28 patents
Utility
Liposomal spherical nucleic acid (SNA) constructs presenting antisense oligonucleotides (ASO) for specific knockdown of interleukin 17 receptor mRNA
9 Jan 24
Aspects of the invention relate to antisense oligonucleotides directed to the interleukin 17 receptor (IL-17R), and other targets.
Richard Kang, Scott Mix, Ekambar Kandimalla
Filed: 5 May 17
Utility
Treatment of Skin Diseases and Disorders Using Inhibitors of Kallikrein-related Peptidases (KLK)
26 Oct 23
Provided herein are compositions and methods for inhibiting the expression and/or activity of kallikrein-related peptidase (KLK) (e.g., KLK5 and KLK7) genes and/or KLK (e.g., KLK5 and KLK7) gene products using oligonucleotide-based therapy.
Bart Anderson, Michael Mutolo
Filed: 6 Aug 21
Utility
Tumor Necrosis Factor Receptor Superfamily (TNFRSF) Agonists, Spherical Nucleic Acid (Sna) TLR9 Agonists and Checkpoint Inhibitors for Antitumor Therapy
19 Oct 23
Aspects of the disclosure relate to the administration of at least one of spherical nucleic acids (SNAs), a checkpoint inhibitor antibody, and an agonist of a tumor necrosis factor receptor superfamily (TNFRSF) member at various doses, schedules of administration, orders of administration, etc. for treatment of a disease, such as cancer.
Bart Anderson, Pinal Patel
Filed: 11 Aug 21
Utility
Synthesis of spherical nucleic acids using lipophilic moieties
11 Jul 23
Spherical nucleic acids (SNA) carrying self-aggregating oligonucleotides are described herein.
Richard Kang, Subbarao Nallagatla, Bart Anderson, Ekambar Kandimalla
Filed: 27 Apr 18
Utility
Administration of Spherical Nucleic Acids for Ophthalmological Uses
17 Nov 22
The present application is directed to the intravitreal use of spherical nucleic acid (SNA) molecules in the treatment of eye disorders including dry-eye, retinal edema, retinopathy, macular degeneration and glaucoma among others.
Bart Anderson, Richard Kang
Filed: 24 Apr 20
Utility
Liposomal Spherical Nucleic Acid (Sna) Constructs for Splice Modulation
3 Nov 22
Compositions related to spherical nucleic acids (SNAs) with antisense oligonucleotides and methods of treatment of diseases and disorders are disclosed therein.
Samantha M. Sarett
Filed: 3 Sep 20
Utility
Multivalent Delivery of Immune Modulators by Liposomal Spherical Nucleic Acids for Prophylactic or Therapeutic Applications
18 Aug 22
Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention.
Aleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
Filed: 18 Aug 21
Utility
Combined Spherical Nucleic Acid and Checkpoint Inhibitor for Antitumor Therapy
24 Mar 22
Aspects of the invention are directed to methods of treating cancer using a combination of spherical nucleic acids (SNAs) and a checkpoint inhibitor.
Pinal Patel, Weston Daniel, Alice Bexon, Matthias Schroff
Filed: 12 Feb 20
Utility
Spherical Nucleic Acid TLR9 Agonists
3 Mar 22
Aspects of the invention relate to compositions of spherical nucleic acids (SNAs) composed of a liposome or lipoplex complex having an oligonucleotide shell with CpG oligonucleotides positioned on the exterior of the liposome or lipoplex.
Bart Anderson, Subbarao Nallagatla, Richard Kang, Ekambar Kandimalla
Filed: 15 Apr 21
Utility
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
21 Sep 21
Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention.
Aleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
Filed: 12 Sep 19
Utility
IL-1 Beta Targeting Spherical Nucleic Acids
2 Sep 21
The invention in some aspects relates to antisense inhibitors of IL1B and related methods of use.
Bart Anderson
Filed: 20 Jun 19
Utility
Spherical Nucleic Acid-based Constructs As Immunostimulatory Agents for Prophylactic and Therapeutic Use
8 Apr 21
Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
Filed: 8 Oct 20
Utility
Liposomal Particles, Methods of Making Same and Uses Thereof
25 Feb 21
Liposomes termed as small unilamellar vesicles (SUVs), can be synthesized in the 20-50 nm size range, but encounter challenges such as instability and aggregation leading to inter-particle fusion.
Chad A. Mirkin, Sonbinh T. Nguyen, Resham Singh Banga, Natalia Chernyak, Sergei Gryaznov, Aleksandar Radovic-Moreno, Christopher Mader
Filed: 3 Sep 20
Utility
Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
19 Jan 21
Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
Filed: 25 Jul 14
Utility
Liposomal Spherical Nucleic Acid (Sna) Constructs for Survival of Motor Neuron (Sma) Inhibitors
6 Jan 21
Compositions related to spherical nucleic acids (SNAs) and structures with antisense oligonucleotides and methods of treatment of diseases and disorders are disclosed herein.
Richard Kang, Subbarao Nallagatla, Bart Anderson, Ekambar Kandimalla, Michael Mutolo
Filed: 27 Feb 19
Utility
Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
16 Nov 20
Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
Filed: 14 May 18
Utility
Nucleic Acid Nanostructures with Core Motifs
28 Oct 20
Optimized inhibitory nucleic acids are provided.
Weston Daniel, Scott Mix
Filed: 25 May 20
Utility
Anti-tnf Compounds
28 Oct 20
TNFα antisense oligonucleotides are provided herein.
Christopher C. Mader, Tiffany L. Halo, Sergei Gryaznov, Richard Kang, Weston Daniel
Filed: 15 Jul 20
Utility
Liposomal particles, methods of making same and uses thereof
5 Oct 20
Liposomes termed as small unilamellar vesicles (SUVs), can be synthesized in the 20-50 nm size range, but encounter challenges such as instability and aggregation leading to inter-particle fusion.
Chad A. Mirkin, Sonbinh T. Nguyen, Resham Singh Banga, Natalia Chernyak, Sergei Gryaznov, Aleksandar Radovic-Moreno, Christopher Mader
Filed: 7 Jan 19
Utility
Liposomal Spherical Nucleic Acid (Sna) Constructs Presenting Antisense Oligonucleotides (Aso) for Specific Knockdown of Interleukin 17 Receptor Mrna
30 Sep 20
Aspects of the invention relate to antisense oligonucleotides directed to the interleukin 17 receptor (IL-17R), and other targets.
Richard Kang
Filed: 4 May 17