11 patents
Utility
Superpiggybac transposase compositions
31 Oct 23
The disclosure provides a method of producing modified stem memory T cells (e.g.
Eric M. Ostertag, Devon Shedlock
Filed: 29 Oct 19
Utility
Compositions and methods for selective elimination and replacement of hematopoietic stem cells
5 Sep 23
Disclosed are methods of eliminating at least on target cell in a subject, comprising administering to the subject an effective amount of a composition comprising a plurality of immune cells, wherein each immune cell of the plurality expresses one or more chimeric ligand receptor(s) (CLR(s)) that each specifically bind to a target ligand on the at least one target cell, wherein specifically binding of the one or more CLR(s) to the target activates the immune cell, and wherein the activated immune cell induces death of the target cell.
Eric M. Ostertag, Devon Shedlock, Julian David Down
Filed: 13 Mar 18
Utility
Inducible caspases and methods for use
8 Aug 23
The disclosure provides inducible caspase polypeptides, compositions comprising inducible caspase polypeptides and sequences encoding the same, cells modified to express the polypeptides and compositions of the disclosure, as well as methods of making and methods of using same for adoptive cell therapy.
Eric M. Ostertag, Devon Shedlock
Filed: 2 Jun 22
Utility
Hyperactive piggybac transposases
1 Nov 22
The present invention provides PiggyBac transposase proteins, nucleic acids encoding the same, compositions comprising the same, kits comprising the same, non-human transgenic animals comprising the same, and methods of using the same.
Eric M. Ostertag, Blair Madison
Filed: 19 Mar 19
Utility
Compositions and methods for directing proteins to specific loci in the genome
18 Oct 22
Disclosed are compositions and methods for directing proteins to specific loci in the genome and uses thereof.
Eric Ostertag, Tseten Yeshi, Xianghong Li
Filed: 16 Jun 16
Utility
Inducible caspases and methods for use
5 Jul 22
The disclosure provides inducible caspase polypeptides, compositions comprising inducible caspase polypeptides and sequences encoding the same, cells modified to express the polypeptides and compositions of the disclosure, as well as methods of making and methods of using same for adoptive cell therapy.
Eric M. Ostertag, Devon Shedlock
Filed: 6 Oct 17
Utility
Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids
4 Jan 22
Disclosed are compositions for delivering gene editing molecules to a cell.
Paiman Peter Ghoroghchian, Gabriela Romero Uribe, Eric Ostertag
Filed: 28 Apr 17
Utility
Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles
27 Apr 21
Methods of preparing polymersome-encapsulated functional protein suspensions may include thermally blending an amount of a block copolymer with an amount of a low molecular weight polyethylene glycol (PEG) for at least 30 minutes, mixing and cooling a resulting PEG/polymer formulation to room temperature, adding an aliquot of a solution of the functional protein to a sample containing the PEG/polymer formulation, and performing at least three dilution steps in which polymersomes that are generated are progressively saturated with the functional protein.
P. Peter Ghoroghchian, Jivan Namdeo Yewle
Filed: 20 Sep 19
Utility
Site-specific enzymes and methods of use
23 Nov 20
The present invention provides polypeptides related to Ralstonia proteins, nucleic acids encoding the same, compositions comprising the same, kits comprising the same, non-human transgenic animals comprising the same, and methods of using the same.
Eric M. Ostertag, Tseten Yeshi
Filed: 21 Jul 19
Utility
Modified stem cell memory T cells, methods of making and methods of using same
23 Dec 19
The disclosure provides a method of producing modified stem memory T cells (e.g.
Eric Ostertag, Devon Shedlock
Filed: 9 Oct 18
Utility
Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles
28 Oct 19
Methods of preparing polymersome-encapsulated functional protein suspensions may include thermally blending an amount of a block copolymer with an amount of a low molecular weight polyethylene glycol (PEG) for at least 30 minutes, mixing and cooling a resulting PEG/polymer formulation to room temperature, adding an aliquot of a solution of the functional protein to a sample containing the PEG/polymer formulation, and performing at least three dilution steps in which polymersomes that are generated are progressively saturated with the functional protein.
P. Peter Ghoroghchian, Jivan Namdeo Yewle
Filed: 29 Jun 16
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