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PRAX Praxis Precision Medicines

APP
Utility
Formulations of T-type Calcium Channel Modulators and Methods of Use Thereof
20 Jan 22
Described herein, in part, are dosage forms and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)).
Kiran REDDY, Margaret S. LEE, Gabriel Maurice BELFORT, Sapna Makhija GARAD, Mahesh PADVAL, Randall WAGNER, Marion WITTMANN
Filed: 28 Jul 21
APP
Utility
Ion Channel Modulators
30 Dec 21
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
Filed: 27 Sep 19
APP
Utility
Compounds and Their Methods of Use
18 Nov 21
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Kiran Reddy, Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella
Filed: 4 Apr 18
APP
Utility
Compounds and Their Methods of Use
24 Jun 21
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
Filed: 28 Nov 17
APP
Utility
Compounds and Their Methods of Use
24 Jun 21
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
Filed: 28 Nov 17
APP
Utility
Ion Channel Modulators
10 Jun 21
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron, Carlos Loya
Filed: 25 Nov 20
APP
Utility
Ion Channel Modulators
3 Jun 21
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella, Kiran Reddy, Marion Wittmann
Filed: 30 May 19
GRANT
Utility
3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator
25 May 21
Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella
Filed: 24 Nov 20
APP
Utility
T-type Calcium Channel Modulators and Methods of Use Thereof
6 May 21
Described herein are compounds useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy) and mood disorders.
Kiran Reddy, Terence John O'Brien, Pablo Miguel Casillas-Espinosa, Kim Powell
Filed: 21 Dec 17
APP
Utility
Ion Channel Modulators
25 Mar 21
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella
Filed: 24 Nov 20
GRANT
Utility
Salts and crystal forms of GABA
23 Feb 21
The invention relates to salts of Compound 1, crystalline forms thereof, methods of their preparation, pharmaceutical compositions thereof and methods of their use.
Nelson B. Olivier, Kiran Reddy, Gabriel Martinez Botella, Magnus Ronn, Paul A. Laskar
Filed: 27 Nov 19
APP
Utility
Ion Channel Modulators
2 Dec 20
Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella, Kiran Reddy
Filed: 28 May 20
APP
Utility
Compounds and Their Methods of Use
2 Dec 20
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
Filed: 27 May 20
APP
Utility
Ion Channel Modulators
2 Dec 20
Andrew Mark Griffin, Brian Edward Marron, Gabriel Martinez Botella, Kiran Reddy
Filed: 28 May 20
APP
Utility
Methods for the Treatment of Depression
14 Oct 20
The invention relates to methods of treating depression with Compound 1 or pharmaceutically acceptable salts thereof.
Nicholas DEMARTINIS, Carlos LOYA
Filed: 24 Jun 20
APP
Utility
Salts and Crystal Forms of Gaba-a Positive Allosteric Modulator
12 Aug 20
The invention relates to salts of Compound 1, crystalline forms thereof, methods of their preparation, pharmaceutical compositions thereof and methods of their use
Nelson B. OLIVIER, Kiran REDDY, Gabriel Martinez BOTELLA, Magnus RONN, Paul A. LASKAR
Filed: 26 Nov 19
APP
Utility
Compounds and Their Methods of Use
5 Aug 20
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
Filed: 12 Feb 18
APP
Utility
Methods for the Treatment of Depression
17 Jun 20
The invention relates to methods of treating depression with Compound 1 or pharmaceutically acceptable salts thereof.
Carlos LOYA, Nicholas DEMARTINIS
Filed: 15 Dec 19
APP
Utility
Compounds and Their Methods of Use
10 Jun 20
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Kiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron
Filed: 14 Aug 18
APP
Utility
Methods of Treating Epilepsy and Neurodevelopmental Disorders
18 Mar 20
The present invention is directed to, in part, methods of preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current.
Gabriel Martinez Botella, Kiran Reddy, Marion Wittmann
Filed: 15 May 18
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