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FREQ Frequency Therapeutics

GRANT
Utility
Thermoreversible compositions for administration of therapeutic agents
2 Nov 21
The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
Filed: 4 Jan 19
GRANT
Utility
Compositions and methods for generating hair cells by upregulating JAG-1
2 Nov 21
Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
Christopher Loose, Will McLean, Megan Harrison
Filed: 19 Aug 19
APP
Utility
1H-PYRROLE-2,5-DIONE Compounds and Methods of Using Them to Induce Self-renewal of Stem/progenitor Supporting Cells
30 Sep 21
The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN
Filed: 3 Jun 21
APP
Utility
Solubilized Compositions for Controlled Proliferation of Stem Cells / Generating Inner Ear Hair Cells Using GSK3 Inhibitors: I
26 Aug 21
The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Christopher LOOSE, Will MCLEAN, Megan S. HARRISON, Michael R. JIROUSEK
Filed: 12 May 21
GRANT
Utility
1H-pyrrole-2,5-dione compounds and methods of using same
20 Jul 21
The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Christopher Loose, Bradley Tait, Rajesh Manchanda, Will Mclean
Filed: 21 Dec 17
GRANT
Utility
Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: I
15 Jun 21
The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
Filed: 20 Dec 18
APP
Utility
Methods for Controlled Proliferation of Stem Cells / Generating Inner Ear Hair Cells Using 2-PYRIMIDINYLAMINOETHYLAMINO-2-PYRIDYL Based Compounds
1 Apr 21
Christopher LOOSE, Will MCLEAN, Melissa HILL-DRZEWI
Filed: 12 May 20
APP
Utility
1,2-DIHYDRO-3H-PYRAZOL-3-ONE Compounds and Methods of Using Same
7 Oct 20
The present disclosure relates to 1,2-dihydro-3H-pyrazol-3-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN
Filed: 20 Dec 18
APP
Utility
Methods for Hair Follicle Stem Cell Proliferation
22 Apr 20
The present invention relates to compositions of minoxidil and Sonic Hedgehog (Shh) pathway activators and optionally, Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.
Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN, Megan HARRISON, Sara STRECKER
Filed: 16 Oct 19
APP
Utility
Methods for Hair Follicle Stem Cell Proliferation
15 Apr 20
The present invention relates to compositions of Sonic Hedgehog (Shh) pathway activators and Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.
Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN, Megan S. HARRISON, Sara STRECKER
Filed: 10 Apr 18
APP
Utility
Compositions and Methods for Generating Hair Cells by Downregulating Foxo
11 Mar 20
Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
Christopher LOOSE, Will MCLEAN, Megan HARRISON, Melissa HILL-DRZEWI
Filed: 18 Aug 19
APP
Utility
Compositions and Methods for Generating Hair Cells by Upregulating JAG-1
11 Mar 20
Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
Christopher Loose, Will McLean, Megan Harrison
Filed: 18 Aug 19
APP
Utility
Compositions and Methods for Generating Hair Cells by Upregulating PI3K
11 Mar 20
Provided are compositions and methods comprising PI3K agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
Christopher LOOSE, Will MCLEAN, Megan HARRISON
Filed: 18 Aug 19
APP
Utility
1H-PYRROLE-2,5-DIONE Compounds and Methods of Using Them to Induce Self-renewal of Stem/progenitor Supporting Cells
20 Nov 19
The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN
Filed: 20 Dec 17
APP
Utility
Compositions and Methods for Increasing Remyelination
6 Nov 19
Provided are compositions and methods comprising a MAChR antagonist/inverse agonist/partial agonist and a histamine H3 receptor antagonist/inverse agonist/partial agonist for increasing proliferation Oligodendrocyte Progenitor Cells (OPCs) into mature, myelinating oligodendrocytes, and related methods of treating demyelination disorders.
Bradley TAIT, Michael R. JIROUSEK, Christopher LOOSE, William W. CHIN
Filed: 4 Apr 19
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