416 patents
Utility
Devices, Methods, and Systems for Improved Droplet Recovery
18 Jan 24
Devices, methods, and systems for generating droplets are provided.
Brenden Janatpour BROWN, Ivan AKHREMICHEV, Daniel FREITAS, Martin SAUZADE
Filed: 26 Sep 23
Utility
Methods for Spatial Analysis Using Rolling Circle Amplification
18 Jan 24
Provided herein are methods of identifying a location of an analyte in a biological sample using padlock oligonucleotides and rolling circle amplification.
Marco Mignardi
Filed: 21 Oct 21
Utility
Methods for Spatial Analysis Using Targeted Rna Depletion
18 Jan 24
Provided herein are methods for spatial analysis using targeted RNA depletion.
Caroline Julie Gallant, Linda Kvastad
Filed: 15 Aug 23
Utility
Method for Transposase-mediated Spatial Tagging and Analyzing Genomic Dna In a Biological Sample
18 Jan 24
The present disclosure relates to materials and methods for spatially analyzing nucleic acids that have been fragmented with a transposase enzyme, alone or in combination with other types of analytes.
Michael Schnall-Levin, Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Patrik Stahl, Jonas Frisen, Maja Marklund, Enric Llorens Bobadilla
Filed: 6 Jul 23
Utility
Probe-based Analysis of Nucleic Acids and Proteins
18 Jan 24
Provided herein are systems and methods for processing biomolecules (e.g., nucleic acid molecules, proteins) from a sample.
Katherine Pfeiffer, Andrew Scott Kohlway, Andrew John Hill, Paul Eugene Lund, Jawad N. Abousoud, Sharmila Chatterjee Bhattacharjee, Ryan Stott
Filed: 20 Sep 23
Utility
Multiplex Capture of Gene and Protein Expression from a Biological Sample
11 Jan 24
Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.
Jennifer Chew, Joseph Francis Shuga, Patrick Roelli, Denise Cheung, Alexander Hermes, Yifeng Yin, Naishitha Anaparthy, Ryo Hatori, Marlon Stoeckius, Rapolas Spalinskas, Anna-Maria Katsori, Cedric Uytingco, Mesruh Turkekul, David Sukovich, Christina Galonska, Aleksandra Jurek, Octavian Marian Bloju
Filed: 6 Jul 23
Utility
Analysis of Antigen and Antigen Receptor Interactions
4 Jan 24
The present disclosure relates in some aspects to methods of contacting a biological sample (e.g., fresh or frozen tissue sample) with peptide-loaded detection complexes.
Søren Nyboe JAKOBSEN, Malte KÜHNEMUND
Filed: 5 May 23
Utility
Methods and Systems for Processing Polynucleotides
4 Jan 24
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing.
Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol, Rajiv Bharadwaj, Xinying Zheng, Phillip Belgrader
Filed: 13 Sep 23
Utility
Compositions, Systems and Methods for Crispr-based Enzyme Optimization
4 Jan 24
Provided herein are reaction mixtures, compositions, systems, methods, and kits for assessing enzymatic activity.
Michael Gibbons
Filed: 5 May 23
Utility
Probe-based Analysis of Nucleic Acids and Proteins
4 Jan 24
Provided herein are systems and methods for processing biomolecules (e.g., nucleic acid molecules, proteins) from a sample.
Katherine Pfeiffer, Andrew Scott Kohlway, Andrew John Hill, Paul Eugene Lund, Jawad N. Abousoud, Sharmila Chatterjee Bhattacharjee, Ryan Stott
Filed: 30 Jun 23
Utility
Methods and Systems for Processing Polynucleotides
4 Jan 24
This disclosure provides methods and compositions for sample processing, particularly for sequencing applications.
Christopher Hindson, Michael Schnall-Levin, Andrew Price, Paul Hardenbol, Yuan Li
Filed: 17 Mar 23
Utility
Increasing Efficiency of Spatial Analysis In a Biological Sample
4 Jan 24
Disclosed herein are methods of amplifying an analyte in a biological sample using a bridging oligonucleotide that hybridizes to a captured analyte.
Felice Alessio Bava
Filed: 23 Jun 23
Utility
Click Chemistry-based Dna Photo-ligation for Manufacturing of High-resolution Dna Arrays
4 Jan 24
The present disclosure relates in some aspects to methods and compositions for light-controlled in situ surface patterning of a substrate using a Click chemistry reaction.
Jonathan CHENG, David Michael Patterson
Filed: 28 Jun 23
Utility
Methods and Systems for Cell and Bead Processing
4 Jan 24
The present disclosure provides methods and systems for cell and bead processing or analysis.
Christopher Hindson, Andrew D. Price, Michael Schnall-Levin
Filed: 2 Jun 23
Utility
Methods, Compositions, and Systems for Improved In Situ Detection of Analytes and Spatial Analysis
28 Dec 23
Provided herein are methods, compositions, and systems for improved in situ detection of analytes and spatial analysis using, e.g., a sequencing readout.
David Sukovich, Felice Alessio Bava, Augusto Manuel Tentori, Hanyoup Kim, Amanda Janesick
Filed: 7 Sep 23
Utility
Methods and Compositions for Probe Detection and Readout Signal Generation
28 Dec 23
In some aspects disclosed herein are methods and compositions for detecting an analyte such as a target nucleic acid in a biological sample, said method comprising generating and analyzing a detectable signal associated with the target nucleic acid and a separate signal associated with a region of interest in the target nucleic acid.
Felice Alessio BAVA, Marco Mignardi
Filed: 14 Apr 23
Utility
Methods, Compositions, and Systems for Detecting Exogenous Nucleic Acids
28 Dec 23
Provided herein are methods for capturing an exogenous probe and/or a capture handle sequence to a capture domain of a capture probe.
Hardeep Pal Singh, Augusto Manuel Tentori
Filed: 22 Jun 23
Utility
Methods and Compositions for Analyzing Immune Infiltration In Cancer Stroma to Predict Clinical Outcome
21 Dec 23
Provided herein are methods for analyzing immune cell infiltration in a cancer stromal region of a biological sample obtained from a subject using machine learning modules.
Florian Baumgartner, Valeria Giangarra, Sarah Taylor, Yifeng Yin
Filed: 18 Nov 21
Utility
Probe-based Analysis of Nucleic Acids and Proteins
14 Dec 23
Provided herein are systems and methods for processing biomolecules (e.g., nucleic acid molecules, proteins) from a sample.
Katherine Pfeiffer, Andrew Scott Kohlway, Andrew John Hill, Paul Eugene Lund
Filed: 22 Aug 23
Utility
Method for Concentrating Droplets In an Emulsion
7 Dec 23
The invention provides devices for forming droplets and concentrating droplets, and methods of their use.
Ivan AKHREMICHEV, Lynna CHEN, Martin SAUZADE
Filed: 23 Aug 23