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BBIO BridgeBio Pharma

APP
Utility
Substituted Heterocyclic Inhibitors of PTPN11
14 Oct 21
The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases.
Philip JONES, Jason CROSS, Jason BURKE, Timothy MCAFOOS, Zhijun KANG
Filed: 3 Feb 21
APP
Utility
Adeno-associated Virus Gene Therapy for 21-HYDROXYLASE Deficiency
9 Sep 21
Disclosed herein are recombinant adeno-associated viral vectors expressing 21-hydroxylase (21OH) protein and related uses for treating 21OH deficiency.
Pierre Bougneres, Guangping Gao
Filed: 17 Jan 19
GRANT
Utility
PTPN11 inhibitors
31 Aug 21
The present invention relates to compounds which are useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases.
Philip Jones, Barbara Czako, Christopher L. Carroll, Pijus Mandal, Jason Cross
Filed: 9 Aug 19
GRANT
Utility
Compounds and methods of use
24 Aug 21
This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.
Chun Jiang, Ruihong Chen, Anjali Pandey, Biswajit Kalita, Athisayamani Jeyaraj Duraiswamy
Filed: 27 Feb 19
GRANT
Utility
Compounds and methods of use
22 Jun 21
This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.
Chun Jiang, Anjali Pandey, Ruihong Chen, Biswajit Kalita, Athisayamani Jeyaraj Duraiswamy
Filed: 27 Feb 20
APP
Utility
Glycolate Oxidase Inhibitors and Use Thereof
10 Jun 21
The present invention provides pyrazoles, isoxazoles, isothiazoles, thiadiazoles, and pyridazines according to Formula I as described herein, and pharmaceutically acceptable salts thereof.
Hans MAAG, Miguel Xavier Fernandes
Filed: 28 Dec 18
APP
Utility
Collagen IV Binding Assay for the Detection of Collagen VII
6 May 21
The invention features a method of detecting and/or quantifying collagen VII or a fragment thereof in a sample, by contacting the sample with collagen IV which binds to collagen VII; and detecting binding of collagen IV with collagen VII.
Sheila G. Magil
Filed: 5 Jan 21
APP
Utility
Benzoxazinone Compounds As KLK5/7 Dual Inhibitors
8 Apr 21
Andreas BETZ, Robert ZAMBONI
Filed: 30 Sep 20
GRANT
Utility
Substituted heterocyclic inhibitors of PTPN11
23 Mar 21
The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases.
Philip Jones, Jason Cross, Jason Burke, Timothy Mcafoos, Zhijun Kang
Filed: 1 May 19
APP
Utility
Small Molecule Modulators of Pantothenate Kinases
4 Mar 21
The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment.
Richard E. LEE, Rajendra P. TANGALLAPALLY, Charles O. ROCK, Suzanne JACKOWSKI, Anne V. EDWARDS, Mi Kyung YUN, Chitra SUBRAMANIAN, Robert ZAMBONI, T. Jagadeeswar REDDY
Filed: 26 Dec 18
GRANT
Utility
Collagen IV binding assay for the detection of collagen VII
16 Feb 21
The present disclosure features a method of detecting and/or quantifying collagen VII or a fragment thereof in a sample, the method including contacting the sample with collagen IV or a fragment thereof which binds to collagen VII; and contacting the sample with an anti-collagen VII antibody, wherein the anti-collagen VII antibody binds to the NC2 domain of collagen VII; detecting binding of the anti-collagen VII antibody to thereby detect and/or quantify an amount of collagen VII or the fragment thereof in the sample.
Sheila G. Magil
Filed: 11 Jul 17
APP
Utility
Methods of Treating Disorders Associated with Castor
28 Jan 21
The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels.
Suzanne JACKOWSKI, Charles O. ROCK, Richard E. LEE, Lalit Kumar SHARMA, Mi Kyung YUN, Chitra SUBRAMANIAN, Rajendra P. TANGALLAPALLY, Anne V. EDWARDS, Robert ZAMBONI, T. Jagadeeswar REDDY, Jiuyu LIU
Filed: 26 Dec 18
GRANT
Utility
Therapeutic regimens and methods for improving visual function in visual disorders associated with an endogenous retinoid deficiency
9 Nov 20
Disclosed herein are therapeutic regimens for improving visual function in Retinitis Pigmentosa and other visual disorders associated with an endogenous retinoid deficiency in a subject by administering a therapeutically effective amount of a synthetic retinal derivative, for example a 9- or 11-cis retinyl ester, according to the therapeutic regimen which leads to local recovery of visual functions such as visual fields, visual acuity and retinal sensitivity, among others.
Suzanne Cadden
Filed: 10 Jun 18
APP
Utility
Collagen 7 Compositions and Methods of Using the Same
7 Oct 20
The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.
Igor Quinones-Garcia, Lin Guey, Kris Lowe, Vinh Nguyen, Bing He, Amey Bandekar, Sujit Basu
Filed: 14 May 20
APP
Utility
Compounds and Methods of Use
23 Sep 20
This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.
Chun Jiang, Anjali Pandey, Ruihong Chen, Biswajit Kalita, Athisayamani Jeyaraj Duraiswamy
Filed: 26 Feb 20
GRANT
Utility
Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle
10 Aug 20
Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle are described as retinoid replacement therapies for treating retinal degenerations in humans.
Ronald Erwin Boch
Filed: 11 Oct 18
APP
Utility
Topical Phosphoinositide 3-KINASE Inhibitors
5 Aug 20
Ahmed F. ABDEL-MAGID, Agis KYDONIEUS, Thomas ROSSI, Hock S. Tan
Filed: 4 Feb 20
GRANT
Utility
Collagen 7 compositions and methods of using the same
29 Jun 20
The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.
Igor Quinones-Garcia, Lin Guey, Kris Lowe, Vinh Nguyen, Bing He, Amey Bandekar, Sujit Basu
Filed: 20 Dec 16
GRANT
Utility
Methods of purifying collagen 7
1 Jun 20
The present disclosure provides methods for capturing recombinant collagen 7 from cell culture and methods of purifying recombinant collagen 7.
Igor Quinones-Garcia, Benjamin Simeone, Raymond Lillie, Ting Yang, David Nichols
Filed: 9 Mar 17
APP
Utility
Methods of Cancer Treatment
6 May 20
The present disclosure relates to a method of treating a subject with cancer with a ferroptosis inducer, including use of the ferroptosis inducer in combination with a second therapeutic agent.
Ruihong Chen, Chun Jiang
Filed: 23 May 18
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