13 patents
Utility
Arginine Gingipain Inhibitors
30 Jun 22
Therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A and arginine gingipain B, are disclosed, as well as the use thereof for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
Robert A. Galemmo, Andrei W. Konradi, Casey C. Lynch, Stephen S. Dominy
Filed: 20 Mar 20
Utility
Inhibitors of lysine gingipain
17 May 22
Andrei W. Konradi, Stephen S. Dominy, Casey Crawford Lynch, Craig Coburn, Joseph Vacca
Filed: 4 May 20
Utility
Ketone inhibitors of lysine gingipain
10 May 22
The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis.
Andrei W. Konradi, Robert A. Galemmo, Jr., Stephen S. Dominy, Casey C. Lynch, Leslie J. Holsinger
Filed: 11 Jun 20
Utility
Methods for Detection of Microbial Nucleic Acids In Body Fluids
18 Nov 21
Methods for detecting microbial nucleic acids in a body fluid of a subject are provided.
Debasish Raha, Leslie J. Holsinger, Stephen S. Dominy, Casey C. Lynch
Filed: 27 Sep 19
Utility
Aminopyridine Compounds and Methods for the Preparation and Use Thereof
4 Nov 21
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
Andrei W. Konradi, Robert A. Galemmo, JR., Casey C. Lynch
Filed: 8 Jul 21
Utility
Aminopyridine compounds and methods for the preparation and use thereof
13 Jul 21
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
Andrei W. Konradi, Robert A. Galemmo, Jr., Casey C. Lynch
Filed: 8 Nov 19
Utility
Ketone Inhibitors of Lysine Gingipain
25 Feb 21
The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis.
Andrei W. Konradi, Robert A. Galemmo, JR., Stephen S. Dominy, Casey C. Lynch, Leslie J. Holsinger
Filed: 11 Jun 20
Utility
Inhibitors of arginine gingipain
2 Feb 21
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
Andrei Konradi, Stephen S. Dominy, Casey C. Lynch, Craig Coburn, Joseph Vacca
Filed: 9 May 18
Utility
Inhibitors of Lysine Gingipain
21 Jan 21
Andrei W. Konradi, Stephen S. Dominy, Casey Crawford Lynch, Craig Coburn, Joseph Vacca
Filed: 4 May 20
Utility
Ketone inhibitors of lysine gingipain
3 Aug 20
The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis.
Andrei W. Konradi, Robert A. Galemmo, Jr., Stephen S. Dominy, Casey C. Lynch, Leslie J. Holsinger
Filed: 13 Mar 19
Utility
Inhibitors of lysine gingipain
8 Jun 20
Andrei W. Konradi, Stephen S. Dominy, Casey Crawford Lynch, Craig Coburn, Joseph Vacca
Filed: 29 Apr 19
Utility
Aminopyridine Compounds and Methods for the Preparation and Use Thereof
13 May 20
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
Andrei W. Konradi, Robert A. Galemmo, JR., Casey C. Lynch
Filed: 7 Nov 19
Utility
Inhibitors of Lysine Gingipain
23 Oct 19
Andrei W. Konradi, Stephen S. Dominy, Casey Crawford Lynch, Craig Coburn, Joseph Vacca
Filed: 29 Apr 19
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