Placental Derived Natural Killer Cells for Treatment of Coronavirus Infections
6 Jan 22
Provided herein are methods of using populations of natural killer (NK) cells and/or ILC3 cells derived from a population of hematopoietic stem or progenitor cells in methods for treating a viral infection, e.g., a coronavirus infection.
Lin KANG, William VAN DER TOUW, Vanesssa VOSKINARIAN-BERSE, Xuan GUO, Robert J. HARIRI, Xiaokui ZHANG, Catherine BALINT, Nassir HABBOUBI, Stacy HERB, Sharmila KOPPISETTI, Tanel MAHLAKOIV, Bhavani STOUT, Junhong ZHU, Corey CASPER, Shuyang HE
Filed: 29 Jan 21
Methods of treating acute myeloid leukemia and multiple myeloma using natural killer cells
23 Nov 21
Provided herein are methods of treating acute myeloid leukemia (AML) and multiple myeloma (MM) by administering an effective amount of a cell population comprising natural killer cells, wherein the cell population comprising natural killer cells is produced by a three-stage method comprising culturing a population of hematopoietic stem or progenitor cells in media comprising stem cell mobilizing factors, e.g., three-stage methods of producing NK cells in media comprising stem cell mobilizing factors starting with hematopoietic stem or progenitor cells from cells of the placenta, for example, from placental perfusate (e.g., human placental perfusate) or other tissues, for example, umbilical cord blood or peripheral blood.
Steven A. Fischkoff, Uri Herzberg, Lin Kang, Brian Murphy, Andrea Nordberg, Vanessa Voskinarian-Berse, Keith Wilson, Xiaokui Zhang, Han Myint, Mohamad Hussein, Robert J Hariri
Filed: 5 May 17
Placenta-derived adherent cell exosomes and uses thereof
16 Nov 21
Provided herein are compositions of placenta-derived adherent cell exosomes and methods of making and using the same.
Eric Law, Andrew Morschauser, Aleksander Francki, Jennifer Paredes, Kathy Karasiewicz-Mendez, Allan Reduta, Vladimir Jankovic, Ivana Djuretic, Robert J. Hariri
Filed: 10 Jan 20
Cell Composition and Methods of Making the Same
23 Sep 21
Provided herein are improved methods for the formulation of compositions comprising placental stem cells, and improved compositions and cell formulations produced thereby.
Andy ZEITLIN, Gregory RUSSOTTI, Shuyang HE, Ajai PAL, Hong CHEN, Thomas BRIEVA, Ryan SHORR, Brian MURPHY
Filed: 7 Jun 21
Devices and Methods for Thawing Biological Material
19 Aug 21
Provided herein are devices and methods for thawing frozen biological material.
Brian Murphy, Robert J. Hariri
Filed: 30 Apr 21
Treatment of pain using placental stem cells
17 Aug 21
Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture plastic adherent placental stem cells (PDAC™).
Uri Herzberg, Jodi P. Gurney, Robert J. Hariri
Filed: 5 Aug 19
Enhanced Placental Stem Cells and Uses Thereof
5 Aug 21
Provided herein are placental stem cells that exhibit increased survival (“enhanced placental stem cells”), compositions comprising such placental stem cells, and methods of using such placental stem cells and compositions.
Stewart Abbot, Kathy Karasiewicz-Mendez, Xiaokui Zhang
Filed: 15 Apr 19
Angiogenesis Using Stimulated Placental Stem Cells
29 Jul 21
Provided herein are stimulated placental stem cells and methods of treating individuals having diseases or disorders of the circulatory system using stimulated placental cells.
Kathy E. KARASIEWICZ-MENDEZ, Aleksander FRANCKI, Jeffrey TURNER, Eric LAW, Jennifer PAREDES, Kristen LABAZZO, Hemlata RANA, Wolfgang HOFGARTNER, Robert J. HARIRI
Filed: 7 Jan 21
Methods for Isolation of Platelets
29 Jul 21
Provided herein are methods for the isolation of platelets, for example, isolation of platelets from umbilical cord blood.
Manoochehr KHORSHIDI, Robert J. HARIRI, Xiaokui ZHANG
Filed: 6 Apr 21
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