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AKUS Akouos

APP
Utility
a Method for Treating an Auditory Neuropathy Spectrum Disorder
6 Jan 22
The present invention provides a method for treating an auditory neuropathy spectrum disorder in a subject comprising transferring the gene of DFNB59 via an adeno-associated virus (AAV) vector to the subject.
Yen-Fu Cheng, Chen-Chi Wu, Ying-Chang Lu
Filed: 27 Sep 19
APP
Utility
Aav-mediated Delivery of Therapeutic Antibodies to the Inner Ear
25 Nov 21
Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
Emmanuel John Simons, Robert Ng, Michael McKenna
Filed: 3 Aug 21
APP
Utility
Compositions and Methods for Treating Non-age-associated Hearing Impairment In a Human Subject
25 Nov 21
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
Filed: 16 Jul 21
APP
Utility
Methods of Treating Non-syndromic Sensorineural Hearing Loss
28 Oct 21
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of a stereocilin protein, and the use of these compositions to treat non-syndromic sensorineural hearing loss in a subject.
Emmanuel John Simons, Robert Ng
Filed: 12 Jul 19
APP
Utility
Methods of Treating CLRN1-ASSOCIATED Hearing Loss And/or Vision Loss
9 Sep 21
Provided herein are compositions that include a single nucleic acid vector or two different nucleic acid vectors, and the use of these compositions to treat hearing loss and/or vision loss in a subject.
Emmanuel John Simons, Robert Ng
Filed: 25 Jun 19
APP
Utility
Aav-mediated Delivery of Therapeutic Antibodies to the Inner Ear
11 Mar 21
Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
Emmanuel John Simons, Robert Ng, Michael McKenna
Filed: 19 Dec 18
APP
Utility
Compositions and Methods for Treating Non-age-associated Hearing Impairment In a Human Subject
16 Dec 20
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Robert Ng, Ellen Reisinger, Hanan Al-Moyed, Sebastian Kügler
Filed: 21 Feb 19
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