97 patents
Page 3 of 5
Utility
Methods for Assaying Binding Affinity
2 Sep 21
Disclosed herein is a method for assaying binding affinity between a first molecule and a second molecule in a micro-fluidic device.
Paul M. Lebel, Troy A. Lionberger, Kevin T. Chapman
Filed: 11 Mar 21
Utility
Methods, systems and devices for selection and generation of genome edited clones
31 Aug 21
Methods are described herein for isolating clonal populations of cells having a defined genetic modification.
Gregory G. Lavieu, Annamaria Mocciaro, Xiao Guan Radstrom, Jason M. McEwen, Magali Soumillon, J. Tanner Nevill, Volker L. S. Kurz, Patricia A. Dyck, Ravi K. Ramenani
Filed: 28 Jan 19
Utility
Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof
24 Aug 21
A microfluidic device can comprise a plurality of interconnected microfluidic elements.
Keith J. Breinlinger, Andrew W. McFarland, J. Tanner Nevill
Filed: 7 Aug 18
Utility
Screening Plant Protoplasts for Disease Resistant Traits
5 Aug 21
Methods for screening plant cells, particularly plant protoplasts, for disease resistant traits, and kits for performing such methods are provided.
Troy A. LIONBERGER, Volker L.S. KURZ
Filed: 4 Jan 21
Utility
Apparatuses, systems and methods for imaging micro-objects
3 Aug 21
The present disclosure relates to an optical apparatus for imaging and/or manipulating micro-objects in a microfluidic device, such as a light-actuated microfluidic (LAMF) device, and related systems and methods.
Paul M. Lundquist, Paul M. Lebel, Phillip Ronald Thomas Jess
Filed: 17 May 19
Utility
Light Sequencing and Patterns for Dielectrophoretic Transport
15 Jul 21
Optically-actuated microfluidic devices permit the use of spatially-modulated light to manipulate micro-objects such as biological cells.
Troy A. Lionberger, Brandon R. Bruhn, John A. Tenney, Eric D. Hobbs
Filed: 5 Jun 20
Design
Display screen with graphical user interface
13 Jul 21
Pavan Ramkumar, Michael J. Stone, Keith J. Breinlinger
Filed: 1 Feb 19
Utility
Automated Detection and Characterization of Micro-objects In Microfluidic Devices
8 Jul 21
Methods are provided for the automated detection, characterization, and selection of micro-objects in a microfluidic device.
John A. TENNEY, Thomas M. VETTERLI, Hansohl E. KIM
Filed: 24 Nov 20
Utility
Covalently modified surfaces, kits, and methods of preparation and use
18 May 21
In biosciences and related fields, it can be useful to modify surfaces of apparatuses, devices, and materials that contact biomaterials such as biomolecules and biological micro-objects.
Randall D. Lowe, Jr., Alexander J. Mastroianni, Mark P. White, Gregory G. Lavieu, Kristin G. Beaumont
Filed: 20 Nov 18
Utility
Lateral/vertical Transistor Structures and Process of Making and Using Same
6 May 21
A microfluidic device can include a base an outer surface of which forms one or more enclosures for containing a fluidic medium.
Eric D. Hobbs, Justin K. Valley
Filed: 5 Oct 20
Utility
Microfluidic Apparatus Having an Optimized Electrowetting Surface and Related Systems and Methods
22 Apr 21
Microfluidic devices having an electrowetting configuration and an optimized droplet actuation surface are provided.
Randall D. LOWE, Jr., Shao Ning PEI, Jian GONG, Alexander J. MASTROIANNI, Jason M. MCEWEN, Justin K. VALLEY
Filed: 27 Aug 20
Utility
Methods for Preparation of Nucleic Acid Sequencing Libraries
22 Apr 21
Processes and kits are provided for producing sequence specific fragments of nucleic acid molecules, whether from a genome or transcriptome, where one end of the molecule is highly diverse and/or the full-length molecule, whether a gene or a mRNA, is too long for it to be sequenced using currently available sequencing methods.
Ravi K. RAMENANI, Duane SMITH, Jason M. McEWEN, Magali SOUMILLON
Filed: 25 Sep 20
Utility
Freezing and archiving cells on a microfluidic device
13 Apr 21
A method of processing and storing biological cells includes introducing a flowable medium into a microfluidic device, the flowable medium including biological cells; sequestering one or more biological cells from the flowable medium in one or more isolation regions of the microfluidic device; and freezing the microfluidic device including the one or more biological cells sequestered therein.
Mark P. White, Kevin T. Chapman, Andrew W. McFarland, Eric D. Hobbs, Randall D. Lowe, Jr.
Filed: 22 Apr 16
Utility
Microfluidic Devices for Optically-Driven Convection and Displacement, Kits and Methods Thereof
8 Apr 21
Apparatuses and methods are described for the use of optically driven bubble, convective and displacing fluidic flow to provide motive force in microfluidic devices.
Volker L.S. Kurz, Troy A. Lionberger, Eric K. Sackmann, Kai W. Szeto, Paul M. Lebel, Brandon R. Bruhn, Keith J. Breinlinger, Eric D. Hobbs, Andrew W. McFarland, J. Tanner Nevill, Xiaohua Wang
Filed: 12 Oct 20
Utility
Mutant IDH1 Specific T Cell Receptor
25 Mar 21
This disclosure relates to the production and use of an isolated, purified and/or recombinant T cell receptor (TCR) that specifically binds to a mutant IDH1 protein, or a fragment thereof, wherein the mutant IDH1 protein or fragment thereof comprises an R132H mutation.
Hideho Okada, Duane Smith, Payal Watchmaker, Yelena Bronevetsky, Ryosuke Naka, Guido K. Stadler, Xiaohua Wang, Kevin T. Chapman
Filed: 7 Aug 20
Utility
Automated Detection and Repositioning of Micro-objects In Microfluidic Devices
25 Mar 21
Methods are provided for the automated detection of micro-objects in a microfluidic device.
Fenglei Du, Paul M. Lundquist, John A. Tenney, Troy A. Lionberger
Filed: 5 Oct 20
Utility
Microfluidic Cell Culture
11 Mar 21
Systems, methods and kits are described for culturing one or more biological cells in a microfluidic device, including provision of nutrients and gaseous components configured to enhance cell growth, viability, portability, or any combination thereof.
Randall D. LOWE, JR., Kristin G. BEAUMONT, Aathavan KARUNAKARAN, Natalie C. MARKS, Jason M. MCEWEN, Mark P. WHITE, J. Tanner NEVILL, Gang F. WANG, Andrew W. MCFARLAND, Daniele Malleo, Keith J. BREINLINGER, Xiao GUAN, Kevin T. CHAPMAN
Filed: 2 Jul 20
Utility
Microfluidic Reporter Cell Assay Methods and Kits Thereof
11 Mar 21
Functional assays using reporter cell assays are described which probe the activity of at least one cell of interest.
Xiao Guan, Mark P. White, Jason M. McEwen, Gang F. Wang, Kevin T. Chapman, Xiaohua Wang, Christine E. Sun
Filed: 14 Jul 20
Utility
In Situ-generated Microfluidic Assay Structures, Related Kits, and Methods of Use Thereof
14 Jan 21
In situ-generated microfluidic capture structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described.
Kristin G. Beaumont, Peter J. Beemiller, Volker L.S. Kurz, Gregory G. Lavieu, Xiaohua Wang, Aathavan Karunakaran
Filed: 22 Jun 20
Utility
Methods, Systems and Kits for In-pen Assays
30 Dec 20
Methods, systems and kits are described herein for detecting the results of an assay.
Troy A. Lionberger, Phillip J. M. Elms, Anupam Singhal, Randall D. Lowe, Jr., Volker L. S. Kurz, Paul M. Lebel
Filed: 14 Apr 20