45 patents
Utility
Compositions and Methods for Reducing MHC Class II in a Cell
18 Jan 24
Compositions and methods for reducing MHC class II protein expression in a cell comprising genetically modifying CIITA for use e.g., in adoptive cell transfer therapies.
Srijani Sridhar, Yong Zhang, William Frederick Harrington, Surbhi Goel
Filed: 9 Jun 23
Utility
Compositions and Methods for Kallikrein (KLKB1) Gene Editing
18 Jan 24
Compositions and methods for editing, e.g., introducing double-stranded breaks, within the KLKB1 gene are provided.
Shobu Odate, Jessica Lynn Seitzer
Filed: 31 Jul 23
Utility
Compositions and Methods for the Treatment of Hemoglobinopathies
4 Jan 24
The present invention is directed to genome editing systems, reagents and methods for the treatment of hemoglobinopathies.
Anthony Edward BOITANO, Michael COOKE, Lloyd B. KLICKSTEIN, Reynald LESCARBEAU, Craig Stephen MICKANIN, Kabungo MULUMBA, Seshidhar Reddy POLICE, Jennifer SNEAD, Susan C. STEVENSON, Morag STEWART, Yi YANG
Filed: 13 Oct 22
Utility
Polynucleotides, Compositions, and Methods for Genome Editing Involving Deamination
4 Jan 24
Polynucleotides, polypeptides, compositions, and methods for genome editing using deamination are provided.
Christian Dombrowski, William Frederick Harrington, Ruan Oliveira
Filed: 9 Jun 23
Utility
Natural Killer Cell Receptor 2B4 Compositions and Methods for Immunotherapy
30 Nov 23
Compositions and methods for editing, e.g., altering a DNA sequence, within a 2B4 gene are provided.
Danielle Ryan Cook
Filed: 7 Aug 23
Utility
Lymphocyte Activation Gene 3 (LAG3) Compositions and Methods for Immunotherapy
30 Nov 23
Compositions and methods for editing, e.g., altering a DNA sequence, within a LAG3 gene are provided.
Danielle Ryan Cook
Filed: 7 Aug 23
Utility
T-Cell Immunoglobulin and Mucin Domain 3 (TIM3) Compositions and Methods for Immunotherapy
23 Nov 23
Compositions and methods for editing, e.g., altering a DNA sequence, within a TIM3 gene are provided.
Danielle Ryan Cook
Filed: 7 Aug 23
Utility
Methods and Compositions for Ocular Cell Therapy
2 Nov 23
The present invention provides ocular cells, genetically modified by a CRISPR system targeting the expression of B2M for ocular cell therapy.
Frada BERENSHTEYN, Bo HAN, Xueshi HAO, Jessica HEYDER, Timothy Z. HOFFMAN, Qihui JIN, Arnaud LACOSTE, Jun LIU, Yahu LIU, Tingting MO, Bradley Andrew MURRAY, Daniel Joseph O’CONNELL, Jianfeng PAN, Yun Feng XIE, Shanshan YAN, Yefen ZOU
Filed: 26 Apr 21
Utility
Compositions and Methods for Kallikrein (KLKB1) Gene Editing
21 Sep 23
Compositions and methods for editing, e.g., introducing double-stranded breaks, within the KLKB1 gene are provided.
Shobu Odate, Jessica Lynn Seitzer
Filed: 5 Aug 22
Utility
Modified Guide RNAs
14 Sep 23
This disclosure relates to modified single and dual guide RNAs having improved in vitro and in vivo activity in gene editing methods.
Amy Madison Rhoden Smith, David V. Morrissey, Walter Strapps
Filed: 1 Sep 22
Utility
Stabilized Nucleic Acids Encoding Messenger Ribonucleic Acid (mRNA)
31 Aug 23
This disclosure relates to the field of poly-adenylated (poly-A) tails.
Christian Dombrowski
Filed: 1 May 23
Utility
Compositions and Methods for TTR Gene Editing and Treating ATTR Amyloidosis
17 Aug 23
Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided.
Arti Mahendra Prakash Kanjolia, Shobu Odate, Jessica Lynn Seitzer, Reynald Michael Lescarbeau, Walter Strapps
Filed: 9 Dec 22
Utility
Compositions and Methods for Treating Alpha-1 Antitrypsin Deficiency
6 Jul 23
Compositions and methods for introducing double-stranded breaks within the SERPINA1 gene are provided.
Shobu Odate, Walter Strapps, Reynald Michael Lescarbeau
Filed: 9 Dec 22
Utility
Lipid Nanoparticle Formulations for Crispr/cas Components
29 Jun 23
The invention provides lipid nanoparticle-based compositions and methods useful for delivery of CRISPR/Cas gene editing components.
David V. Morrissey, Mihir Chandrakant Patel, Jonathan D. Finn, Amy Madison Rhoden Smith, Lucinda J. Shaw, Christian Dombrowksi, Ruchi Rudraprasad Shah
Filed: 29 Aug 22
Utility
Formulations
4 May 23
The invention provides lipid nanoparticle-based compositions with improved properties for delivery of biologically active agents, engineered cells, and methods for delivery of the agents.
Kristy M. Wood, Noah P. Gardner, Ruchi R. Shah, Stephen S. Scully, Ramsey Majzoub
Filed: 28 Sep 18
Utility
Compositions and Methods for TTR Gene Editing and Treating ATTR Amyloidosis
20 Apr 23
Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided.
Arti Mahendra Prakash Kanjolia, Shobu Odate, Jessica Lynn Seitzer, Reynald Michael Lescarbeau, Walter Strapps
Filed: 9 Dec 22
Utility
Compositions and Methods for the Treatment of Hemoglobinopathies
20 Apr 23
The present invention is directed to genome editing systems, reagents and methods for the treatment of hemoglobinopathies.
Craig Stephen MICKANIN, Christian SCHMEDT, Jennifer SNEAD, Susan C. Stevenson, Yi YANG
Filed: 24 Jun 22
Utility
Methods and Compositions for Directed Genome Editing
9 Mar 23
Provided herein are compositions and methods for increasing editing efficiency of a target nucleic acid.
Schaked Omer HALPERIN
Filed: 3 May 22
Utility
Compositions and Methods Comprising a TTR Guide RNA and a Polynucleotide Encoding an RNA-Guided DNA Binding Agent
9 Feb 23
Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided.
Yong Chang, Seth C. Alexander, Kristy M. Wood, Arti Mahendra Prakash Kanjolia, Shobu Odate, Jessica Lynn Seitzer, Reynald Michael Lescarbeau, Walter Strapps
Filed: 27 Sep 21
Utility
Compositions and Methods for TTR Gene Editing and Treating ATTR Amyloidosis Comprising a Corticosteroid or Use Thereof
2 Feb 23
Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene in combination with administration of a corticosteroid are provided.
Yong CHANG, Seth C. ALEXANDER, Kristy M. WOOD, Arti Mahendra Prakash KANJOLIA, Shobu ODATE, Jessica Lynn SEITZER, Reynald Michael LESCARBEAU, Walter STRAPPS
Filed: 27 Sep 21