12 patents
Utility
CD16A binding agents and uses thereof
7 Feb 23
Among other things, the present disclosure provides compounds, compositions thereof, and methods of using the same.
Anna Bunin, Lawrence G. Iben, Douglas Manion, David Adam Spiegel, Matthew Ernest Welsch
Filed: 8 Jan 19
Utility
Prodrugs of riluzole and their method of use
13 Sep 22
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole.
Garry Robert Smith, Allen B. Reitz, Mark McDonnell, Suzie Chen, Matthew D. Vera, Benjamin E. Blass, Jeffrey Claude Pelletier, Venkata N. Velvadapu, Jay Edward Wrobel
Filed: 23 Nov 20
Utility
Use of riluzole, riluzole prodrugs or riluzole analogs with immunotherapies to treat cancers
2 Aug 22
Disclosed are methods of treating cancer using a combination of an immunotherapeutic agent, such as, for example, a PD-1, PD-L1 or CTLA-4 checkpoint inhibitor, and a glutamate modulating agent such as riluzole or trigriluzole.
Vladimir Coric
Filed: 19 May 17
Utility
Prodrugs of lanicemine and their method of use
14 Jun 22
Pharmaceutical compositions of the invention include substituted Lanicemine prodrugs useful for the treatment of conditions associated with dysregulation of NMDA receptor activity such as depression and depressive disorders through the release of Lanicemine, Prodrugs of Lanicemine have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release Lanicemine in the plasma via either an enzymatic or general biophysical release process.
Allen B. Reitz, Jeffery Claude Pelletier
Filed: 22 Nov 17
Utility
Amine prodrugs of pharmaceutical compounds
10 Aug 21
Disclose are amine prodrugs and methods of synthesis thereof.
Anthony Marfat
Filed: 19 Aug 19
Utility
Rimegepant for CGRP related disorders
10 Aug 21
Disclosed are methods of treating CGRP related disorders, e.g., migraine, by administering to a patient in need thereof rimegepant or a pharmaceutically acceptable salt thereof.
Vladimir Coric, Robert Croop
Filed: 27 May 20
Utility
Riluzole prodrugs and their use
6 Jul 21
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole.
Jay Edward Wrobel, Allen B. Reitz, Jeffery Claude Pelletier, Garry Robert Smith, Haiyan Bian
Filed: 20 Nov 19
Utility
Riluzole prodrugs and their use
2 Feb 21
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole.
Jay Edward Wrobel, Allen B. Reitz, Jefferey Claude Pelletier, Garry Robert Smith, Haiyan Bian
Filed: 24 Jun 19
Utility
Prodrugs of riluzole and their method of use
23 Nov 20
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole.
Garry Robert Smith, Allen B. Reitz, Mark McDonnell, Suzie Chen, Matthew D. Vera, Benjamin E. Blass, Jeffrey Claude Pelletier, Venkata N. Velvadapu, Jay Edward Wrobel
Filed: 20 Jan 20
Utility
Prodrugs of riluzole and their method of use
4 May 20
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole.
Jay Edward Wrobel, Allen B. Reitz, Jeffery Claude Pelletier, Garry Robert Smith, Haiyan Bian
Filed: 25 Feb 16
Utility
Prodrugs of riluzole and their method of use
17 Feb 20
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole.
Garry Robert Smith, Allen B. Reitz, Mark Mcdonnell, Suzie Chen, Matthew D. Vera, Benjamin E. Blass, Jeffery Claude Pelletier, Venkata N. Velvadapu, Jay Edward Wrobel
Filed: 3 Aug 17
Utility
Riluzole prodrugs and their use
25 Nov 19
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole.
Jay Edward Wrobel, Allen B. Reitz, Jeffery Claude Pelletier, Garry Robert Smith, Haiyan Bian
Filed: 25 Feb 16
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