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SLGL Sol-Gel Technologies

APP
Utility
Stabilized Microcapsules, Method of Their Preparation and Uses Thereof
25 Nov 21
The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.
Ofer TOLEDANO, Karine NEIMANN, Danil FINKEL-MOISEEV, Maya ERLICH, Dorit MARCO
Filed: 23 May 21
APP
Utility
Stabilized Microcapsules, Method of Their Preparation and Uses Thereof
25 Nov 21
The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.
Ofer Toledano, Karine Neimann, Danil Finkel-Moiseev, Maya Erlich, Dorit MARCO
Filed: 23 May 21
APP
Utility
Stabilized Microcapsules, Method of Their Preparation and Uses Thereof
25 Nov 21
The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.
Ofer TOLEDANO, Karine NEIMANN, Danil FINKEL-MOISEEV, Maya ERLICH, Dorit MARCO
Filed: 23 May 21
APP
Utility
Compositions Comprising Tapinarof for the Treatment of Pruritis
11 Nov 21
The present invention, in some embodiments thereof, relates to a topical composition for use in treating, preventing, alleviating and/or ameliorating pruritus, wherein the composition comprises tapinarof and the pruritus is not associated with atopic dermatitis, psoriasis or any combination thereof.
Marcel ZIGHELBOIM, Moshe ARKIN, Karine NEIMANN, Hila HAKAK DJERBI
Filed: 6 May 21
APP
Utility
Treatment of Skin Disorders with Compositions Comprising an Egfr Inhibitor
11 Nov 21
This invention relates to compositions and methods of treatment of skin or mucosal disorders by administration of compositions comprising at least one EGFR inhibitor, such as topical compositions comprising erlotinib.
Moshe ARKIN, Marcel ZIGHELBOIM, Ori NOV, Ofer TOLEDANO, Karine NEIMANN, Asher Cachlon
Filed: 20 Jun 21
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Utility
Treatment of Alopecia
14 Oct 21
The present invention is directed to a composition comprising aryl hydrocarbon receptor (AhR) agonists and combinations for the prevention and treatment of alopecia and hair loss, e.g. when such conditions are caused by chemotherapy, radiation therapy or hormone replacement therapy.
Ori Nov, Marcel Zighelboim, Karine Neimann
Filed: 12 Apr 21
APP
Utility
Core Stabilized Microcapsules, Method of Their Preparation and Uses Thereof
23 Sep 21
The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
Filed: 7 Jun 21
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Utility
Compositions Comprising Benzoyl Peroxide for the Treatment of Gastrointestinal Disorder
16 Sep 21
The present invention relates to the treatment, prevention or alleviation of a gastrointestinal disorder caused by one or more intestinal helminths, said treatment, prevention or alleviation comprises administering a topical composition comprising a peroxide to a subject in need thereof.
Ori NOV, Karine NEIMANN, Asher CACHLON
Filed: 16 Mar 21
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Treatment of Skin Disorders with Topical Roflumilast Combination Compositions
5 Aug 21
Moshe ARKIN, Marcel ZIGHELBOIM, Karine NEIMANN
Filed: 3 Feb 21
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Compositions Comprising Roflumilast for Treating Hidradenitis Suppurativa and Prurigo Nodularis
5 Aug 21
Moshe Arkin, Marcel Zighelboim, Karine Neimann, Hila Hakak Djerbi
Filed: 3 Feb 21
GRANT
Utility
Core stabilized microcapsules, method of their preparation and uses thereof
27 Jul 21
The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
Filed: 19 Mar 18
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Utility
Methods and Compositions for the Treatment of Granuloma Annulare or Subcutaneous Inflammation and Non-infection Granulomatous Diseases
15 Jul 21
The present invention, in some embodiments thereof, relates to topical compositions and methods of treatment, prevention and/or amelioration of granuloma annulare, a non-infection granulomatous disease, or a subcutaneous inflammation by topical or intralesional administration of compositions comprising tapinarof.
Marcel Zighelboim, Hila Hakak Djerbi, Karine Neimann
Filed: 13 Jan 21
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Utility
Method for Treatment of Rosacea In Patients Aged 65 Years and Older
10 Jun 21
A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 21 Jan 21
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Utility
Method for Providing Early Onset of Action In the Treatment of Rosacea
20 May 21
A regimen is described for providing early onset of action in the therapeutic treatment of rosacea including topically applying a pharmaceutical composition to the skin of a subject in need of said treatment.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 25 Jan 21
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Utility
Methods and Compositions for the Treatment of Acne
22 Apr 21
The present application is directed to regimens, methods of treatment, and compositions for the treatment of acne in a subject suffering therefrom.
Ofer Toledano, Ofra Levy-Hacham, Rinat Mizrahi
Filed: 30 Dec 20
GRANT
Utility
Process for the preparation of glycopyrrolate tosylate
23 Mar 21
The present application provides novel process for the preparation of glycopyrrolate tosylate.
Stephen Cherkez, Veera Reddy Arava, Madhusudhanarao Rayapureddi, Venkateswarlu Jasti
Filed: 12 Mar 18
GRANT
Utility
Method for providing early onset of action in the treatment of rosacea
16 Mar 21
A regimen is described for providing early onset of action in the therapeutic treatment of rosacea including topically applying a pharmaceutical composition to the skin of a subject in need of said treatment.
Ofer Toledano, Ofra Levy-Hacham, Ori Nov, Vered Ram
Filed: 19 Feb 20
GRANT
Utility
Process for the preparation of glycopyrrolate tosylate
16 Mar 21
This invention is directed to a process for the preparation of glycopyrrolate tosylate comprising the step of reacting a halogen salt of glycopyrrolate with tosylic acid or a salt thereof in the presence of hydrogen peroxide and at least one unsaturated organic agent.
Veera Reddy Arava, Madhusudhanarao Rayapureddi, Venkateswarlu Jasti
Filed: 26 Jul 18
GRANT
Utility
Method for treatment of rosacea in patients aged 65 years and older
2 Mar 21
A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.
Ofer Toledano, Ofra Levy-Hacham, Ori Nov, Vered Ram
Filed: 19 Feb 20
APP
Utility
Method for Preparing Particles Comprising Metal Oxide Coating and Particles with Metal Oxide Coating
14 Jan 21
The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer.
Ofer TOLEDANO, Haim Bar-Simantov, Nissim Bilman, Leora Shapiro, Raed Abu-Reziq, Hanan Sertchook
Filed: 10 Sep 20
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