3 patents
Utility
Oncolytic virus strain
18 Oct 22
The present invention relates to an oncolytic virus which is, or is derived from, a clinical isolate which has been selected by comparing the abilities of a panel of three or more clinical isolates of the same viral species to kill tumor cells of two or more tumor cell lines in vitro and selecting a clinical isolate which is capable of killing cells of two or more tumor cell lines more rapidly and/or at a lower dose in vitro than one or more of the other clinical isolates in the panel.
Robert S. Coffin
Filed: 10 Jan 20
Utility
Modified oncolytic virus
30 Aug 22
The present invention relates to an oncolytic virus comprising: (i) a fusogenic protein-encoding gene; and (ii) an immune stimulatory molecule-encoding gene.
Robert S. Coffin
Filed: 24 Feb 20
Utility
Engineered virus
16 Mar 21
The present invention relates to oncolytic virus comprising: (i) a GM-CSF-encoding gene; and (ii) an immune co-stimulatory pathway activating molecule or an immune co-stimulatory pathway activating molecule-encoding gene.
Robert Coffin
Filed: 9 Jan 17
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