49 patents
Page 2 of 3
Utility
HTP genomic engineering platform for improving fungal strains
23 Nov 21
HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
Filed: 20 Dec 19
Utility
Automated system for HTP genomic engineering
26 Oct 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 18 Dec 20
Utility
HTP genomic engineering platform
26 Oct 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 22 Mar 21
Utility
Microbial strain design system and methods for improved large-scale production of engineered nucleotide sequences
19 Oct 21
The generation of a factory order to control production of nucleotide sequences by a gene manufacturing system includes receiving an expression indicating an operation on sequence operands, each representing at least one nucleotide sequence part, evaluating the expression to a sequence specification, wherein the sequence specification comprises a data structure including one or more first-level operations and one or more second-level operations, and generating the factory order based upon execution of the one or more first-level operations and the one or more second-level operations.
Barbara Frewen, Aaron Kimball
Filed: 27 Apr 16
Utility
Applications of CRISPRi in high throughput metabolic engineering
28 Sep 21
Methods, compositions, and kits for high throughput DNA assembly reactions in vitro.
Brian Chaikind, Hendrik M. Van Rossum, Aaron Miller, Paul Perkovich, Shawn Szyjka, Kedar Patel
Filed: 15 Aug 19
Utility
Method for counterselection in microorganisms
7 Sep 21
The present disclosure is directed to methods of scarless genomic engineering in microorganisms, such as Bacillus, and provides for new molecular tools and methods which enable scarless genetic editing using at least one counterselectable marker that has been codon optimized for the microorganism.
Tara F. Mahoney, Amanda Renae Reider Apel, Paloma Rueda Romero
Filed: 23 Sep 20
Utility
Liquid based selection and cell isolation
24 Aug 21
Aspects of this disclosure relate to liquid-based workflows for strain engineering.
Sean Poust, Vytas SunSpiral, William Serber, Matthew Jonathan Myers, Sara da Luz Areosa Cleto, Philip Weyman
Filed: 2 Jul 19
Utility
Modular universal plasmid design strategy for the assembly and editing of multiple DNA constructs for multiple hosts
24 Aug 21
Methods, compositions, and kits for high throughput DNA assembly reactions in vitro.
Brian Chaikind, Hendrik Marinus van Rossum
Filed: 8 Aug 19
Utility
Systems and methods for host cell improvement utilizing epistatic effects
10 Aug 21
The present disclosure provides systems and methods for host cell improvement utilizing epistatic effects.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 28 Oct 19
Utility
Multiplexed deterministic assembly of DNA libraries
20 Jul 21
The present disclosure relates to methods of joining three or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro or in vivo.
Erik Jedediah Dean, Kedar Patel, Aaron Miller, Kunal Mehta, Philip Weyman
Filed: 31 Oct 19
Utility
Iterative genome editing in microbes
6 Jul 21
The present invention relates to methods for editing the genome of a microbial host cell in successive rounds of transformation.
Stephen Blaskowski, Sara da Luz Areosa Cleto, Cameron Coates, Aaron Miller, Sharon Nademanee, Melissa Netwal, Kedar Patel, Shawn Szyjka, Philip Weyman, Solomon Henry Stonebloom, Colin Scott Maxwell, Elizabeth Lauren Meier
Filed: 20 Mar 20
Utility
Pooled genome editing in microbes
6 Jul 21
The present invention relates to methods for editing the genome of a microbial host cell in one or more rounds of transformation.
Stephen Blaskowski, Sara da Luz Areosa Cleto, Cameron Coates, Aaron Miller, Sharon Nademanee, Melissa Netwal, Kedar Patel, Shawn Szyjka, Philip Weyman, Solomon Henry Stonebloom, Colin Scott Maxwell, Elizabeth Lauren Meier
Filed: 20 Mar 20
Utility
Insecticidal protein discovery platform and insecticidal proteins discovered therefrom
29 Jun 21
The disclosure presents a platform for discovering novel insecticidal proteins from highly heterogeneous environmental sources.
William W. Hwang, Jeffrey Kim, Oliver Liu, Jennifer Shock
Filed: 1 Sep 20
Utility
Manipulation of genes involved in signal transduction to control fungal morphology during fermentation and production
8 Jun 21
The present disclosure provides a microbial genomic engineering method and system for transforming, screening, and selecting filamentous fungal cells that have altered morphology and/or growth under specific growth conditions.
Kenneth S. Bruno, Sachin Jain, Brandon Pfannenstiel, Edyta Szewczyk
Filed: 6 Jun 19
Utility
Engineered biosynthetic pathways for production of tyramine by fermentation
8 Jun 21
The present disclosure describes the engineering of microbial cells for fermentative production of tyramine and provides novel engineered microbial cells and cultures, as well as related tyramine production methods.
Michael Shareef Siddiqui, Stefan de Kok, Alexander Glennon Shearer, Franklin Lu, Cara Ann Tracewell, Steven M. Edgar
Filed: 26 Jun 19
Utility
Method for creating a genomic library enriched for
18 May 21
The disclosure is directed to an approach for discovering novel insecticidal proteins from highly heterogeneous environmental sources.
Jeffrey Kim, Oliver Liu, Jennifer Shock, Maritza Duarte
Filed: 20 Aug 20
Utility
HTP platform for the genetic engineering of Chinese hamster ovary cells
27 Apr 21
Presented herein is a high-throughput (HTP) genomic engineering platform for improving the production of therapeutic proteins in Chinese hamster ovary (CHO) cells.
Kate Caves, Amarjeet Singh
Filed: 20 Jul 20
Utility
HTP genomic engineering platform
6 Apr 21
The present disclosure provides machine learning techniques for computationally predicting the phenotypic performance of combinations of genetic variations and for designing new improved host cells.
Zach Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 15 Oct 20
Utility
HTP genomic engineering platform for improving fungal strains
23 Mar 21
A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided.
Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
Filed: 11 Oct 19
Utility
Automated system for HTP genomic engineering
4 Jan 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zach Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 28 May 20