20 patents
Utility
Antibody Conjugates of Toll-like Receptor Agonists
13 Oct 22
Sean Wesley SMITH, Craig Alan COBURN
Filed: 12 Sep 19
Utility
Anti-mesothelin Antibodies and Immunoconjugates Thereof
11 Aug 22
Anti-mesothelin antibodies and conjugates comprising such antibodies are disclosed herein as well as the use of such conjugates in the treatment of disease, such as cancer.
Brenda STEVENS, Peter Robert BAUM, Robert DUBOSE, Valerie ODEGARD
Filed: 18 Jun 20
Utility
Cyclic Amino-pyrazinecarboxamide Compounds and Uses Thereof
2 Jun 22
Cyclic amino-pyrazinecarboxamide compounds, salts, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein.
Sean Wesley SMITH, Craig Alan COBURN
Filed: 5 Mar 20
Utility
Substituted Benzazepine Compounds, Conjugates, and Uses Thereof
17 Feb 22
Benzazepine compounds and salts thereof, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein.
Craig Alan COBURN, Sean Wesley SMITH
Filed: 12 Sep 19
Utility
Nectin-4 antibody conjugates and uses thereof
23 Nov 21
The present disclosure provides conjugates of anti-Nectin-4 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating cancer with the conjugates.
Peter R. Baum, Robert Dubose, Valerie Odegard, Brenda Stevens, Philip Tan
Filed: 19 Feb 21
Utility
NECTIN-4 Antibody Conjugates and Uses Thereof
9 Sep 21
The present disclosure provides conjugates of anti-Nectin-4 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating cancer with the conjugates.
Peter R. Baum, Robert Dubose, Valerie Odegard, Brenda Stevens, Philip Tan
Filed: 19 Feb 21
Utility
ALK5 Inhibitors, Conjugates, and Uses Thereof
27 May 21
Compounds, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein.
Sean Wesley Smith, Craig Alan Coburn, Robert Finley Dubose
Filed: 2 Apr 19
Utility
Compositions and Methods for the Treatment of Viral Infections
27 May 21
Various compositions are disclosed for the treatment of viral infections.
Peter Armstrong Thompson, Valerie Odegard, Robert Finley Dubose, Sean Wesley Smith, Craig Alan Coburn
Filed: 24 Jun 20
Utility
ALK5 Inhibitors, Conjugates, and Uses Thereof
13 May 21
ALK5 inhibitor compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein.
Sean Wesley Smith, Craig Alan Coburn, Peter Robert Baum, Robert Finley Dubose
Filed: 16 Jul 20
Utility
TGFSSR1 Inhibitor-asgr Antibody Conjugates and Uses Thereof
6 May 21
Various conjugates and compositions thereof are disclosed for use in the treatment of a liver disease, such as liver cancer and liver fibrosis.
Peter R. BAUM, Robert DUBOSE, Valerie ODEGARD, Philip TAN, Peter A. THOMPSON, Sean W. SMITH, Brenda STEVENS
Filed: 9 Oct 20
Utility
Conjugates and Methods of Use Thereof for Selective Delivery of Immune-modulatory Agents
22 Apr 21
Various compositions are disclosed.
Peter Armstrong Thompson, Robert Finley Dubose, Peter Robert Baum, Valerie Odegard
Filed: 23 Apr 20
Utility
Formulations of Benzazepine Conjugates and Uses Thereof
18 Mar 21
Aqueous formulations comprising conjugates that comprise a compound comprising benzazepine or a benzazepine-like structure conjugated to a polypeptide are provided, as well as methods of treatment using the aqueous formulations.
Sean Wesley Smith, Sateesh Natarajan
Filed: 14 Aug 20
Utility
Construct-peptide Compositions and Methods of Use Thereof
24 Jun 20
Construct-peptide compositions are disclosed.
Peter Armstrong Thompson
Filed: 1 Feb 18
Utility
Antibody Conjugates of Immune-modulatory Compounds and Uses Thereof
24 Jun 20
Antibody conjugates of immune-modulatory compounds and pharmaceutical compositions for use in the treatment of disease, such as fibrotic diseases, autoimmune, or autoinflammatory diseases, are disclosed herein.
Peter Armstrong THOMPSON, Badreddin EDRIS, Craig Alan COBURN, Peter Robert BAUM, Valerie ODEGARD
Filed: 6 Jun 18
Utility
Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates
15 Apr 20
Methods and conjugates are disclosed for alleviating toxicity(ies) associated with administration of immune-stimulatory conjugates, and in particular for alleviating toxicity(ies) associated with intravenous administration of such conjugates.
Valerie Odegard, Peter Baum, Sean Wesley Smith, Craig Alan Coburn, Peter Armstrong Thompson
Filed: 10 Sep 19
Utility
Benzazepine Compounds, Conjugates, and Uses Thereof
29 Jan 20
Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein.
Craig Alan Coburn, Peter Robert Baum, Sean Wesley Smith
Filed: 6 Aug 19
Utility
Benzazepine compounds, conjugates, and uses thereof
30 Dec 19
Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein.
Craig Alan Coburn, Peter Robert Baum, Sean Wesley Smith
Filed: 6 May 18
Utility
Tumor Targeting Conjugates and Methods of Use Thereof
6 Nov 19
Various compositions are disclosed.
Peter Armstrong Thompson, Philip Huat Seng Tan, Peter Robert Baum, Robert Finley Dubose, Craig Alan Coburn, Sean Wesley Smith
Filed: 25 Jan 18
Utility
Benzazepine compounds, conjugates, and uses thereof
14 Oct 19
Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein.
Craig Alan Coburn, Peter Robert Baum, Sean Wesley Smith
Filed: 11 Feb 19
Utility
Benzazepine compounds, conjugates, and uses thereof
30 Sep 19
Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein.
Craig Alan Coburn, Peter Robert Baum, Sean Wesley Smith
Filed: 11 Feb 19
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