10 patents
Utility
Engineered and Chimeric Nucleases
28 Dec 23
Disclosed herein are engineered nucleases and nuclease systems, including chimeric nucleases and chimeric nuclease systems.
Brian C. THOMAS, Christopher BROWN, Cristina BUTTERFIELD, Jyun-Liang LIN, Alan BROOKS, Morayma M. TEMOCHE-DIAZ, Greg COST, Rebecca LAMOTHE
Filed: 17 Nov 22
Utility
Base Editing Enzymes
23 Nov 23
The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
Brian C. THOMAS, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Jyun-Liang LIN
Filed: 31 May 23
Utility
Base Editing Enzymes
2 Nov 23
The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Brian C. Thomas
Filed: 7 Mar 23
Utility
Base Editing Enzymes
2 Nov 23
The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Brian C. Thomas
Filed: 8 Mar 23
Utility
Systems and Methods for Transposing Cargo Nucleotide Sequences
26 Oct 23
The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site.
Brian THOMAS, Christopher BROWN, Daniela S.A. GOLTSMAN, Cristina BUTTERFIELD, Lisa ALEXANDER, Jason LIU
Filed: 22 Mar 23
Utility
Class II, type V CRISPR systems
1 Aug 23
Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
Brian Thomas, Christopher Brown, Audra Devoto, Cristina Butterfield, Lisa Alexander, Daniela S. A. Goltsman, Justine Albers, Alan Brooks, Greg Cost, Morayma Temoche-Diaz, Cindy Castelle, Rebecca Lamothe
Filed: 28 Mar 22
Utility
Class II, Type V Crispr Systems
20 Jul 23
Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine B. ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
Filed: 6 Sep 22
Utility
Class II, Type II Crispr Systems
16 Feb 23
The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.
Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN
Filed: 5 Jul 22
Utility
Base Editing Enzymes
17 Nov 22
The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE
Filed: 15 Jun 22
Utility
Class II, Type V Crispr Systems
15 Sep 22
Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
Brian C. THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine B. ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
Filed: 28 Mar 22
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