Loading...
Docoh

Codiak Biosciences (CDAK)

Utility
Treatment of Cancer Metastasis by Targeting Exosome Proteins
12 May 22
The present disclosure provides a therapeutic method of treating cancer metastasis by inducing clearance of EVs using a binding agent specific to an EV protein.
Kevin P. DOOLEY, Douglas E. WILLIAMS
Filed: 4 Feb 20
Utility
Engineered Extracellular Vesicles and Uses Thereof
20 Jan 22
The present disclosure relates to therapeutic exosomes enriched in proteins that are present in the luminal surface of exosomes.
Kevin P. DOOLEY, Rane A. HARRISON, Ke XU, Damian J. HOUDE, Sonya HAUPT, John D. KULMAN, Douglas E. WILLIAMS, Russell E. MCCONNELL, Madeleine YOUNISS
Filed: 22 May 19
Utility
Methods to Improve Potency of Electroporation
23 Dec 21
Compositions and methods for reducing nucleotide oxidation during electroporation, specifically the use of free radical scavengers to reduce electroporation-induced oxidation, are described.
Raymond W. BOURDEAU, Delai CHEN, Rane HARRISON, Kathryn E. GOLDEN, Douglas E. WILLIAMS, Sergey DZEKUNOV, Madhusudan PESHWA
Filed: 23 Oct 19
Utility
Extracellular Vesicles Comprising Sting-agonist
21 Oct 21
Provided herein are compositions comprising EV, e.g., exosome, encapsulated STING agonists and methods of producing the compositions described.
Su Chul JANG, Chang Ling SIA, Nuruddeen D. LEWIS, Rane A. HARRISON, Raymond J. MONIZ, Sriram SATHYANARAYANAN, Douglas E. WILLIAMS, Kyriakos ECONOMIDES
Filed: 22 Mar 19
Utility
Methods of Suppressing Delivery of Exosomes to Liver and Spleen
23 Sep 21
The instant application describes improved methods and compositions for the systemic delivery of therapeutic exosomes to a subject in need thereof.
Douglas E. Williams, John D. Kulman
Filed: 21 Aug 17
Utility
Methods of Measuring Extracellular Vesicles and Nanoparticles In Complex Matrices by Light Scattering
26 Aug 21
Described herein are novel rapid and reliable methods of detection of extracellular vesicles and quantifying extracellular vesicle concentrations and absolute number from various sources, including raw cell harvest.
Young Jun CHOI, Damian J. HOUDE, Delai CHEN, Douglas E. WILLIAMS
Filed: 21 Jun 19
Utility
Loading of Extracellular Vesicles Through Imparting of Mechanical Shear
1 Apr 21
Methods of loading extracellular vesicles with payload molecules via homogenization are disclosed herein.
Aaron R. NOYES, Michael P. MERCALDI, Kathryn E. GOLDEN, Raymond W. BOURDEAU, Michael F. DOHERTY, Konstantin KONSTANTINOV, Douglas E. WILLIAMS
Filed: 8 Sep 20
Utility
Exosome Transfer of Nucleic Acids to Cells
6 Jan 21
Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.
Jan LÖTVALL, Hadi VALADI
Filed: 17 Jun 20
Utility
Exosomes for Immuno-oncology and Anti-inflammatory Therapy
30 Dec 20
Disclosed herein are extracellular vesicles comprising an immunomodulating component.
Nuruddeen D. LEWIS, Yu ZHOU, Sriram SATHYANARAYANAN, John KULMAN, Douglas E. WILLIAMS, Leonid A. GAYDUKOV, Ke XU, Shelly MARTIN
Filed: 5 Jul 20
Utility
Methods and Compositions for Macrophage Polarization
30 Dec 20
Disclosed herein are compositions and methods comprising extracellular vesicles comprising nucleic acid that target genes, leading to macrophage polarization of tumor associated macrophages.
Sriram SATHYANARAYANAN, Douglas E. WILLIAMS, Dalia BURZYN, Adam Thomas BOUTIN, Sushrut KAMERKAR
Filed: 11 Feb 19
Utility
Compositions of Engineered Exosomes and Methods of Loading Luminal Exosomes Pay-loads
4 Nov 20
The present invention relates to methods of preparing a therapeutic exosome using proteins newly identified to be enriched in the lumen of exosomes.
Russell E. MCCONNELL, Kevin P. DOOLEY, Rane A. HARRISON, Ke XU, Damian J. HOUDE, Sonya HAUPT, John D. KULMAN, Douglas E. WILLIAMS, Madeleine YOUNISS
Filed: 15 Nov 18
Utility
Exosomes for immuno-oncology and anti-inflammatory therapy
27 Jul 20
Disclosed herein are extracellular vesicles comprising an immunomodulating component.
Nuruddeen D. Lewis, Yu Zhou, Sriram Sathyanarayanan, John D. Kulman, Douglas E. Williams, Leonid A. Gaydukov, Ke Xu, Shelly Martin
Filed: 27 Dec 18
Utility
Preparation of Therapeutic Exosomes Using Membrane Proteins
15 Jul 20
The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes.
Kevin P. DOOLEY, Rane A. HARRISON, Russell E. MCCONNELL, Ke XU, Damian J. HOUDE, Nikki ROSS, Sonya HAUPT, John D. KULMAN, Douglas E. WILLIAMS
Filed: 19 Dec 19
Utility
Exosome transfer of nucleic acids to cells
29 Jun 20
Methods for introducing nucleic acids to cells via exosomes for use in gene modulation and therapy, such as for gene silencing and to introduce genetic material into cells to compensate for abnormal genes or to induce or repress a process in the recipient cell.
Jan Lötvall, Hadi Valadi
Filed: 26 Nov 18
Utility
Nanovesicles Produced from Mesenchymal Stromal Cells for Anti-inflammatory Applications
27 May 20
The invention relates to methods for production of extracellular vesicle-mimetic nanovesicles from mesenchymal stem cells to treat or prevent inflammatory related conditions or diseases.
Kyong-su PARK, Elga Bernardo BANDEIRA DE MELO, Jan LOTVALL
Filed: 16 Jul 18
Utility
Therapeutic Membrane Vesicles
20 May 20
The present invention relates to a method for producing membrane vesicles from extracellular vesicles or organelles and therapeutic membrane vesicles produced by such method.
Jan Lõtvall, Su Chul Jang
Filed: 14 Mar 17
Utility
Delivery of Therapeutic Agent
26 Feb 20
A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method comprises a) introducing a DNA sequence encoding an oligonucleotide capable of inhibiting a human oncogenic or proto-oncogenic transcription factor, into a mammalian cell; b) allowing the cell to express said inhibitor oligonucleotide; and c) obtaining nanovesicles containing said inhibitor oligonucleotide from said cell.
Jan LÖTVALL, Jonas Andrej NILSSON
Filed: 1 Aug 19
Utility
Preparation of therapeutic exosomes using membrane proteins
17 Feb 20
The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes.
Kevin P. Dooley, Rane A. Harrison, Russell E. McConnell, Ke Xu, Damian J. Houde, Nikki Ross, Sonya Haupt, John D. Kulman, Douglas E. Williams
Filed: 20 Dec 18
Utility
Methods of Measuring Exosomes Using Intrinsic Fluorescence
22 Jan 20
Described herein are novel rapid and reliable methods of detection of extracellular vesicles and quantifying extracellular vesicle concentrations and absolute number from various sources, including raw cell harvest.
Damian J. HOUDE, Young Jun CHOI, John D. KULMAN, Douglas E. WILLIAMS
Filed: 13 Dec 17
  • 1
Patents are sorted by USPTO publication date, most recent first