5 patents
Utility
Uses of adenosine base editors
24 Oct 23
The disclosure provides methods and compositions for treating blood diseases/disorders, such as sickle cell disease, hemochromatosis, hemophilia, and beta-thalassemia.
David R. Liu, Nicole Marie Gaudelli, Michael S. Packer, Gregory Newby
Filed: 16 Oct 18
Utility
Compositions and methods for treating hemoglobinopathies
12 Sep 23
The present invention features compositions and methods for editing deleterious mutations associated with hemoglobinopathies, such as sickle cell disease (SCD).
Ian Slaymaker, Nicole Gaudelli, Yi Yu, Bernd Zetsche, David A. Born, Seung-Joo Lee, Michael Packer
Filed: 13 Apr 22
Utility
Compositions and methods for treating hemoglobinopathies
31 May 22
The present invention features compositions and methods for editing deleterious mutations associated with hemoglobinopathies, such as sickle cell disease (SCD).
Ian Slaymaker, Nicole Gaudelli, Yi Yu, Bernd Zetsche, David A. Born, Seung-Joo Lee, Michael Packer
Filed: 26 Mar 21
Utility
Adenosine deaminase base editors and methods of using same to modify a nucleobase in a target sequence
26 Oct 21
The disclosure provides compositions comprising novel adenosine base editors (e.g., ABE8) that have increased efficiency and methods of using these adenosine deaminase variants for editing a target sequence.
Nicole Gaudelli, Michael Packer, Ian Slaymaker, Yi Yu, Bernd Zetsche, Jason Michael Gehrke, Natalie Petrossian, Angelica Messana, Yvonne Aratyn, Francine Gregoire, Genesis Lung, Shaunna Berkovitch, David A. Born, Seung-Joo Lee
Filed: 18 Dec 20
Utility
Compositions and methods for treating hemoglobinopathies
12 Oct 21
The present invention features compositions and methods for editing deleterious mutations associated with hemoglobinopathies, such as sickle cell disease (SCD).
Ian Slaymaker, Nicole Gaudelli, Yi Yu, Bernd Zetsche, David A. Born, Seung-Joo Lee, Michael Packer
Filed: 26 Mar 21
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