16 patents
Utility
Encapsulated Rna Replicons and Methods of Use
28 Dec 23
The disclosure relates to oncolytic virus derived replicons and capsidation of the same.
Lorena LERNER, Edward M. KENNEDY, Jennifer S. LEE
Filed: 28 May 21
Utility
Oncolytic Viral Vectors and Uses Thereof
3 Aug 23
Oncolytic viral vectors that incorporate one or more of the following features: viral replication restriction by insertion of microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle.
Mitchell H. FINER, Lorena LERNER, Christophe QUÉVA, Edward KENNEDY
Filed: 7 Feb 23
Utility
ANTI-DLL3 Antibodies and Methods of Use
20 Jul 23
The present disclosure provides anti-DLL3 binding constructs, such as anti-DLL3 single domain antibodies, as well as polynucleotide encoding the same.
Gholamreza HASSANZADEH GHASSABEH, Lorena LERNER, Sonia FEAU, Christophe QUÉVA
Filed: 5 May 21
Utility
Oncolytic Viral Vectors and Uses Thereof
13 Apr 23
The present disclosure relates to recombinant viral vectors for the treatment and prevention of cancer.
Kenneth P. GREENBERG, Mitchell H. FINER
Filed: 18 Aug 22
Utility
Oncolytic viral vectors and uses thereof
28 Mar 23
Oncolytic viral vectors that incorporate one or more of the following features: viral replication restriction by insertion of microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle.
Mitchell H. Finer, Lorena Lerner, Christophe Quéva, Edward Kennedy
Filed: 26 Jul 18
Utility
Dual Viruses and Dual Oncolytic Viruses and Methods of Treatment
1 Dec 22
The present disclosure provides dual viruses capable of producing a primary virus and a secondary virus, and dual oncolytic viruses capable of producing a primary oncolytic virus and a secondary oncolytic virus.
Edward M. KENNEDY, Lorena LERNER, Christophe QUEVA, Craig A. STRATHDEE, Jennifer S. LEE
Filed: 9 Oct 20
Utility
Oncolytic viral vectors and uses thereof
27 Sep 22
The present disclosure relates to recombinant viral vectors for the treatment and prevention of cancer.
Kenneth P. Greenberg, Mitchell H. Finer
Filed: 10 Jul 19
Utility
Encapsulated Rna Polynucleotides and Methods of Use
21 Apr 22
The present disclosure relates to recombinant RNA molecules encoding an oncolytic virus.
Lorena LERNER, Edward M. KENNEDY, Mitchell H. FINER, Christophe QUÉVA
Filed: 3 Jan 20
Utility
Encapsulated Polynucleotides and Methods of Use
30 Dec 21
The present disclosure relates to polynucleotides comprising a nucleic acid sequence encoding a replication competent viral genome, wherein the polynucleotide is capable of producing a replication competent virus when introduced into a cell by a non-viral delivery vehicle.
Mitchell H. FINER, Edward KENNEDY, Lorena LERNER
Filed: 13 Nov 19
Utility
Oncolytic viral delivery of therapeutic polypeptides
3 Aug 21
Described herein are pseudotyped oncolytic viruses comprising nucleic acids encoding an engager molecule.
Luke Evnin, Mitchell H. Finer
Filed: 28 Jan 20
Utility
Oncolytic Viral Delivery of Therapeutic Polypeptides
25 Mar 21
Described herein are oncolytic viruses comprising one or more nucleic acids encoding an engager molecule.
Mitchell H. FINER, Luke EVNIN
Filed: 28 Dec 18
Utility
Encapsulated Polynucleotides and Methods of Use
15 Jul 20
The present disclosure relates to polynucleotides comprising a nucleic acid sequence encoding a replication competent viral genome, wherein the polynucleotide is capable of producing a replication competent virus when introduced into a cell by a non-viral delivery vehicle.
Mitchell H. FINER, Edward M. KENNEDY, Lorena LERNER
Filed: 12 Jul 18
Utility
Oncolytic Viral Vectors and Uses Thereof
1 Jul 20
The present disclosure relates to recombinant viral vectors for the treatment and prevention of cancer.
Mitchell H. FINER, Lorena LERNER, Christophe QUÉVA, Edward KENNEDY
Filed: 25 Jul 18
Utility
Oncolytic Viral Delivery of Therapeutic Polypeptides
20 May 20
Described herein are pseudotyped oncolytic viruses comprising nucleic acids encoding an engager molecule.
Luke EVNIN
Filed: 27 Jan 20
Utility
Oncolytic Viral Vectors and Uses Thereof
13 May 20
The present disclosure relates to recombinant viral vectors for the treatment and prevention of cancer.
Kenneth P. GREENBERG, Mitchell H. FINER
Filed: 9 Jul 19
Utility
Oncolytic viral delivery of therapeutic polypeptides
30 Mar 20
Described herein are pseudotyped oncolytic viruses comprising nucleic acids encoding an engager molecule.
Luke Evnin
Filed: 24 Oct 18
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