72 patents
Page 4 of 4
Utility
Multimeric oligonucleotide compounds
6 Jul 20
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker.
Eugen Uhlmann, Markus Weber, Romesh R. Subramanian, Thomas Dino Rockel, Arthur M. Krieg
Filed: 29 Aug 18
Utility
Compositions and methods for modulating MECP2 expression
18 May 20
Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of MECP2.
Arthur M. Krieg, Romesh Subramanian, James McSwiggen, Jeannie T. Lee
Filed: 18 Oct 17
Utility
Synergistic enhancement of the delivery of nucleic acids via blended formulations
11 May 20
Disclosed herein are pharmaceutical compositions that comprise “blends” of lipid nanoparticles and related methods of using such blended compositions to deliver polynucleotides to one or more target cells, tissues or organs.
Frank DeRosa, Lianne Smith, Michael Heartlein, Braydon Charles Guild
Filed: 9 Oct 18
Utility
Quantitative assessment for cap efficiency of messenger RNA
20 Apr 20
The present invention provides, among other things, methods of quantitating mRNA capping efficiency, particularly mRNA synthesized in vitro.
Michael Heartlein, Frank DeRosa, Anusha Dias
Filed: 13 Mar 14
Utility
Methods and compositions for delivering mRNA coded antibodies
9 Mar 20
The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody, and wherein the antibody is expressed systemically in the subject.
Michael Heartlein, Frank DeRosa, Anusha Dias, Braydon Charles Guild
Filed: 11 Sep 18
Utility
Liver specific delivery of messenger RNA
2 Mar 20
Disclosed herein are compositions and methods of modulating the expression of gene or the production of a protein by transfecting target cells with nucleic acids.
Frank DeRosa, Michael Heartlein
Filed: 5 Apr 16
Utility
Cleavable lipids
16 Dec 19
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use.
Braydon Charles Guild, Michael Heartlein, Frank DeRosa, Jerry Chi Zhang
Filed: 1 Feb 18
Utility
Lipid nanoparticle compositions and methods for mRNA delivery
16 Dec 19
Disclosed herein are compositions and methods for modulating the production of a protein in a target cell.
Braydon Charles Guild, Frank DeRosa, Michael Heartlein
Filed: 2 Jul 19
Utility
Lipid formulations for delivery of messenger RNA
2 Dec 19
Michael Heartlein, Daniel Anderson, Yizhou Dong, Frank DeRosa
Filed: 2 Jul 18
Utility
Biodegradable lipids for delivery of nucleic acids
2 Dec 19
Frank DeRosa, Michael Heartlein
Filed: 6 Jun 18
Utility
Ice-based lipid nanoparticle formulation for delivery of mRNA
11 Nov 19
The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid.
Frank DeRosa, Michael Heartlein, Shrirang Karve
Filed: 9 Nov 17
Utility
Multimeric coding nucleic acid and uses thereof
30 Sep 19
The present invention provides, among other things, multimeric coding nucleic acids that exhibit superior stability for in vivo and in vitro use.
Frank DeRosa, Michael Heartlein, Daniel Crawford, Shrirang Karve
Filed: 19 Feb 19