573 patents
Page 5 of 29
Utility
Methods for Identification of Antigen-binding Molecules
5 Oct 23
Provided herein are methods for identification of antigen binding molecules such as antibodies from a sample by exposing the antigen binding molecules to an antigen conjugated to an oligonucleotide.
Wyatt James MCDONNELL, Michael John Terry STUBBINGTON, Geoffrey P. MCDERMOTT, David Michael PATTERSON
Filed: 3 Nov 22
Utility
Single cell analysis of transposase accessible chromatin
3 Oct 23
Methods and systems for sample preparation techniques that allow amplification (e.g., whole genome amplification) and sequencing of chromatin accessible regions of single cells are provided.
Zahra Kamila Belhocine, Geoffrey McDermott, Francesca Meschi, Xinying Zheng
Filed: 1 Oct 21
Utility
Methods for spatial analysis using targeted RNA depletion
3 Oct 23
Provided herein are methods for spatial analysis using targeted RNA depletion.
Caroline Julie Gallant, Linda Kvastad
Filed: 23 Dec 22
Utility
Lentiviral-free Cytosolic Delivery of Payloads Via Aptamers
28 Sep 23
Provided herein are compositions, systems, methods, and kits for internalizing a payload into a cell via aptamer-mediated deliver.
Wyatt James MCDONNELL
Filed: 5 Dec 22
Utility
Methods and Compositions Related to Microsphere Surface Gelation
28 Sep 23
The present disclosure relates generally to compositions and methods for generating hydrogel coatings on features.
Shalini GOHIL, Shea Thompson LANCE, Geoffrey P. MCDERMOTT, David Michael PATTERSON, Andrew D. PRICE
Filed: 22 Mar 23
Utility
Systems and Methods for Spatial Analysis of Analytes Using Fiducial Alignment
28 Sep 23
Systems and methods for spatial analysis of analytes are provided.
Dongyao Li
Filed: 14 Feb 23
Utility
Electrophoretic methods for spatial analysis
26 Sep 23
The present disclosure provides electrophoretic systems, methods and compositions for spatial analysis, which can serve to magnify or demagnify spatial resolution of analytes of interest that are captured using electrophoresis.
Hanyoup Kim, Augusto Manuel Tentori, Rajiv Bharadwaj
Filed: 4 Mar 21
Utility
Selective Enzymatic Gelation
21 Sep 23
The present disclosure provides methods, compositions, and systems for selective enzymatic gelation of cells, e.g., immune cells, contained in partitions.
Shalini GOHIL, Joshua DELANEY, Yi LUO, Adam LOWE, Jason C. BELL, Michael John Terry STUBBINGTON, Wyatt James MCDONNELL
Filed: 22 Mar 23
Utility
Methods, Compositions, Kits, and Systems for Enhancing Analyte Capture for Spatial Analysis
21 Sep 23
Provided herein are methods of enhancing spatial resolution of an analyte using sandwich maker system.
David Sukovich, Hanyoup Kim, Jerald Sapida, Spontaneous Rose McKnight Russell, Layla Katiraee, Augusto Manuel Tentori
Filed: 3 May 23
Utility
Methods for Printing Cells and Generating Arrays of Barcoded Cells
21 Sep 23
This disclosure relates to compositions and methods for analyzing single cells using cell printing and spatial analysis.
Rajiv Bharadwaj
Filed: 24 May 23
Utility
Methods for identifying a location of an RNA in a biological sample
19 Sep 23
Provided herein are methods of identifying a location of an RNA in a sample that include: (a) contacting the sample with an array comprising capture probes, where a capture probe comprises a capture domain and a spatial barcode; (b) releasing the RNA from the sample; (c) extending a 3′ end of the capture probe using the capture domain-bound RNA as a template; (d) generating nick(s) in the extended capture probe-hybridized RNA and performing random-primed DNA synthesis; (e) performing end repair on the second strand DNA molecule; (f) adding a single adenosine nucleotide to the 3′ end of the extended capture probe; (g) ligating a double-stranded sequencing adaptor to the double-stranded DNA product; and (h) determining all or a part of the sequence of the RNA, and the sequence of the spatial barcode, or complements thereof, and using the determined sequences to identify the location of the RNA in the sample.
Marlon Stoeckius
Filed: 6 Jul 21
Utility
Nucleic Acid Library Methods
14 Sep 23
Provided herein are methods, compositions, and kits for removing a portion of a sequence in a member of a nucleic acid library.
Caroline Julie Gallant, Marlon Stoeckius, Katherine Pfeiffer
Filed: 18 May 23
Utility
Concatemeric Detectable Probes and Related Methods
14 Sep 23
The present disclosure relates in some aspects to methods, probes, and kits for detection of a target analyte in a sample.
Felice Alessio BAVA
Filed: 10 Mar 23
Utility
De-crosslinking Compounds and Methods of Use for Spatial Analysis
14 Sep 23
Provided herein are methods for de-crosslinking fixed biological samples (e.g., fixed biological samples including aminal crosslinks).
James Michael Chell, Joshua Delaney, Rapolas Spalinskas, Aleksandra Jurek, Meiliana Tjandra
Filed: 22 Dec 20
Utility
Method for Transposase Mediated Spatial Tagging and Analyzing Genomic Dna In a Biological Sample
14 Sep 23
The present disclosure relates to materials and methods for spatially analyzing nucleic acids fragmented with a transposase enzyme, optionally complexed to an antibody-binding moiety (e.g., an antibody-binding protein) bound to an antibody for at least one chromatin protein, in a biological sample.
Anna-Maria Katsori, Christina Galonska, Paulius Mielinis, Marlon Stoeckius
Filed: 26 May 23
Utility
Systems and methods for identifying morphological patterns in tissue samplers
12 Sep 23
A discrete attribute value dataset is obtained that is associated with a plurality of probe spots each assigned a different probe spot barcode.
Jeffrey Clark Mellen, Jasper Staab, Kevin J. Wu, Neil Ira Weisenfeld, Florian Baumgartner, Brynn Claypoole
Filed: 18 Oct 22
Utility
Methods, compositions, and kits for blocking a capture probe on a spatial array
12 Sep 23
Provided are methods for determining a location of a target nucleic acid in a biological sample including: disposing the biological sample onto an array including a plurality of capture probes, where a first capture probe includes a first spatial barcode and a capture domain and a second capture probe includes a second spatial barcode and the capture domain.
Jennifer Chew, David Michael Patterson
Filed: 9 Mar 23
Utility
Generating capture probes for spatial analysis
12 Sep 23
The present disclosure relates to compositions and methods for generating capture probes on a substrate for identifying the location of analytes in a biological sample.
Eswar Prasad Ramachandran Iyer
Filed: 26 Oct 22
Utility
Devices and Methods for Reversible Assembly of a Flowcell
7 Sep 23
Flowcell devices configured for reversible assembly, and methods of assembly, disassembly, and use thereof are provided.
Siyuan XING, Pratomo Putra Alimsijah, Denis Pristinski, David Morgan, Rajiv Bharadwaj, Augusto Manuel Tentori, Francis Marcogliese, Yiran Zhang
Filed: 16 Feb 23
Utility
Multiple Readout Signals for Analyzing a Sample
7 Sep 23
In some aspects disclosed herein are methods and compositions for detecting analytes such as a plurality of nucleic acid molecules in a biological sample, said method comprising generating and analyzing a first detectable signal and a second detectable signal corresponding to a first target sequence and a second target sequence, respectively.
Malte KÜHNEMUND, Marco MIGNARDI
Filed: 20 Jan 23