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APVO Aptevo Therapeutics

APP
Utility
Prostate-specific Membrane Antigen Binding Proteins and Related Compositions and Methods
1 Apr 21
The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (PSMA) and are useful for the treatment of prostate cancer (e.g., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (BPH).
John W. BLANKENSHIP, Elaine Todd SEWELL, Philip TAN
Filed: 11 May 20
APP
Utility
Single-chain Multivalent Binding Proteins with Effector Function
11 Nov 20
Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.
Peter Armstrong THOMPSON, Jeffrey A. LEDBETTER, Martha Susan HAYDEN-LEDBETTER, Laura Sue GROSMAIRE, Robert BADER, William BRADY
Filed: 22 Dec 19
APP
Utility
Antigen Binding Proteins Binding to 5T4 and 4-1BB and Related Compositions and Methods
15 Jul 20
The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB.
David Bienvenue, Gabriela Hernandez-Hoyos, Lynda Misher, Danielle Mitchell, Peter Ellmark, Anna Sall, Christina Furebring, Laura von Schantz, Sara Fritzell, Laura Varas
Filed: 19 Jul 18
GRANT
Utility
Methods of treatment of CD123 overexpressing disorders
8 Jun 20
The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain.
Gabriela Hernandez-Hoyos, Elaine T. Sewell, Catherine J. McMahan, David Bienvenue, John W. Blankenship, Danielle Mitchell, Peter Pavlik
Filed: 21 Mar 18
APP
Utility
CD123 Binding Proteins and Related Compositions and Methods
27 May 20
The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain.
Gabriela Hernandez-Hoyos, Elaine T. Sewell, Catherine J. McMahan, David Bienvenue, John W. Blankenship, Danielle Mitchell, Peter Pavlik
Filed: 20 Sep 17
APP
Utility
Oncofetal Antigen Binding Proteins and Related Compositions and Methods
18 Dec 19
The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB.
David Bienvenue, Gabriela Hernandez-Hoyos, Lynda Misher, Danielle Mitchell, Peter Ellmark, Anna Sall, Christina Furebring, Laura von Schantz, Sara Fritzell, Laura Varas
Filed: 20 Feb 19
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