18 patents
Utility
Regulatory T Cell Epitopes
12 Oct 23
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprise a polypeptide comprising at least a portion of SEQ NOS: 1-73, fragments and/or variants thereof, as well as methods of producing and using the same.
Anne De Groot, William Martin
Filed: 13 Aug 21
Utility
Regulatory T Cell Epitopes
7 Sep 23
This disclosure provides compositions including regulatory T-cell epitopes that includes a polypeptide including one or more of SEQ ID NOs. 1, 8, 117, 118, 119, and combinations thereof, and fragments and/or variants thereof, as well as methods of using the same.
Anne De Groot, William Martin
Filed: 12 Dec 22
Utility
Regulatory T Cell Epitopes and Detolerized SARS-COV-2 Antigens
3 Aug 23
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprises a polypeptide comprising at least a portion of SEQ ID NOS: 4-370, 391-440, and 448-833 (and/or fragments and variants thereof), and optionally 1 to 12 additional amino acids distributed in any ratio on the N-terminus and/or C-terminus of the polypeptide of SEQ ID NOS: 4-370, 391-440, and 448-833, as well as methods of producing and using the same.
Anne De Groot, William Martin
Filed: 12 Feb 21
Utility
Regulatory T Cell Epitopes
6 Jul 23
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprise a polypeptide comprising at least a portion of SEQ NOS: 1-14, fragments and/or variants thereof, as well as methods of producing and using the same.
William Martin, Amy S. Rosenberg
Filed: 23 Aug 22
Utility
Tregitope Constructs Useful In the Prevention and Treatment of Type 1 Diabetes
25 May 23
The present disclosure generally relates to novel Tregitope-blood component conjugates and modified polypeptides comprising Tregitopes, with said modified peptides being capable of reacting with blood components to form such Tregitope-blood component conjugates.
Anne De Groot, William Martin
Filed: 26 Mar 21
Utility
T Cell Epitope Clusters and Related Compositions Useful In the Prevention, Diagnosis, and Treatment of COVID-19
18 May 23
The present disclosure relates to novel epitope-based compositions, including vaccines, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diseases caused by SARS-CoV-2, including the highly contagious coronavirus disease 2019.
Anne De Groot, William Martin
Filed: 12 Feb 21
Utility
Modified INTERFERON-ALPHA-2 Having Reduced Immunogenicity
27 Apr 23
The present disclosure is directed to compositions comprising modified interferon-α2 polypeptides having interferon-α2 activity and reduced immunogenicity.
Eduardo Federico Mufarrege, Sofía Inés Giorgetti, Marina Etcheverrigaray, Anne Searls De Groot, William D. Martin
Filed: 16 Dec 20
Utility
Compositions Useful in Both Homologous And Heterologous Vaccine Regimens
27 Jan 22
The invention provides a swine influenza vaccine composition as part of a vaccine package where the composition produces one or more T cell epitopes that are highly conserved in circulating influenza strains including those of H1N1 and others.
Anne De Groot, Leonard J. Moise, William Martin
Filed: 23 Jun 21
Utility
Peptides for Inducing Heterosubtypic Influenza T Cell Responses
9 Dec 21
The present invention provides compositions and methods for generation of an anti-influenza immune response.
Daniel F. HOFT, Christopher S. EICKHOFF, Annie DE GROOT
Filed: 25 Oct 19
Utility
Regulatory T Cell Epitopes
7 Oct 21
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprises a polypeptide comprising at least a portion of SEQ NOS: 1-124 (and/or fragments and variants thereof), and optionally 1 to 12 additional amino acids distributed in any ratio on the N-terminus and/or C-terminus of the polypeptide of SEQ ID NOS: 1-124, as well as methods of producing and using the same.
Anne De Groot, William Martin
Filed: 26 Mar 21
Utility
Regulatory T Cell Epitopes
30 Sep 21
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprise a polypeptide comprising at least a portion of SEQ NOS: 1-14 and 74-116, fragments and/or variants thereof, as well as methods of producing and using the same.
Anne De Groot, William Martin
Filed: 26 Mar 21
Utility
Regulatory T Cell Epitopes, Compositions and Uses Thereof
19 Aug 21
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region.
Anne De Groot, William Martin, Daniel S. Rivera
Filed: 21 Apr 21
Utility
Regulatory T Cell Epitopes, Compositions and Uses Thereof
5 Aug 21
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region.
Anne De Groot, William Martin, Daniel S. Rivera
Filed: 21 Apr 21
Utility
Neo-epitope Vaccines and Methods of Treating Cancer
27 May 21
The invention relates to improved strategies, compositions, and methods for producing neoplasia vaccines and for their use in methods of treating cancer in a patient.
William D. Martin, Anne S. De Groot, Gad Berdugo, Guilhem Richard, Dominique Bridon, Leonard Moise, Michael F. Princiotta
Filed: 18 Nov 20
Utility
Compositions and Methods for Shared Neo-epitope Vaccines
20 May 21
The present invention relates to improved strategies, compositions, and methods for producing shared neoplasia vaccines, including “off the shelf” pre-furnished shared neo-epitope warehouses, which can be used to enable the rapid production of bladder cancer neoantigen-based vaccines.
William D. Martin, Anne S. De Groot, Gad Berdugo, Guilhem Richard, Dominique Bridon, Leonard Moise, Michael F. Princiotta
Filed: 18 Nov 20
Utility
Coxiella Burnetii Epitopes for T Cell-targeted Q Fever Vaccines
22 Apr 21
Compositions and methods for inducing a protective immune response against Coxiella burnetii, to reduce a subject's risk of developing Q fever
Mark C. Poznansky, Ann Elizabeth Sluder, Timothy Alan Brauns, Anne Searls De Groot, Leonard Jeffrey Moise, Anja Garritsen, Anja Scholzen
Filed: 25 Mar 19
Utility
Regulatory T Cell Epitopes
30 Sep 20
The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprise a polypeptide comprising at least a portion of SEQ NOS: 1-14, fragments and/or variants thereof, as well as methods of producing and using the same.
William Martin, Amy S. Rosenberg
Filed: 4 Oct 18
Utility
Regulatory T Cell Epitopes, Compositions and Uses Thereof
20 Nov 19
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region.
Anne De Groot, William Martin, Daniel S. Rivera
Filed: 1 Aug 19
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