3 patents
Utility
Combination Treatment with a P53 Reactivator and an Inhibitor of an Antiapoptotic BCL-2 Family Protein
27 Oct 22
Provided herein are methods of treating hyperproliferative malignancy in a subject using combination of a compound that can result in reactivation of mutant p53 and a Bcl-2 inhibitor or a Mcl-1 inhibitor.
Lars Abrahmsén, Anders Wennborg
Filed: 18 Sep 20
Utility
Method of Treatment and Pharmaceutical Dosage Form
31 Mar 22
The invention relates to a method of treatment of neoplastic disease in a patient with mutant TP53 with a combination of APR-246 and azacitidine, in which APR-246 is given as a fixed dose.
Karin Jorga
Filed: 2 Dec 19
Utility
QUINUCLIDINE-3-ONE Derivatives and Their Use In Cancer Treatment
10 Mar 22
The invention relates to certain substituted quinuclidine-3-one compounds for use in the treatment of hyperproliferative disease, such as cancer, and diseases associated with inflammation.
Lars Hagberg, Rune Ringom, Tim Blizzard
Filed: 20 Sep 19
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