13 patents
Utility
Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers
18 Jul 23
A method of treating a disorder in a subject.
Louis Anthony Tartaglia, Bart Henderson, Leonardus H. T. Van Der Ploeg
Filed: 13 Nov 20
Utility
Method of Treating MELANOCORTIN-4 Receptor Pathway-associated Disorders
21 Jul 22
The disclosure is related to a method of treating a disorder, such as obesity or a condition associated with obesity, such as hyperphagia, in a subject using a melanocortin-4 receptor (MC4R) agonist.
Leonardus H.T. Van Der Ploeg, Barton T. Henderson, Shubh Sharma
Filed: 4 Apr 22
Utility
Pharmaceutical Compositions
26 May 22
The present invention relates to an ionic complex comprising a cationic polypeptide and an anionic excipient selected from: a PEG-carboxylic acid; a fatty acid having 10 or more carbon atoms; an anionic phospholipid; and a combination thereof.
Shubh Sharma, Leonardus H.T. Van Der Ploeg, Bart T. Henderson
Filed: 13 Aug 21
Utility
Pharmaceutical compositions
28 Sep 21
The present invention relates to an ionic complex comprising a cationic polypeptide and an anionic excipient selected from: a PEG-carboxylic acid; a fatty acid having 10 or more carbon atoms; an anionic phospholipid; and a combination thereof.
Shubh Sharma, Leonardus H. T. Van Der Ploeg, Bart Henderson
Filed: 14 Mar 14
Utility
Sustained Release Peptide Formulations
10 Jun 21
This disclosure provides, at least in part, a pharmaceutical product comprising: setmelanotide (also known as RM493); setmelanotide as sole active pharmaceutical ingredient formulated for injection; setmelanotide as the sole active ingredient; setmelanotide as the active pharmaceutical ingredient; setmelanotide as the active pharmaceutical ingredient for injection; or another pharmaceutical composition that has its primary mechanism of action at the MC4 receptor as an agonist (referred to herein as an MC4RAp), e.g., a lipid excipient, and/or a pharmaceutically acceptable carrier.
Michael John Dey, Jaya Gautam, Barton T. Henderson, Markus Johnsson, Stina Lindman
Filed: 15 Nov 18
Utility
Compositions for Treating Kidney Disease
10 Jun 21
The disclosure is related to a method of treating chronic kidney disease in a subject with a melanocortin-4 receptor (MC4R) agonist, e.g., a compound of any one of Formulas (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (X), or (XI), or a pharmaceutically acceptable salt thereof (e.g., as described herein).
Leonardus H.T. Van Der Ploeg, Alastair Garfield, Vincent Marion
Filed: 5 Apr 19
Utility
Method of Treating MELANOCORTIN-4 Receptor Pathway-associated Disorders
10 Jun 21
The disclosure is related to a method of treating a disorder, such as Prader Willi Syndrome (PWS), obesity or hyperphagia, in a subject using a melanocortin-4 receptor (MC4R) agonist.
Leonardus H.T. Van Der Ploeg, Bart Henderson, Peter Kuhnen
Filed: 9 Feb 21
Utility
Method of treating melanocortin-4 receptor pathway-associated disorders
30 Mar 21
The disclosure is related to a method of treating a disorder, such as Prader Willi Syndrome (PWS), obesity or hyperphagia, in a subject using a melanocortin-4 receptor (MC4R) agonist.
Leonardus H. T. Van Der Ploeg, Bart Henderson, Peter Kuhnen
Filed: 29 Sep 16
Utility
Method of treating melanocortin-4 receptor-associated disorders in heterozygous carriers
23 Mar 21
A method of treating a disorder in a subject.
Louis Anthony Tartaglia, Bart Henderson, Leonardus H. T. Van Der Ploeg
Filed: 15 Apr 19
Utility
Method of Treating MELANOCORTIN-4 Receptor-associated Disorders In Heterozygous Carriers
4 Mar 21
A method of treating a disorder in a subject.
Louis Anthony Tartaglia, Bart Henderson, Leonardus H.T. Van Der Ploeg
Filed: 13 Nov 20
Utility
Peptide Compositions
11 Feb 21
Shubh Sharma, Leonardus H.T. Van Der Ploeg, Bart Henderson
Filed: 26 Oct 20
Utility
Peptide compositions
7 Dec 20
Shubh Sharma, Leonardus H. T. Van Der Ploeg, Bart Henderson
Filed: 10 Dec 18
Utility
Method of Treating MELANOCORTIN-4 Receptor-associated Disorders In Heterozygous Carriers
15 Jan 20
A method of treating a disorder in a subject.
Louis Anthony Tartaglia, Bart Henderson, Leonardus H.T. Van Der Ploeg
Filed: 14 Apr 19
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