28 patents
Page 2 of 2
Utility
Surface Functionalization of Liposomes and Liposomal Spherical Nucleic Acids (Snas)
23 Sep 20
The invention relates to a method of synthesizing liposomes and liposomal spherical nucleic acids with hydrophobic molecules functionalized to the surface.
Richard Kang, Sagar Anantatmula, Rishika Agarwal, Merideth Burkhart, Bart Anderson
Filed: 31 Jan 17
Utility
Anti-TNF compounds
31 Aug 20
TNFα antisense oligonucleotides are provided herein.
Christopher C. Mader, Tiffany L. Halo, Sergei Gryaznov, Richard Kang, Weston Daniel
Filed: 15 Jan 19
Utility
CorrectedSpherical Nucleic Acid TLR9 Agonists
12 Aug 20
Aspects of the invention relate to compositions of spherical nucleic acids (SNAs) composed of a liposome or lipoplex complex having an oligonucleotide shell with CpG oligonucleotides positioned on the exterior of the liposome or lipoplex.
Bart Anderson, Subbarao Nallagatla, Richard Kang, Ekambar Kandimalla
Filed: 4 May 17
Utility
Nucleic acid nanostructures with core motifs
6 Jul 20
Optimized inhibitory nucleic acids are provided.
Weston Daniel, Scott Mix
Filed: 13 Jan 16
Utility
Synthesis of Spherical Nucleic Acids Using Lipophilic Moieties
17 Jun 20
Spherical nucleic acids (SNA) carrying self-aggregating oligonucleotides are described herein.
Richard Kang, Subbarao Nallagatla, Bart Anderson, Ekambar Kandimalla
Filed: 26 Apr 18
Utility
Multivalent Delivery of Immune Modulators by Liposomal Spherical Nucleic Acids for Prophylactic or Therapeutic Applications
4 Mar 20
Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention.
Aleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
Filed: 11 Sep 19
Utility
Liposomal Particles, Methods of Making Same and Uses Thereof
22 Jan 20
Liposomes termed as small unilamellar vesicles (SUVs), can be synthesized in the 20-50 nm size range, but encounter challenges such as instability and aggregation leading to inter-particle fusion.
Chad A. Mirkin, Sonbinh T. Nguyen, Resham Singh Banga, Natalia Chernyak, Sergei Gryaznov, Aleksandar Radovic-Moreno, Christopher Mader
Filed: 7 Jan 19
Utility
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
7 Oct 19
Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention.
Aleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
Filed: 3 Jun 15