212 patents
Page 11 of 11
Utility
PolyAnionic Delivery of Nucleic Acids
15 Jan 20
Michael Heartlein, Frank DeRosa, Shrirang Karve
Filed: 6 Mar 18
Utility
Messenger Rna Vaccines and Uses Thereof
15 Jan 20
The present invention provides, among other things, methods and compositions of formulating nucleic acid-containing nanoparticles for efficient delivery of payload in vivo such that the method and compositions can be used to generate mRNA vaccines.
Shrirang Karve, Zarna Patel, Ashish Sarode, Yi Zhang, Frank DeRosa, Michael Heartlein
Filed: 28 May 19
Utility
Mrna Therapeutic Compositions and Use to Treat Diseases and Disorders
25 Dec 19
Disclosed are compositions and methods for producing therapeutic fusion proteins in vivo.
Michael Heartlein
Filed: 23 May 19
Utility
Cleavable lipids
16 Dec 19
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use.
Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
Filed: 1 Feb 18
Utility
Lipid nanoparticle compositions and methods for mRNA delivery
16 Dec 19
Disclosed herein are compositions and methods for modulating the production of a protein in a target cell.
Braydon Charles Guild, Frank DeRosa, Michael Heartlein
Filed: 2 Jul 19
Utility
Lipid formulations for delivery of messenger RNA
2 Dec 19
Michael Heartlein, Daniel Anderson, Yizhou Dong, Frank DeRosa
Filed: 2 Jul 18
Utility
Biodegradable lipids for delivery of nucleic acids
2 Dec 19
Frank DeRosa, Michael Heartlein
Filed: 6 Jun 18
Utility
Ice-based lipid nanoparticle formulation for delivery of mRNA
11 Nov 19
The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid.
Frank DeRosa, Michael Heartlein, Shrirang Karve
Filed: 9 Nov 17
Utility
Lipid Nanoparticle Compositions and Methods for Mrna Delivery
23 Oct 19
Disclosed herein are compositions and methods for modulating the production of a protein in a target cell.
Braydon Charles Guild, Frank DeRosa, Michael Heartlein
Filed: 2 Jul 19
Utility
Cleavable Lipids
16 Oct 19
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use.
Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
Filed: 24 Jun 19
Utility
Subcutaneous Delivery of Messenger Rna
2 Oct 19
The present invention provides, among other things, methods of formulating nucleic acid-containing nanoparticles with an enzyme to afford efficient delivery of payload to a cell or tissue of interest via subcutaneous administration.
Shrirang Karve, Frank DeRosa, Zarna Bhavsar, Michael Heartlein
Filed: 9 Nov 17
Utility
Multimeric coding nucleic acid and uses thereof
30 Sep 19
The present invention provides, among other things, multimeric coding nucleic acids that exhibit superior stability for in vivo and in vitro use.
Frank DeRosa, Michael Heartlein, Daniel Crawford, Shrirang Karve
Filed: 19 Feb 19