9 patents
Utility
Methods of delivering transgenes to the eye
9 Jan 24
Provided herein are methods of delivering transgenes to an eye of a subject comprising the use of pharmaceutical compositions having one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of the transgene in the eye.
Suma Krishnan
Filed: 30 Nov 22
Utility
Viral vectors for cancer therapy
10 Oct 23
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding an immunomodulatory polypeptide (e.g., a pro-inflammatory cytokine such as a human IL-2 or IL-12 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of cancer, such as lung cancer); and articles of manufacture or kits thereof.
Suma Krishnan, Trevor Parry, Dana Michelle Previte, Mary Jane Duermeyer
Filed: 1 Apr 22
Utility
Compositions and methods for the treatment of autosomal recessive congenital ichthyosis
8 Aug 23
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a transglutaminase (TGM) polypeptide (e.g., a Transglutaminase-1 (TGM1) polypeptide); viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.
Suma Krishnan, Pooja Agarwal, John C. Freedman, Mark E. O'Malley, Lauren K. Regula
Filed: 3 Jan 20
Utility
Compositions and methods for the treatment of Netherton Syndrome
9 May 23
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a Serine Protease Inhibitor Kazal-type (SPINK) polypeptide (e.g., a SPINK5 polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of Netherton Syndrome); and articles of manufacture or kits thereof.
Pooja Agarwal, Suma Krishnan, John C. Freedman
Filed: 22 Jul 22
Utility
Compositions and methods for the treatment of wounds, disorders, and diseases of the skin
30 Nov 21
The present disclosure relates, in part, to pharmaceutical compositions comprising one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of Collagen alpha-1 (VII) chain polypeptide and/or Lysyl hydroxylase 3 polypeptide and/or Keratin type I cytoskeletal 17 polypeptide in a subject.
Suma Krishnan, Pooja Agarwal
Filed: 10 Oct 19
Utility
Compositions and methods for delivering CFTR polypeptides
9 Nov 20
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide (e.g., a human CFTR polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of a chronic lung disease, such as cystic fibrosis); and articles of manufacture or kits thereof.
Trevor Parry, Suma Krishnan, Pooja Agarwal
Filed: 6 Feb 20
Utility
Recombinant nucleic acids encoding cosmetic protein(s) for aesthetic applications
28 Sep 20
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding one or more cosmetic proteins (e.g., one or more human collagen proteins); viruses comprising the recombinant nucleic acids; compositions (e.g., cosmetic formulations) comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.
Suma Krishnan, Trevor Parry, Pooja Agarwal
Filed: 25 Apr 19
Utility
Compositions and methods for the treatment of autosomal recessive congenital ichthyosis
6 Jan 20
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a transglutaminase (TGM) polypeptide (e.g., a Transglutaminase-1 (TGM1) polypeptide); viruses comprising the recombinant nucleic acids; compositions comprising the recombinant nucleic acids and/or viruses; methods of their use; and articles of manufacture or kits thereof.
Suma Krishnan, Pooja Agarwal, John C. Freedman, Mark E. O'Malley, Lauren K. Regula
Filed: 10 Apr 19
Utility
Compositions and methods for the treatment of wounds, disorders, and diseases of the skin
14 Oct 19
The present disclosure relates, in part, to pharmaceutical compositions comprising one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of Collagen alpha-1 (VII) chain polypeptide and/or Lysyl hydroxylase 3 polypeptide and/or Keratin type I cytoskeletal 17 polypeptide in a subject.
Suma Krishnan, Pooja Agarwal
Filed: 30 Oct 18
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