159 patents
Page 7 of 8
Utility
Identifying Organisms for Production Using Unsupervised Parameter Learning for Outlier Detection
30 Sep 20
Systems, methods and computer-readable media are provided for identifying organisms for production.
Amelia Taylor
Filed: 29 Nov 18
Utility
Automated System for HTP Genomic Engineering
16 Sep 20
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
ZACH SERBER, ERIK JEDEDIAH DEAN, SHAWN MANCHESTER, KATHERINE GORA, MICHAEL FLASHMAN, ERIN SHELLMAN, AARON KIMBALL, SHAWN SZYJKA, BARBARA FREWEN, THOMAS TREYNOR, KENNETH S. BRUNO
Filed: 28 May 20
Utility
Iterative Genome Editing In Microbes
9 Sep 20
The present invention relates to methods for editing the genome of a microbial host cell in successive rounds of transformation.
Stephen BLASKOWSKI, Sara da Luz Areosa CLETO, Cameron Coates, Aaron Miller, Sharon Nademanee, Melissa Netwal, Kedar Patel, Shawn Szyjka, Philip Weyman, Solomon Henry Stonebloom, Colin Scott Maxwell, Elizabeth Lauren Meier
Filed: 19 Mar 20
Utility
Pooled Genome Editing In Microbes
9 Sep 20
The present invention relates to methods for editing the genome of a microbial host cell in one or more rounds of transformation.
Stephen BLASKOWSKI, Sara da Luz Areosa Cleto, Cameron Coates, Aaron Miller, Sharon Nademanee, Melissa Netwal, Kedar Patel, Shawn Szyjka, Philip Weyman, Solomon Henry Stonebloom, Colin Scott Maxwell, Elizabeth Lauren Meier
Filed: 19 Mar 20
Utility
Genomic Engineering of Biosynthetic Pathways Leading to Increased Nadph
19 Aug 20
The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof.
Shawn Manchester, Benjamin Mason, Alexi Goranov
Filed: 17 May 18
Utility
Automated system for HTP genomic engineering
17 Aug 20
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zach Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 26 Nov 19
Utility
Apparatuses and methods for electroporation
3 Aug 20
Disclosed are apparatuses, systems, and methods for performing electroporation.
John Cesarek, Travis Lee, Richard Hansen
Filed: 11 Mar 19
Utility
Optically Transparent Polyimides
29 Jul 20
The present disclosure provides novel polyimides having a high aliphatic monomer-content and improved optical properties and solubility relative to conventional polyimides.
John McNamara, John D. Harvey, Matthew J. Graham, Carolyn Scherger
Filed: 2 Oct 18
Utility
Microbial Strain Improvement by a HTP Genomic Engineering Platform
29 Jul 20
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zach SERBER, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 1 Apr 20
Utility
Promoters from Corynebacterium Glutamicum and Uses Thereof In Regulating Ancillary Gene Expression
29 Jul 20
Provided are native promoters comprising polynucleotides isolated from Corynebacterium glutamicum, and mutant promoters derived therefrom, which may be used to regulate, i.e., either increase or decrease, on-pathway and/or off-pathway gene expression.
Zach Serber, Katherine G. Gora, Shawn P. Manchester, Peter Enyeart, Alexander Shearer
Filed: 6 Jun 18
Utility
Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
29 Jun 20
The present disclosure provides isolated nepetalactone oxidoreductase polypeptides (NORs), nepetalactol synthases (NEPSs), and related polynucleotides, engineered host cells, and cultures, as well as methods for producing NORs and NEPSs, and for using them to produce nepetalactol, nepetalactone, and dihydronepetalactone.
Grayson Wawrzyn, Christine Roche, Patrick J. Westfall, Warren Lau, Savita Ganesan, Fern R. McSorley, Zach Serber
Filed: 6 Aug 19
Utility
Microbial Engineering Methods and Systems for Optimizing Microbe Fitness
3 Jun 20
The present disclosure provides a microbe engineering platform that permits optimization of microbe fitness levels to optimize a microbe's suitability for industrial fermentation.
WILLIAM SERBER, ERIK JEDEDIAH DEAN
Filed: 3 May 18
Utility
Prioritization of Genetic Modifications to Increase Throughput of Phenotypic Optimization
27 May 20
Systems, methods and computer-readable media are provided for determining modifications to apply to genes within at least one microbial strain to improve phenotypic performance.
Anupam Chowdhury, Peter Enyeart, Michael Flashman, Alexander Glennon Shearer, Kurt Thorn
Filed: 4 Jun 18
Utility
Engineered biosynthetic pathways for production of (6E)-8-hydroxygeraniol by fermentation
25 May 20
The present disclosure describes the engineering of microbial cells for fermentative production of (6E)-8-hydroxygeraniol and provides novel engineered microbial cells and cultures, as well as related (6E)-8-hydroxygeraniol production method.
Cara Ann Tracewell, Steven M. Edgar, Stepan Tymoshenko, Alexander Glennon Shearer
Filed: 23 Jun 19
Utility
Automated System for HTP Genomic Engineering
13 May 20
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zach Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 26 Nov 19
Utility
Microbial strain improvement by a HTP genomic engineering platform
11 May 20
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zach Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 30 Jun 19
Utility
Multiplexed Deterministic Assembly of Dna Libraries
29 Apr 20
The present disclosure relates to methods of joining three or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro or in vivo.
Erik Jedediah Dean, Kedar Patel, Aaron Miller, Kunal Mehta, Philip Weyman
Filed: 30 Oct 19
Utility
Methods for Generating a Bacterial Hemoglobin Library and Uses Thereof
22 Apr 20
The present disclosure describes methods for generating microbial strains expressing a heterologous bacterial hemoglobin gene that produce biomolecules of interest.
Shawn Manchester, Alexander Neckelmann
Filed: 19 Dec 19
Utility
Methods for Generating a Glucose Permease Library and Uses Thereof
22 Apr 20
The present disclosure describes methods for generating microbial strains expressing a heterologous bacterial glucose permease gene that produce biomolecules of interest.
Shawn Manchester, Jeffrey Mellin
Filed: 19 Dec 19
Utility
HTP Genomic Engineering Platform for Improving Fungal Strains
22 Apr 20
The present disclosure provides a HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
Filed: 19 Dec 19