13 patents
Utility
tRNA SYNTHETASES AND METHODS OF USE THEREOF
21 Dec 23
This disclosure provides engineered aminoacyl tRNA synthetases and tRNAs for efficient production of proteins containing non-standard amino acids.
Yi Zhang
Filed: 7 Apr 23
Utility
Coordinated Coexpression of Thrombin
26 Oct 23
The present invention provides methods of producing thrombin using coordinated coexpression systems, and particularly inducible coexpression systems, capable of controlled induction of expression of each gene product required for the production of thrombin.
Sean McClain, Mark Valasek, Andras Gruber
Filed: 1 May 23
Utility
Polypeptide Cleavage Methods
25 May 23
Methods and constructs for the cleavage of polypeptides at one or more specific positions within the polypeptide are provided.
Tyler Nusca, Johan Kers, Matthew Weinstock, Michelle Slind, Amy Doerner, Michael Cammarata, Abigail Ward
Filed: 20 Apr 21
Utility
Proximity Assay
16 Mar 23
The present disclosure provides assay methods for the detection and/or quantification of an analyte in a sample.
Jia Liu
Filed: 11 Feb 21
Utility
C-peptides and Proinsulin Polypeptides Comprising the Same
9 Mar 23
A connecting polypeptide has SEQ ID NO:73.
AMY DOERNER, Michael Cammarata, Tyler Nusca, Suzanne Sprunger, Melissa Patterson
Filed: 6 Jul 22
Utility
Activity-specific Cell Enrichment
2 Mar 23
An activity-specific cell-enrichment method, capable of selection of high-performing host cells and/or expression vectors from a genetically diverse pool of host cells that can comprise expression vectors is provided.
Jia Liu
Filed: 15 Jan 21
Utility
Vectors for Use In an Inducible Coexpression System
17 Nov 22
The present invention provides expression vectors for use in an inducible coexpression system, capable of controlled induction of expression of each gene product.
Sean McClain, Mark Valasek, Philip Barish, Jeremy Minshull
Filed: 19 May 22
Utility
Methods for Inducible Expression
24 Mar 22
The present invention is an inducible coexpression system, capable of controlled induction of expression of each gene product.
Sean McClain, Mark Valasek
Filed: 6 Dec 21
Utility
C-peptides and Proinsulin Polypeptides Comprising the Same
23 Sep 20
A connecting polypeptide has SEQ ID NO:73.
Amy Doerner, Michael Cammarata, Fred Larimore, Tyler Nusca, Suzanne A. Sprunger, Melissa Patterson
Filed: 3 May 20
Utility
Expression Constructs, Host Cells, and Methods for Producing Insulin
26 Aug 20
A cell for producing insulin includes an E. coli host cell and a polynucleotide designed for production of insulin disposed within the E. coli host cell.
Sean McClain, Philip Barish
Filed: 10 May 20
Utility
Host Cells for Use In an Inducible Coexpression System
3 Jun 20
The present invention provides host cells for use in an inducible coexpression system that is capable of controlled induction of expression of each gene product.
Sean McClain, Mark Valasek
Filed: 12 Feb 20
Utility
Coordinated Coexpression of Thrombin
26 Feb 20
The present invention provides methods of producing thrombin using coordinated coexpression systems, and particularly inducible coexpression systems, capable of controlled induction of expression of each gene product required for the production of thrombin.
Sean McClain, Mark Valasek, Andras Gruber
Filed: 4 Nov 19
Utility
Methods for Inducible Expression
29 Jan 20
The present invention is an inducible coexpression system, capable of controlled induction of expression of each gene product.
Sean McClain, Mark Valasek
Filed: 6 Oct 19
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