28 patents
Page 2 of 2
Utility
Anti-talen Antibodies and Uses Thereof
16 Dec 20
The present disclosure provides, among other things, antibodies for detecting TALENs and/or FokI nucleases in a sample and methods of using the same.
Thomas Charles PERTEL, Barbra Johnson SASU
Filed: 11 Jun 20
Utility
Rituximab-resistant Chimeric Antigen Receptors and Uses Thereof
9 Dec 20
Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD19 antigen binding domain that specifically binds to CD19 and is resistant to rituximab binding; and immune cells comprising these CD19-specific CARs, e.g., CAR-T cells.
Thomas Charles PERTEL, Barbra Johnson SASU, Mark W. LEONARD
Filed: 23 Apr 20
Utility
Methods of Manufacturing Allogeneic Car T Cells
28 Oct 20
Described herein are improved media for culturing immune cells, and methods of use thereof.
Diego A. VARGAS-INCHAUSTEGUI, Thomas Charles PERTEL, Barbra Johnson SASU
Filed: 23 Apr 20
Utility
Antibodies Against 4G7-DERIVED Chimeric Antigen Receptors
21 Oct 20
Provided herein are isolated antibodies that specifically bind anti-CD19 chimeric antigen receptors (CARs) derived from a 4G7 scFv.
Thomas Charles PERTEL, Barbra Johnson SASU, Tao SAI
Filed: 16 Apr 20
Utility
METHODS FOR ENHANCING TCRab+ CELL DEPLETION
7 Oct 20
Provided herein are improved methods for robust TCR+ cell depletion and production of populations of TCR− cells, which can be beneficial to minimize the GvHD risk in patients receiving allogeneic CAR T cell therapy.
Yajin NI, Hongxiu NING, Janet M. LEE, Mark W. LEONARD
Filed: 19 Mar 20
Utility
Constitutively Active Chimeric Cytokine Receptors
16 Sep 20
Provided herein are constitutively active chimeric cytokine receptors (CACCRs).
Regina Junhui LIN, Thomas John VAN BLARCOM, Siler PANOWSKI, Barbra Johnson SASU
Filed: 27 Feb 20
Utility
Chimeric Cytokine Receptors Bearing a PD-1 Ectodomain
2 Sep 20
Provided herein are PD-1 chimeric cytokine receptors.
Regina Junhui LIN, Thomas John VAN BLARCOM, Siler PANOWSKI, Barbra Johnson SASU
Filed: 27 Feb 20
Utility
Chimeric Antigen Receptors Targeting B-cell Maturation Antigen and Methods of Use Thereof
19 Aug 20
Provided herein are BCMA CARs and CAR-T cells, methods of making, and using the same.
David Chang, Arun Balakumaran, Cyril Alkis Konto
Filed: 25 Nov 19