48 patents
Utility
Processes for preparation of soluble guanylate cyclase stimulators
5 Dec 23
The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC).
Song Xue, Vishnu Vardhan Reddy Karnati, Robert C. Livingston, Timothy Claude Barden, Wayne C. Schairer
Filed: 6 Jul 17
Utility
TREATMENT OF COGNITIVE IMPAIRMENT WITH A CNS-PENETRANT sGC STIMULATOR
23 Nov 23
Christopher John Winrow, Christopher Ian Wright, Chad Edward Glasser, Phillip M. Alday, Alexander Ross Arslan, David F. Kleinschmidt, Jacob Donoghue
Filed: 12 Oct 21
Utility
Novel Processes and Intermediates for the Preparation of Soluble Guanylate Cyclase Stimulators
26 Oct 23
Debra Jane Wallace, Fenger Zhou, Yuguang Wang, Takashi Nakai, Vishnu Vardhan Reddy Karnati, Wayne C. Schairer, William Kissel, Song Xue, Ahmad Hashash
Filed: 28 Apr 23
Utility
Process for preparation of soluble guanylate cyclase stimulators
3 Oct 23
Song Xue, Vishnu Vardhan Reddy Karnati, Robert C. Livingston
Filed: 30 Mar 22
Utility
SGC stimulators
22 Aug 23
Glen Robert Rennie, Rajesh R. Iyengar, Thomas Wai-Ho Lee, Paul Allan Renhowe, Joon Jung, Kim Tang
Filed: 27 Sep 21
Utility
Processes and intermediates for the preparation of soluble guanylate cyclase stimulators
25 Jul 23
Debra Jane Wallace, Fenger Zhou, Yuguang Wang, Takashi Nakai, Vishnu Vardhan Reddy Karnati, Wayne C. Schairer, William Kissel, Song Xue, Ahmad Hashash
Filed: 8 Oct 21
Utility
Treatment of CNS diseases with sGC stimulators
4 Jul 23
The present disclosure relates to the use of stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations or dosage forms comprising them, alone or in combination with one or more additional agents, for the treatment of various CNS diseases, wherein an increase in sGC stimulation, or an increase in the concentration of nitric oxide (NO), or cyclic guanosine 3′,5′-monophosphate (cGMP) or both, or an upregulation of the NO pathway is desirable.
Joon Jung, Thomas Wai-Ho Lee, Rajesh R. Iyengar, Nicholas Robert Perl, Peter Germano, Maria D. Ribadeneira, Kim Tang
Filed: 7 Nov 17
Utility
Process for Preparing Soluble Guanylate Cyclase Stimulators
27 Apr 23
The invention relates to novel methods for preparing 3-substituted 1,2,4-triazole compounds as sGC stimulators and their synthetic precursors.
Thomas Storz
Filed: 28 Sep 22
Utility
DEUTERATED sGC STIMULATORS
27 Apr 23
Thomas Wai-Ho Lee, Debra Jane Wallace
Filed: 25 Mar 21
Utility
sGC STIMULATORS
6 Apr 23
Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, Lei Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
Filed: 20 Dec 21
Utility
CRYSTALLINE FORMS OF AN sGC STIMULATOR
30 Mar 23
The present disclosure relates to crystalline forms of 8-(2-fluorobenzyl)-6-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)imidazo[1,2-a]pyrazine, which are useful as a stimulator of soluble guanylate cyclase (sGC).
Kwame Wiredu Nti-Addae, Leena Kumari Prasad, Thomas Storz
Filed: 28 Sep 22
Utility
Solid forms of an sGC stimulator
7 Feb 23
Vasu Sethuraman, Ahmad Hashash, Song Xue, Robert C. Livingston, Kwame Wiredu Nti-Addae
Filed: 29 Dec 20
Utility
Process for preparing soluble guanylate cyclase stimulators
11 Oct 22
Thomas Storz
Filed: 7 Mar 19
Utility
Crystalline forms of 8-(2-fluorobenzyl)-6-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)imidazo[1,2-a]pyrazine as sGC stimulators
11 Oct 22
Kwame W. Nti-Addae, Leena Kumari Prasad, Thomas Storz
Filed: 7 Mar 19
Utility
Novel Process for Preparation of Soluble Guanylate Cyclase Stimulators
21 Jul 22
Song Xue, Vishnu Vardhan Reddy Karnati, Robert C. Livingston
Filed: 30 Mar 22
Utility
Treatment of metabolic syndrome with an sGC stimulator
19 Jul 22
The present invention provides a method of treating a subject with metabolic syndrome by administering a stimulator of soluble guanylate cyclase (sGC) (Compound I) either alone or in combination therapy with a blood glucose lowering (antihyperglycemic or antidiabetes) medication, a blood pressure lowering (anti-hypertensive) medication, an anti-hyperlipidemic medication, or combinations thereof.
John P. Hanrahan, Albert Thomas Profy, James D. Wakefield
Filed: 14 Sep 18
Utility
Use of sGC stimulators for the treatment of nonalcoholic steatohepatitis (NASH)
14 Jun 22
The present disclosure relates to methods, uses, pharmaceutical compositions and kits comprising an sGC stimulator or a pharmaceutically acceptable salt thereof, alone or in combination with one or more additional therapeutic agents, for the treatment of Nonalcoholic Steatohepatitis (NASH).
G-Yoon Jamie Im, Mark G. Currie, James Edward Sheppeck, Paul Allan Renhowe, Pei Ge, Jaime L. Masferrer
Filed: 31 Jan 17
Utility
Processes for preparation of soluble guanylate cyclase stimulators
3 May 22
Song Xue, Vishnu Vardhan Reddy Karnati, Robert C. Livingston
Filed: 6 Jul 17
Utility
Processes and intermediates for the preparation of soluble guanylate cyclase stimulators
15 Mar 22
Debra Jane Wallace, Fenger Zhou, Yuguang Wang, Takashi Nakai, Vishnu Vardhan Reddy Karnati, Wayne C. Schairer, William Kissel, Song Xue, Ahmad Hashash
Filed: 10 Jan 19
Utility
Novel Processes and Intermediates for the Preparation of Soluble Guanylate Cyclase Stimulators
27 Jan 22
Debra Jane Wallace, Fenger Zhou, Yuguang Wang, Takashi Nakai, Vishnu Vardhan Reddy Karnati, Wayne C. Schairer, William Kissel, Song Xue, Ahmad Hashash
Filed: 8 Oct 21