4 patents
Utility
Compositions and methods for treating non-age-associated hearing impairment in a human subject
7 Nov 23
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Robert Ng
Filed: 29 Jul 22
Utility
Compositions and methods for treating non-age-associated hearing impairment in a human subject
10 Oct 23
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
Filed: 2 Sep 22
Utility
AAV-mediated delivery of therapeutic antibodies to the inner ear
11 Jul 23
Provided herein are methods that include introducing into an inner ear of a mammal a therapeutically effective amount of an adeno-associated virus (AAV) vector that includes a nucleotide sequence encoding (a) a polypeptide including an antibody heavy chain variable domain operably linked to a signal peptide and a polypeptide including an antibody light chain variable domain operably linked to a signal peptide; (b) a polypeptide including an antigen-binding antibody fragment operably linked to a signal peptide; or (c) a soluble vascular endothelial growth factor receptor operably linked to a signal peptide.
Emmanuel John Simons, Robert Ng, Michael McKenna
Filed: 3 Aug 21
Utility
Compositions and methods for treating non-age-associated hearing impairment in a human subject
13 Dec 22
Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Emmanuel John Simons, Ellen Reisinger, Sebastian Kügler, Hanan Al-Moyed
Filed: 16 Jul 21
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