156 patents
Page 5 of 8
Utility
Methods for spatial analysis using RNA-templated ligation
17 May 22
Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Felice Alessio Bava, Layla Katiraee
Filed: 1 Apr 21
Utility
Microfluidic surface-mediated emulsion stability control
22 Mar 22
A microfluidic emulsion droplet generation system and methods of use thereof are provided.
Rajiv Bharadwaj, Tobias Daniel Wheeler, Kevin Ness, Benjamin Hindson
Filed: 29 May 20
Utility
Methods and compositions for targeted nucleic acid sequence coverage
15 Mar 22
The present invention is directed to methods, compositions and systems for analyzing sequence information from targeted regions of a genome.
Mirna Jarosz, Michael Schnall-Levin
Filed: 24 Feb 16
Utility
Methods and systems for analysis of cell lineage
22 Feb 22
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell.
Michael Schnall-Levin
Filed: 4 Apr 19
Utility
Methods and systems for processing polynucleotides
15 Feb 22
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization.
Phillip Belgrader, Josephine Harada, Tarjei Sigurd Mikkelsen, Katherine Pfeiffer, Serge Saxonov, John R. Stuelpnagel
Filed: 12 Feb 21
Utility
Systems and methods for distributed resource management
8 Feb 22
Methods, nontransitory computer readable media, and systems are disclosed for servicing a job queue.
David Luther Alan Stafford, Adam David Azarchs, Alexander Y. Wong
Filed: 2 Oct 20
Utility
Gaskets for the distribution of pressures in a microfluidic system
8 Feb 22
A microfluidic system includes a microfluidic chip having a plurality of fluid channels, each fluid channel having an opening providing access to an interior of the fluid channel, and a gasket disposable on the microfluidic chip in an aligned configuration, the gasket including a first side configured to face the microfluidic chip in the aligned configuration, a second side opposite the first side, and an aperture extending through the gasket from the first side to the second side, the aperture being sized and positioned to allow a communication of pressure from the second side of the gasket to the openings of at least two fluid channels when the gasket is in the aligned configuration.
Tobias Daniel Wheeler, Rajiv Bharadwaj
Filed: 5 Dec 19
Utility
Single cell analysis of transposase accessible chromatin
14 Dec 21
Methods and systems for sample preparation techniques that allow amplification (e.g., whole genome amplification) and sequencing of chromatin accessible regions of single cells are provided.
Zahra Kamila Belhocine, Geoffrey McDermott, Francesca Meschi, Xinying Zheng
Filed: 30 Nov 18
Utility
Partitioning and processing of analytes and other species
7 Dec 21
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing.
Benjamin Hindson, Serge Saxonov, Kevin Ness, Paul Hardenbol, Christopher Hindson, Donald Masquelier, Mirna Jarosz, Michael Schnall-Levin
Filed: 25 Oct 18
Utility
Methods and systems for droplet-based single cell barcoding
7 Dec 21
Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
Zahra Kamila Belhocine, Rajiv Bharadwaj, Christopher Hindson, Michael Schnall-Levin, Bill Kengli Lin, Anthony Makarewicz, Pranav Patel, Andrew D. Price, Mohammad Rahimi Lenji, Tobias Daniel Wheeler, Yifeng Yin
Filed: 22 Mar 21
Utility
Methods and systems for processing polynucleotides
23 Nov 21
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization.
Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Katherine Pfeiffer, Stephane Claude Boutet
Filed: 29 Oct 20
Utility
Single cell analysis of transposase accessible chromatin
26 Oct 21
Methods and systems for sample preparation techniques that allow amplification (e.g., whole genome amplification) and sequencing of chromatin accessible regions of single cells are provided.
Zahra Kamila Belhocine, Geoffrey McDermott, Francesca Meschi, Xinying Zheng
Filed: 6 Apr 20
Utility
Systems and methods for quality control in single cell processing
26 Oct 21
Provided are systems and methods for analyzing a single cell application or experiment.
Zachary Bent, Paul Ryvkin, Jessica Michele Terry, Geoffrey McDermott, Meghan Leigh Flanders Frey
Filed: 6 Jun 19
Utility
Instrument systems for integrated sample processing
5 Oct 21
An integrated system for processing and preparing samples for analysis may include a microfluidic device including a plurality of parallel channel networks for partitioning the samples including various fluids, and connected to a plurality of inlet and outlet reservoirs, at least a portion of the fluids comprising reagents, a holder including a closeable lid hingedly coupled thereto, in which in a closed configuration, the lid secures the microfluidic device in the holder, and in an open configuration, the lid is a stand orienting the microfluidic device at a desired angle to facilitate recovery of partitions or droplets from the partitioned samples generated within the microfluidic device, and an instrument configured to receive the holder and apply a pressure differential between the plurality of inlet and outlet reservoirs to drive fluid movement within the channel networks.
Donald A. Masquelier, Benjamin Hindson, Kevin Ness, Rajiv Bharadwaj
Filed: 12 Feb 19
Utility
Methods and systems for macromolecule labeling
28 Sep 21
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from one or more cells.
Katherine Pfeiffer, Sarah Taylor, Michael Stubbington
Filed: 4 Apr 19
Utility
Systems and methods for nucleic acid sequence assembly
28 Sep 21
Determination of a nucleic acid sequence using sequence reads of the nucleic acid.
Michael Schnall-Levin, Iain MacCallum
Filed: 2 Nov 17
Utility
Microfluidic systems and methods of use
10 Aug 21
Microfluidic channels networks and systems are provided.
Rajiv Bharadwaj, Kevin Ness, Tobias Daniel Wheeler
Filed: 5 Nov 18
Utility
Capsule array devices and methods of use
3 Aug 21
This disclosure provides microwell capsule array devices.
Benjamin Hindson, Serge Saxonov, Michael Schnall-Levin
Filed: 23 Jul 19
Utility
Systems, methods, and media for de novo assembly of whole genome sequence data
3 Aug 21
Described are computer-implemented methods, systems, and media for de novo phased diploid assembly of nucleic acid sequence data generated from a nucleic acid sample of an individual utilizing nucleic acid tags to preserve long-range sequence context for the individual such that a subset of short-read sequence data derived from a common starting sequence shares a common tag.
David Jaffe, Patrick Marks, Michael Schnall-Levin, Neil Weisenfeld
Filed: 19 Aug 16
Utility
Methods and systems for processing polynucleotides
15 Jun 21
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing.
Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol
Filed: 20 Aug 20