156 patents
Utility
Methods and compositions for nucleic acid analysis
16 Jan 24
The present invention is directed to methods, compositions and systems for analyzing sequence information while retaining structural and molecular context of that sequence information.
Xinying Zheng, Serge Saxonov, Michael Schnall-Levin, Kevin Ness, Rajiv Bharadwaj
Filed: 12 Sep 22
Utility
Systems and methods for metabolome analysis
16 Jan 24
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing.
Luigi Jhon Alvarado Martinez
Filed: 19 Jan 23
Utility
Methods, compositions, and systems for spatial analysis of analytes in a biological sample
16 Jan 24
Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.
Hanyoup Kim, David Sukovich, Layla Katiraee, Augusto Manuel Tentori, Lauren Gutgesell, Janine Hensel, Seayar Mohabbat
Filed: 27 Apr 23
Utility
Simultaneous spatio-temporal measurement of gene expression and cellular activity
9 Jan 24
Provided herein are methods for simultaneous spatio-temporal measurement of gene expression and cellular activity.
Cedric Uytingco, Layla Katiraee, Kristen Pham
Filed: 7 Mar 23
Utility
Magnetic separator for an automated single cell sequencing system
2 Jan 24
A magnetic separator is disclosed.
Pratomo Alimsijah, John Richard Chevillet
Filed: 30 Mar 20
Utility
Nucleic acid library methods
2 Jan 24
Provided herein are methods, compositions, and kits for removing a portion of a sequence in a member of a nucleic acid library.
Caroline Julie Gallant, Marlon Stoeckius, Katherine Pfeiffer
Filed: 7 Feb 23
Utility
Spatial transcriptomics for antigen-receptors
19 Dec 23
Provided herein are methods, compositions, and kits for the detection of immune cell clonotypes and immune cell analytes within a biological sample.
Camilla Engblom, Kim Thrane, Jeffrey Mold, Jonas Frisen, Joakim Lundeberg, Qirong Lin
Filed: 10 May 23
Utility
Methods and systems for multiplexing of droplet based assays
19 Dec 23
Compositions, methods, and systems are provided for sample preparation techniques and sequencing of macromolecular constituents derived from a cell (i.e., a cell bead) in a multiplexed reaction.
Zahra Kamila Belhocine, Andrew D. Price
Filed: 8 Jan 20
Utility
Nucleic acid library methods
12 Dec 23
Provided herein are methods, compositions, and kits for removing a portion of a sequence in a member of a nucleic acid library.
Caroline Julie Gallant, Marlon Stoeckius, Katherine Pfeiffer
Filed: 18 May 23
Utility
Methods, compositions, and kits for blocking a capture probe on a spatial array
12 Dec 23
Provided herein are methods for determining a location of a protein in a biological sample including: disposing the sample onto an array comprising a plurality of capture probes, where a first and second capture probe include a first and second spatial barcode, respectively, and a capture domain.
Jennifer Chew, David Michael Patterson
Filed: 27 Jul 23
Utility
Microfluidic channel networks for partitioning
5 Dec 23
Provided are microfluidics systems, devices, and networks for generating partitions.
Tobias Daniel Wheeler, Bill Kengli Lin, Mohammad Rahimi Lenji, Anthony Makarewicz, Rajiv Bharadwaj
Filed: 27 Apr 20
Utility
Methods and compositions for partitioning a biological sample
5 Dec 23
This disclosure relates to compositions and methods for analyzing a tissue section from a biological sample.
Felice Alessio Bava
Filed: 10 Feb 21
Utility
Methods for spatial analysis using rolling circle amplification and detection probes
28 Nov 23
Provided herein are methods of improving sensitivity of spatial detection of an analyte in a biological sample using splint oligonucleotides, circularized second strands, and rolling circle amplification.
Eswar Prasad Ramachandran Iyer, Yifeng Yin, Sultan Doganay Tuncer
Filed: 19 Nov 21
Utility
Compositions and methods of making gene expression libraries
21 Nov 23
Provided herein are methods of detecting target nucleic acids and uses of the same.
Zachary Bent, Marlon Stoeckius
Filed: 29 Jan 21
Utility
Spatially-tagged analyte capture agents for analyte multiplexing
7 Nov 23
Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a nucleic acid analyte in a biological sample.
Cedric Uytingco, James Michael Chell, Marlon Stoeckius, Albert Dale Kim, Dulce Ovando Morales, Andrej Hartnett, Yifeng Yin, Jennifer Chew
Filed: 26 Jan 23
Utility
Methods for spatial analysis using RNA-templated ligation
24 Oct 23
Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Layla Katiraee
Filed: 26 Aug 22
Utility
Methods of determining a surgical margin and methods of use thereof
10 Oct 23
Provided herein are methods of determining a surgical margin and the site and size of a tissue to be resected from a subject, and methods of use thereof.
Smritee Dadhwal
Filed: 10 Mar 23
Utility
Single cell analysis of transposase accessible chromatin
3 Oct 23
Methods and systems for sample preparation techniques that allow amplification (e.g., whole genome amplification) and sequencing of chromatin accessible regions of single cells are provided.
Zahra Kamila Belhocine, Geoffrey McDermott, Francesca Meschi, Xinying Zheng
Filed: 1 Oct 21
Utility
Methods for spatial analysis using targeted RNA depletion
3 Oct 23
Provided herein are methods for spatial analysis using targeted RNA depletion.
Caroline Julie Gallant, Linda Kvastad
Filed: 23 Dec 22
Utility
Electrophoretic methods for spatial analysis
26 Sep 23
The present disclosure provides electrophoretic systems, methods and compositions for spatial analysis, which can serve to magnify or demagnify spatial resolution of analytes of interest that are captured using electrophoresis.
Hanyoup Kim, Augusto Manuel Tentori, Rajiv Bharadwaj
Filed: 4 Mar 21