9 patents
Utility
Tau-protein targeting PROTACs and associated methods of use
4 Oct 22
The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein.
Andrew P. Crew, Michael Berlin, Hanqing Dong, Alexey Ishchenko
Filed: 1 Nov 17
Utility
Compounds and methods for the targeted degradation of androgen receptor
7 Jun 22
The present invention relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor.
Meizhong Jin, Andrew P. Crew, Hanqing Dong, Jing Wang, Xin Chen, Yimin Qian
Filed: 20 Jan 16
Utility
Compounds and methods for the targeted degradation of bromodomain-containing proteins
14 Sep 20
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention.
Yimin Qian, Hanqing Dong, Jing Wang, Michael Berlin, Andrew P. Crew, Craig M. Crews
Filed: 4 Aug 16
Utility
Compounds and methods for the enhanced degradation of targeted proteins
3 Aug 20
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention.
Andrew P. Crew, Craig M. Crews, Xin Chen, Hanqing Dong, Caterina Ferraro, Yimin Qian, Kam Siu, Jing Wang, Meizhong Jin, Michael Berlin, Kurt Zimmermann, Lawrence Snyder
Filed: 17 Mar 16
Utility
Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
27 Jul 20
The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein).
Andrew P. Crew, Keith R. Hornberger, Jing Wang, Hanqing Dong, Yimin Qian, Craig M. Crews, Saul Jaime-Figueroa
Filed: 21 Dec 17
Utility
Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders
11 May 20
The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein).
Andrew P. Crew, Yimin Qian, Hanqing Dong, Jing Wang
Filed: 30 Nov 17
Utility
Modulators of estrogen receptor proteolysis and associated methods of use
30 Mar 20
The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein).
Andrew P. Crew, Keith R. Hornberger, Hanqing Dong, Jing Wang, Yimin Qian, Craig M. Crews
Filed: 25 Jan 18
Utility
Compounds and Methods for the Targeted Degradation of Androgen Receptor
25 Mar 20
The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor.
Andrew P. CREW, Keith R. HORNBERGER, Lawrence B. SNYDER, Kurt ZIMMERMANN, Jing WANG, Michael BERLIN, Craig M. CREWS, Hanqing DONG
Filed: 19 Sep 19
Utility
Compounds and methods for the targeted degradation of androgen receptor
9 Mar 20
The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor.
Andrew P. Crew, Lawrence B. Snyder, Jing Wang
Filed: 10 Oct 17
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