5 patents
Utility
Chimeric cytokine receptors bearing a PD-1 ectodomain
17 Oct 23
Provided herein are PD-1 chimeric cytokine receptors.
Regina Junhui Lin, Thomas John Van Blarcom, Siler Panowski, Barbra Johnson Sasu
Filed: 28 Feb 20
Utility
Anti-TALEN antibodies and uses thereof
10 Oct 23
The present disclosure provides, among other things, antibodies for detecting TALENs and/or FokI nucleases in a sample and methods of using the same.
Thomas Charles Pertel, Barbra Johnson Sasu
Filed: 12 Jun 20
Utility
Antibodies against 4G7-derived chimeric antigen receptors
22 Aug 23
Provided herein are isolated antibodies that specifically bind anti-CD19 chimeric antigen receptors (CARs) derived from a 4G7 scFv.
Thomas Charles Pertel, Barbra Johnson Sasu, Tao Sai
Filed: 17 Apr 20
Utility
Modified caspase-9 polypeptides and methods of use thereof
10 May 22
Provided herein are modified caspase-9 polypeptides, and chimeric caspase-9 proteins containing the modified caspase-9 polypeptides.
Meritxell Galindo Casas, Thomas John Van Blarcom
Filed: 31 Oct 18
Utility
Inhibitory chimeric antigen receptors
27 Jul 21
The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprising an extracellular domain comprising an antigen binding domain, a transmembrane domain, and, an intracellular domain wherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein said ITSM is a sequence of amino acid TX1YX2X3X4, wherein X1 is an amino acid X2 is an amino acid X3 is an amino acid and X4 is V or I.
Arvind Rajpal, Shobha Chowdary Potluri, Laurent Poirot, Alexandre Juillerat, Thomas Charles Pertel, Donna Marie Stone, Barbra Johnson Sasu
Filed: 9 Nov 15
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