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Gritstone Bio (GRTS)

Utility
Neoantigen Identification Using Hotspots
12 May 22
A method for identifying neoantigens that are likely to be presented on a surface of tumor cells of a subject.
Brendan Bulik-Sullivan, Thomas Francis Boucher, Roman Yelensky
Filed: 21 Jan 22
Utility
Alphavirus Neoantigen Vectors and Interferon Inhibitors
28 Apr 22
Disclosed herein are vectors that include alphavirus-based expression platforms.
Karin Jooss, Amy Rachel Rappaport, Leonid Gitlin
Filed: 7 Nov 19
Utility
Modified Adenoviruses
24 Mar 22
Disclosed herein are compositions that include modified adenoviruses.
Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
Filed: 30 Nov 21
Utility
Neoantigen identification using hotspots
1 Mar 22
A method for identifying neoantigens that are likely to be presented on a surface of tumor cells of a subject.
Brendan Bulik-Sullivan, Thomas Francis Boucher, Roman Yelensky
Filed: 3 May 19
Utility
Neoantigen identification, manufacture, and use
23 Nov 21
Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations.
Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
Filed: 23 Nov 20
Utility
Neoantigen Identification, Manufacture, and Use
22 Apr 21
Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations.
Thomas Boucher, Brendan Bulik-Sullivan, Jennifer Busby, Roman Yelensky
Filed: 19 Apr 18
Utility
Neoantigen Identification, Manufacture, and Use
1 Apr 21
Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations.
Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
Filed: 23 Nov 20
Utility
Antigen-Binding Proteins Targeting Shared Antigens
4 Mar 21
Provided herein are HLA-PEPTIDE targets and antigen binding proteins that bind HLA-PEPTIDE targets.
Karin Jooss, Wade Blair, Brendan Bulik-Sullivan, Michele Anne Busby, Jennifer Busby, Joshua Michael Francis, Gijsbert Marnix Grotenbreg, Mojca Skoberne, Roman Yelensky
Filed: 28 Dec 18
Utility
Reducing Junction Epitope Presentation for Neoantigens
14 Jan 21
Given a set of therapeutic epitopes, a cassette sequence is designed to reduce the likelihood that junction epitopes are presented in the patient.
Brendan Bulik-Sullivan, Thomas Francis Boucher, Roman Yelensky, Jennifer Busby
Filed: 21 Nov 18
Utility
Neoantigen Identification with Pan-Allele Models
30 Dec 20
A method for identifying neoantigens that are likely to be presented by MHC alleles on a surface of tumor cells of a subject.
Thomas Francis Boucher, Brendan Bulik-Sullivan, Jennifer Busby, Mojca Skoberne, Roman Yelensky
Filed: 26 Feb 19
Utility
Neoantigen identification, manufacture, and use
23 Nov 20
Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations.
Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
Filed: 5 Jun 18
Utility
Neoantigen identification, manufacture, and use
23 Nov 20
Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations.
Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
Filed: 18 Jul 18
Utility
Neoantigen Identification for T-Cell Therapy
18 Nov 20
A method for identifying T-cells that are antigen-specific for at least one neoantigen that is likely to be presented on surfaces of tumor cells of a subject.
Roman Yelensky, Brendan Bulik-Sullivan, Jennifer Busby, Matthew Joseph Davis, Lauren Elizabeth Young, Joshua Michael Francis, Christine Palmer, Mojca Skoberne
Filed: 4 Sep 18
Utility
Alphavirus Neoantigen Vectors
24 Jun 20
Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject.
Wade BLAIR, Karin JOOSS, Amy Rachel RAPPAPORT, Ciaran Daniel SCALLAN, Leonid GITLIN
Filed: 7 May 18
Utility
Neoantigen Identification, Manufacture, and Use
1 Apr 20
Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations.
Brendan Bulik-Sullivan, Roman Yelensky, Jennifer Busby, Adnan Derti
Filed: 7 Jun 18
Utility
Viral Delivery of Neoantigens
8 Jan 20
Disclosed herein are chimpanzee adenoviral vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject.
Wade Blair, Brendan Bulik-Sullivan, Jennifer Busby, Adnan Derti, Leonid Gitlin, Gijsbert Grotenbreg, Karin Jooss, Ciaran Daniel Scallan, Roman Yelensky
Filed: 21 Nov 17
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