32 patents
Utility
Regulatory T cell epitopes, compositions and uses thereof
19 Dec 23
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region.
Anne De Groot, William Martin, Daniel S. Rivera
Filed: 21 Apr 21
Utility
Regulatory T Cell Epitopes
12 Oct 23
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprise a polypeptide comprising at least a portion of SEQ NOS: 1-73, fragments and/or variants thereof, as well as methods of producing and using the same.
Anne De Groot, William Martin
Filed: 13 Aug 21
Utility
Regulatory T Cell Epitopes
7 Sep 23
This disclosure provides compositions including regulatory T-cell epitopes that includes a polypeptide including one or more of SEQ ID NOs. 1, 8, 117, 118, 119, and combinations thereof, and fragments and/or variants thereof, as well as methods of using the same.
Anne De Groot, William Martin
Filed: 12 Dec 22
Utility
Regulatory T Cell Epitopes and Detolerized SARS-COV-2 Antigens
3 Aug 23
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprises a polypeptide comprising at least a portion of SEQ ID NOS: 4-370, 391-440, and 448-833 (and/or fragments and variants thereof), and optionally 1 to 12 additional amino acids distributed in any ratio on the N-terminus and/or C-terminus of the polypeptide of SEQ ID NOS: 4-370, 391-440, and 448-833, as well as methods of producing and using the same.
Anne De Groot, William Martin
Filed: 12 Feb 21
Utility
Regulatory T Cell Epitopes
6 Jul 23
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprise a polypeptide comprising at least a portion of SEQ NOS: 1-14, fragments and/or variants thereof, as well as methods of producing and using the same.
William Martin, Amy S. Rosenberg
Filed: 23 Aug 22
Utility
Unknown
4 Jul 23
Compositions and methods for inducing a protective immune response against Coxiella burnetii, to reduce a subject's risk of developing Q fever.
Mark C. Poznansky, Ann Elizabeth Sluder, Timothy Alan Brauns, Anne Searls De Groot, Leonard Jeffrey Moise, Anja Garritsen, Anja Scholzen
Filed: 25 Mar 19
Utility
Tregitope Constructs Useful In the Prevention and Treatment of Type 1 Diabetes
25 May 23
The present disclosure generally relates to novel Tregitope-blood component conjugates and modified polypeptides comprising Tregitopes, with said modified peptides being capable of reacting with blood components to form such Tregitope-blood component conjugates.
Anne De Groot, William Martin
Filed: 26 Mar 21
Utility
T Cell Epitope Clusters and Related Compositions Useful In the Prevention, Diagnosis, and Treatment of COVID-19
18 May 23
The present disclosure relates to novel epitope-based compositions, including vaccines, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diseases caused by SARS-CoV-2, including the highly contagious coronavirus disease 2019.
Anne De Groot, William Martin
Filed: 12 Feb 21
Utility
Modified INTERFERON-ALPHA-2 Having Reduced Immunogenicity
27 Apr 23
The present disclosure is directed to compositions comprising modified interferon-α2 polypeptides having interferon-α2 activity and reduced immunogenicity.
Eduardo Federico Mufarrege, Sofía Inés Giorgetti, Marina Etcheverrigaray, Anne Searls De Groot, William D. Martin
Filed: 16 Dec 20
Utility
Regulatory T cell epitopes
13 Sep 22
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprise a polypeptide comprising at least a portion of SEQ NOS: 1-14, fragments and/or variants thereof, as well as methods of producing and using the same.
William Martin, Amy S. Rosenberg
Filed: 5 Oct 18
Utility
Compositions Useful in Both Homologous And Heterologous Vaccine Regimens
27 Jan 22
The invention provides a swine influenza vaccine composition as part of a vaccine package where the composition produces one or more T cell epitopes that are highly conserved in circulating influenza strains including those of H1N1 and others.
Anne De Groot, Leonard J. Moise, William Martin
Filed: 23 Jun 21
Utility
Peptides for Inducing Heterosubtypic Influenza T Cell Responses
9 Dec 21
The present invention provides compositions and methods for generation of an anti-influenza immune response.
Daniel F. HOFT, Christopher S. EICKHOFF, Annie DE GROOT
Filed: 25 Oct 19
Utility
Regulatory T Cell Epitopes
7 Oct 21
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprises a polypeptide comprising at least a portion of SEQ NOS: 1-124 (and/or fragments and variants thereof), and optionally 1 to 12 additional amino acids distributed in any ratio on the N-terminus and/or C-terminus of the polypeptide of SEQ ID NOS: 1-124, as well as methods of producing and using the same.
Anne De Groot, William Martin
Filed: 26 Mar 21
Utility
Regulatory T Cell Epitopes
30 Sep 21
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprise a polypeptide comprising at least a portion of SEQ NOS: 1-14 and 74-116, fragments and/or variants thereof, as well as methods of producing and using the same.
Anne De Groot, William Martin
Filed: 26 Mar 21
Utility
Regulatory T Cell Epitopes, Compositions and Uses Thereof
19 Aug 21
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region.
Anne De Groot, William Martin, Daniel S. Rivera
Filed: 21 Apr 21
Utility
Regulatory T Cell Epitopes, Compositions and Uses Thereof
5 Aug 21
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region.
Anne De Groot, William Martin, Daniel S. Rivera
Filed: 21 Apr 21
Utility
Regulatory T cell epitopes, compositions and uses thereof
29 Jun 21
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region.
Anne De Groot, William Martin, Daniel S. Rivera
Filed: 16 Oct 18
Utility
Regulatory T cell epitopes, compositions and uses thereof
29 Jun 21
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region.
Anne De Groot, William Martin, Daniel S. Rivera
Filed: 22 Jun 18
Utility
Regulatory T cell epitopes, compositions and uses thereof
29 Jun 21
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region.
Anne De Groot, William Martin, Daniel S. Rivera
Filed: 22 Jun 18
Utility
Regulatory T cell epitopes, compositions and uses thereof
29 Jun 21
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region.
Anne De Groot, William Martin, Daniel S. Rivera
Filed: 22 Jun 18