49 patents
Utility
Laboratory automation system implementing efficient path for material and lab ware transfers
12 Dec 23
Systems, methods and computer-readable media are provided for determining a sequential ordering of predefined transfers for transferring an object from source points of a source array to destination points of a destination array in a laboratory automation system.
Christopher Bremner
Filed: 26 Jun 20
Utility
Bioreachable chiral dopants for liquid crystal applications
14 Nov 23
The disclosure discusses chiral dopants for liquid-crystalline materials.
Adam Safir, Shilpa Naresh Raja, Arjan Zoombelt, Robert J. Twieg, Pawan Nepal, Ashani Wedige-Fernando, Peter Palffy-Muhoray
Filed: 6 Dec 19
Utility
Compositions and methods for activating silent gene clusters
4 Apr 23
The disclosure provides compositions and methods for producing natural products in microorganisms that are otherwise unexpressed, poorly expressed or poorly transcribed.
Oliver Liu, Jeffrey Hoon Kim
Filed: 17 May 19
Utility
Device-agnostic system for planning and executing high-throughput genomic manufacturing operations
14 Feb 23
High-throughput production of modified microbes is achieved through optimization of directed build graph data structures representing biological workflows.
Kiyan Ahmadizadeh, Tessa Alexanian, Barbara Frewen, Prasad Ganesan, Aaron Kimball, William J. Mania, Zachary Palchick, Erin Rhode, Dylan Webster
Filed: 25 Oct 18
Utility
Identifying organisms for production using unsupervised parameter learning for outlier detection
7 Feb 23
Systems, methods and computer-readable media are provided for identifying organisms for production.
Amelia Taylor
Filed: 30 Nov 18
Utility
Genetic perturbation of the RNA degradosome protein complex
10 Jan 23
The present disclosure provides novel bacterial strains with altered expression or start codon modification of one or more RNA degradation/processing genes.
Shawn Manchester
Filed: 27 Jun 17
Utility
Genomic engineering of biosynthetic pathways leading to increased NADPH
6 Dec 22
The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof.
Shawn Manchester, Benjamin Mason, Alexi Goranov
Filed: 18 May 18
Utility
Metagenomic library and natural product discovery platform
8 Nov 22
The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs).
Oliver Liu, Eyal Akiva, Tom Hayon Eyles, Ute Galm, Sangita Ganesh, Stephanie Leanne Brown Hendrix, William W. Hwang, Jeffrey Hoon Kim, Alexander Neckelmann, Samuel Oteng-Pabi, Claus Pelikan, Devin Scannell, Zachariah Serber, Jennifer Shock, Michael W. Sneddon, Xiao Yang
Filed: 21 Sep 21
Utility
Systems and methods for high-throughput automated strain generation for non-sporulating fungi
25 Oct 22
Embodiments disclosed include systems and methods to generate and/or improve non-sporulating filamentous fungal cells using high-throughput techniques.
Benjamin Knox, Nasim Mansoori Zangir, Ryan Evan Martinez, Hassan Abdulla
Filed: 28 Jul 21
Utility
Apparatuses and methods for electroporation
11 Oct 22
Disclosed are apparatuses, systems, and methods for performing electroporation.
John Cesarek, Travis Lee, Richard Hansen
Filed: 26 Jun 20
Utility
Metal-organic framework materials
27 Sep 22
The present disclosure provides novel metal-organic framework materials (MOFs) useful, for example, for gas adsorption, storage, and/or separation.
Adam Safir, Adam J. Matzger, Shantel Leithead, Jialiu Ma, Gregory W. Peterson, John McNamara
Filed: 17 Jul 18
Utility
HTP genomic engineering platform
7 Jun 22
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 7 May 21
Utility
Systems and methods for host cell improvement utilizing epistatic effects
26 Apr 22
The present disclosure provides systems and methods for host cell improvement utilizing epistatic effects.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 12 May 21
Utility
Promoters from
5 Apr 22
Provided are native promoters comprising polynucleotides isolated from Corynebacterium glutamicum, and mutant promoters derived therefrom, which may be used to regulate, i.e., either increase or decrease, gene expression.
Zachariah Serber, Katherine G. Gora, Shawn P. Manchester
Filed: 7 Dec 16
Utility
Iterative genome editing in microbes
22 Mar 22
The present invention relates to methods for editing the genome of a microbial host cell in successive rounds of transformation.
Stephen Blaskowski, Sara da Luz Areosa Cleto, Cameron Coates, Aaron Miller, Sharon Nademanee, Melissa Netwal, Kedar Patel, Shawn Szyjka, Philip Weyman, Solomon Henry Stonebloom, Colin Scott Maxwell, Elizabeth Lauren Meier
Filed: 27 May 21
Utility
HTP genomic engineering platform for improving fungal strains
8 Feb 22
A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided.
Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
Filed: 19 Mar 21
Utility
Microbial engineering methods and systems for optimizing microbe fitness
18 Jan 22
The present disclosure provides a microbe engineering platform that permits optimization of microbe fitness levels to optimize a microbe's suitability for industrial fermentation.
William Serber, Erik Jedediah Dean
Filed: 4 May 18
Utility
HTP genomic engineering platform
28 Dec 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 5 May 21
Utility
Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
7 Dec 21
The present disclosure provides isolated nepetalactone oxidoreductase polypeptides (NORs), nepetalactol synthases (NEPSs), and related polynucleotides, engineered host cells, and cultures, as well as methods for producing NORs and NEPSs, and for using them to produce nepetalactol, nepetalactone, and dihydronepetalactone.
Grayson Wawrzyn, Christine Roche, Patrick J. Westfall, Warren Lau, Savita Ganesan, Fern R. McSorley, Zach Serber
Filed: 29 May 20
Utility
Metagenomic library and natural product discovery platform
30 Nov 21
The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs).
Oliver Liu, Eyal Akiva, Tom Hayon Eyles, Ute Galm, Sangita Ganesh, Stephanie Leanne Brown Hendrix, William W. Hwang, Jeffrey Hoon Kim, Alexander Neckelmann, Samuel Oteng-Pabi, Claus Pelikan, Devin Scannell, Zachariah Serber, Jennifer Shock, Michael Sneddon, Xiao Yang
Filed: 16 Feb 21