of 1 mm of at least 10,000 folds.
Arjan Zoombelt, Steven M. Edgar, Alejandra Alvarez Albarran
Filed: 6 Aug 19
Utility
Applications of CRISPRi in high throughput metabolic engineering
28 Sep 21
Methods, compositions, and kits for high throughput DNA assembly reactions in vitro.
Brian Chaikind, Hendrik M. Van Rossum, Aaron Miller, Paul Perkovich, Shawn Szyjka, Kedar Patel
Filed: 15 Aug 19
Utility
Iterative Genome Editing In Microbes
23 Sep 21
The present invention relates to methods for editing the genome of a microbial host cell in successive rounds of transformation.
Stephen BLASKOWSKI, Sara da Luz Areosa CLETO, Cameron COATES, Aaron MILLER, Sharon NADEMANEE, Melissa NETWAL, Kedar PATEL, Shawn SZYJKA, Philip WEYMAN, Solomon Henry STONEBLOOM, Colin Scott MAXWELL, Elizabeth Lauren MEIER
Filed: 27 May 21
Utility
Systems and Methods for Host Cell Improvement Utilizing Epistatic Effects
16 Sep 21
The present disclosure provides systems and methods for host cell improvement utilizing epistatic effects.
Zachariah SERBER, Erik Jedediah DEAN, Shawn MANCHESTER, Katherine GORA, Michael FLASHMAN, Erin SHELLMAN, Aaron KIMBALL, Shawn SZYJKA, Barbara FREWEN, Thomas TREYNOR, Kenneth S. BRUNO
Filed: 12 May 21
Utility
HTP Genomic Engineering Platform for Improving Fungal Strains
16 Sep 21
A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided.
Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
Filed: 19 Mar 21
Utility
Pooled Genome Editing In Microbes
16 Sep 21
The present invention relates to methods for editing the genome of a microbial host cell in one or more rounds of transformation.
Stephen Blaskowski, Sara da Luz Areosa Cleto, Cameron Coates, Aaron Miller, Sharon Nademanee, Melissa Netwal, Kedar Patel, Shawn Szyjka, Philip Weyman, Solomon Henry Stonebloom, Colin Scott Maxwell, Elizabeth Lauren Meier
Filed: 27 May 21
Utility
Method for Creating a Genomic Library Enriched for Bacillus and Identification of Novel Cry Toxins
9 Sep 21
The disclosure is directed to an approach for discovering novel insecticidal proteins from highly heterogeneous environmental sources.
Jeffrey KIM, Oliver LIU, Jennifer SHOCK, Maritza DUARTE
Filed: 17 May 21
Utility
Insecticidal Protein Discovery Platform and Insecticidal Proteins Discovered Therefrom
9 Sep 21
The disclosure presents a platform for discovering novel insecticidal proteins from highly heterogeneous environmental sources.
William W. HWANG, Jeffrey KIM, Oliver LIU, Jennifer SCHOCK
Filed: 24 May 21
Utility
Method for counterselection in microorganisms
7 Sep 21
The present disclosure is directed to methods of scarless genomic engineering in microorganisms, such as Bacillus, and provides for new molecular tools and methods which enable scarless genetic editing using at least one counterselectable marker that has been codon optimized for the microorganism.
Tara F. Mahoney, Amanda Renae Reider Apel, Paloma Rueda Romero
Filed: 23 Sep 20
Utility
Use of Heterocyclic Amines Containing Primary or Secondary Amines As a Polymer Catalyst or Hardener
26 Aug 21
An epoxy resin composition comprises about 70 wt % to about 95 wt % by weight of the composition of an epoxy component; and a curing component comprising about 5 wt % to about 30 wt % by weight of the composition, wherein the curing component is includes an imidazole; wherein the epoxy component and the curing component react together at a temperature of about 100 C to about 130 C to form a substantially cured reaction product in about 10 minutes or less and the cured product shows high tensile and flexural strength.
Szymon Kosinski, Stephen Lo, Timothy Mauldin, Shilpa Naresh Raja, Nicole G. Ricapito, Adam Safir
Filed: 14 Jun 19
Utility
a HTP Engineering Platform
26 Aug 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah SERBER, Erik Jedediah DEAN, Shawn MANCHESTER, Katherine GORA, Michael FLASHMAN, Erin SHELLMAN, Aaron KIMBALL, Shawn SZYJKA, Barbara FREWEN, Thomas TREYNOR, Kenneth S. BRUNO
Filed: 5 May 21