12 patents
Utility
Cyclic Cell Penetrating Peptides
5 Oct 23
The present disclosure is directed to cell penetrating peptides, including cyclic cell penetrating peptides with high cytosolic delivery efficiency and reduced toxicity that are able to effectively deliver cargo inside a cell to treat a variety of conditions and diseases.
Patrick Dougherty, Ziqing Qian, Mahboubeh Kheirabadi
Filed: 30 Mar 23
Utility
Synthesis of Fmoc-protected Morpholino Monomers and Oligomers
30 Mar 23
The present disclosure provides the synthesis of phosphorodiamidate morpholino oligomers (PMOs) in high purity, yield, and efficiency from Fmoc-protected morpholino monomers, e.g., Fmoc morpholino monomer G.
Kyle A. Totaro, Ziqing Qian
Filed: 10 Jun 22
Utility
Antigen-binding and Antigen Degradation Constructs
26 Jan 23
Degradation compounds include a cyclic cell penetrating peptide (cCPP) and a degradation construct.
Natarajan SETHURAMAN, Patrick DOUGHERTY, Byung-Kwon CHOI, Nicholas Emerson LONG, Ziqing QIAN
Filed: 9 May 22
Utility
Compositions for Delivery of Antisense Compounds
19 Jan 23
Provided herein are compounds comprising cyclic cell penetrating peptides and antisense compounds.
Ziqing Qian, Xiang Li, Mahboubeh Kheirabadi, Mohanraj Dhanabal, Haoming Liu, Xiulong Shen, Kimberli Kamer, Natarajan Sethuraman
Filed: 21 Dec 20
Utility
Cell Penetrating Peptides and Methods of Making and Using Thereof
9 Jun 22
Disclosed herein are compounds having activity as cell penetrating peptides.
Dehua PEI, Ziqing QIAN
Filed: 19 Nov 21
Utility
Compositions and Methods for Treating Mitochondrial Neurogastrointestinal Encephalopathy
3 Feb 22
Disclosed herein are compositions and methods of treating disclosure provides for compounds for use in treating Mitochondrial Neurogastrointestinal Encephalopathy Syndrome (MNGIE).
Natarajan SETHURAMAN, Jason RUTH, Louis A. TARTAGLIA, Dehua PEI, Ziqing QIAN
Filed: 6 Oct 21
Utility
Cell penetrating peptides and methods of making and using thereof
18 Jan 22
Disclosed herein are compounds having activity as cell penetrating peptides.
Dehua Pei, Ziqing Qian
Filed: 20 Apr 20
Utility
Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
9 Nov 21
Disclosed herein are compositions and methods of treating disclosure provides for compounds for use in treating Mitochondrial Neurogastrointestinal Encephalopathy Syndrome (MNGIE).
Natarajan Sethuraman, Jason Ruth, Lou A. Tartaglia, Dehua Pei, Ziqing Qian
Filed: 17 Mar 20
Utility
Cell Penetrating Peptides and Methods of Making and Using Thereof
9 Dec 20
Disclosed herein are compounds having activity as cell penetrating peptides.
Dehua PEI, Ziqing QIAN
Filed: 19 Apr 20
Utility
Compositions and Methods for Treating Mitochondrial Neurogastrointestinal Encephalopathy
11 Nov 20
Disclosed herein are compositions and methods of treating disclosure provides for compounds for use in treating Mitochondrial Neurogastrointestinal Encephalopathy Syndrome (MNGIE).
Natarajan SETHURAMAN, Jason RUTH, Lou A. TARTAGLIA, Dehua PEI, Ziqing QIAN
Filed: 16 Mar 20
Utility
Cell penetrating peptides and methods of making and using thereof
26 Oct 20
Disclosed herein are compounds having activity as cell penetrating peptides.
Dehua Pei, Ziqing Qian
Filed: 22 Nov 16
Utility
Cell penetrating peptides and methods of making and using thereof
20 Apr 20
Disclosed herein are compounds having activity as cell penetrating peptides.
Dehua Pei, Ziqing Qian
Filed: 20 May 15
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