573 patents
Page 7 of 29
Utility
Methods for Processing Nucleic Acid Molecules
27 Jul 23
The present disclosure provides methods, systems, and kits for processing nucleic acid molecules.
Zahra Kamila Belhocine, Jason Bell, Jerald Sapida, Katrina Sullivan-Bibee
Filed: 17 Aug 22
Utility
Methods and Systems for Characterizing Analytes from Individual Cells or Cell Populations
27 Jul 23
The present disclosure provides methods of processing or analyzing a sample.
Tarjei Sigurd Mikkelsen, Eswar Prasad Ramachandran lyer, Andrew Kohlway, Luigi Jhon Alvarado Martinez, Katherine Pfeiffer, Andrew D. Price
Filed: 16 Mar 23
Utility
Rna Templated Ligation
20 Jul 23
The present application provides methods for detecting a target nucleic acid molecule in a sample comprising contacting said sample with a ligatable probe comprising one or more parts and allowing said probe to hybridise to the target nucleic acid molecule, ligating any probe which has hybridised to the target nucleic acid molecule, amplifying the ligated probe, and detecting the amplification product, thereby to detect the target nucleic acid molecule, wherein said probes comprise at least one ribonucleotide at or near to a ligation site and/or wherein the probe or a probe part comprises an additional sequence 5′ to a target-specific binding site which is not hybridised to the target nucleic acid molecule upon hybridisation of the probe to the target nucleic acid molecule and forms a 5′ flap containing one or more nucleotides at its 3′ end that is cleaved prior to ligation, and methods of synthesising a DNA molecule with Phi29 DNA polymerase using a template nucleic acid molecule comprising at least one ribonucleotide.
Mats NILSSON, Malte KÜHNEMUND, Tomasz KRZYWKOWSKI
Filed: 13 Jan 23
Utility
Methods of Determining a Surgical Margin and Methods of Use Thereof
20 Jul 23
Provided herein are methods of determining a surgical margin and the site and size of a tissue to be resected from a subject, and methods of use thereof.
Smritee Dadhwal
Filed: 10 Mar 23
Utility
Spatially-tagged Analyte Capture Agents for Analyte Multiplexing
20 Jul 23
Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.
Cedric Uytingco, James Michael Chell, Marlon Stoeckius, Albert Dale Kim, Dulce Ovando Morales, Andrej Hartnett, Yifeng Yin, Jennifer Chew
Filed: 26 Jan 23
Utility
Methods and devices for magnetic separation
18 Jul 23
Devices, systems, and their methods of use, for sorting or separating magnetic particles are provided.
Alireza Salmanzadeh
Filed: 7 May 21
Utility
Enhancing specificity of analyte binding
18 Jul 23
Methods for enhancing specificity of an analyte binding moiety or probe oligonucleotide to an analyte are provided herein.
Marlon Stoeckius
Filed: 11 Jan 22
Utility
Methods for printing cells and generating arrays of barcoded cells
18 Jul 23
This disclosure relates to compositions and methods for analyzing single cells using cell printing and spatial analysis.
Rajiv Bharadwaj
Filed: 19 Jan 21
Utility
Methods and systems for cell and bead processing
18 Jul 23
The present disclosure provides methods and systems for cell and bead processing or analysis.
Christopher Hindson, Andrew D. Price, Michael Schnall-Levin
Filed: 7 Jun 19
Utility
Cold Protease Treatment Method for Preparing Biological Samples
13 Jul 23
The present disclosure provides methods of preparing a fixed biological sample for use in an assay, wherein the method includes treatment of the sample with a low temperature active protease, optionally, in combination with an un-fixing reagent.
Albert Kim
Filed: 6 Oct 22
Utility
Spatial Analysis to Detect Sequence Variants
13 Jul 23
Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample.
Christina Galonska, Marco Mignardi
Filed: 7 Mar 23
Utility
Methods of Releasing an Extended Capture Probe from a Substrate and Uses of the Same
13 Jul 23
Provided herein are methods of releasing an extended capture probe from a substrate and uses of the same.
Zachary W. Bent, Jennifer Chew, Yifeng Yin
Filed: 24 Feb 23
Utility
Compositions and Methods for Analyte Detection
6 Jul 23
The present disclosure provides methods, systems and compositions for detecting nucleic acid sequences in a biological sample having a three-dimensional matrix.
Evan Daugharthy, Richard Terry, Conor Camplisson, David Barclay, Tyler Miselis, Hong Chen, Shoshoni Droz
Filed: 27 Jul 22
Utility
Methods, Compositions, and Kits for Blocking a Capture Probe on a Spatial Array
6 Jul 23
Provided herein are methods, compositions, and kits for determining a location of a target analyte in a biological sample that include the use of terminal deoxynucleotidyl transferase.
Jennifer Chew, David Michael Patterson
Filed: 9 Mar 23
Utility
Spatial transcriptomics for antigen-receptors
4 Jul 23
Provided herein are methods, compositions, and kits for the detection of immune cell clonotypes and immune cell analytes within a biological sample.
Camilla Engblom, Kim Thrane, Jeffrey Mold, Jonas Frisen, Joakim Lundeberg, Qirong Lin
Filed: 15 Dec 21
Utility
Methods, Compositions, and Systems for Capturing Probes And/or Barcodes
29 Jun 23
Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.
Hanyoup Kim, David Sukovich, Layla Katiraee, Augusto Manuel Tentori
Filed: 3 Mar 23
Utility
Methods and Systems for Processing Polynucleotides
29 Jun 23
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization.
Phillip Belgrader, Zachary Bent, Rajiv Bharadwaj, Vijay Kumar Sreenivasa Gopalan, Josephine Harada, Christopher Hindson, Mohammad Rahimi Lenji, Michael Ybarra Lucero, Geoffrey McDermott, Elliott Meer, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Serge Saxonov, John R. Stuelpnagel, Jessica Michele Terry, Tobias Daniel Wheeler, Indira Wu, Solongo Batjargal Ziraldo, Stephane Claude Boutet, Sarah Taylor, Niranjan Srinivas
Filed: 24 Aug 22
Utility
Methods for sorting particles
30 May 23
Methods and systems for sorting particles are provided.
Rajiv Bharadwaj, Michael Schnall-Levin, Anthony Makarewicz, Steven Short
Filed: 28 Jun 22
Utility
Spatial analysis of DNA methylation
30 May 23
Provided herein are methods of identifying a methylation status of an analyte in a biological sample.
Layla Katiraee, Michael Schnall-Levin, Christina Galonska, Marlon Stoeckius
Filed: 5 Aug 22
Utility
Circular Probes and Methods for Sample Analysis
25 May 23
The present disclosure relates in some aspects to methods and compositions for analyzing a target nucleic acid, such as in situ detection of a region of interest in a polynucleotide in a cell or tissue sample.
Zahra Kamila BELHOCINE, Justin COSTA, Eswar Prasad RAMACHANDRAN IYER
Filed: 23 Nov 22