11 patents
Utility
Chimeric Activation Receptors
14 Dec 23
The preset disclosure provides chimeric activation receptors comprising (i) a TGFβ-binding domain and (ii) a CD2 costimulatory domain.
Queenie M. VONG, Blythe D. SATHER
Filed: 22 Oct 21
Utility
Methods for Culturing Cells Expressing ROR1-BINDING Protein
5 Oct 23
Disclosed herein are methods of culturing immune cells in a medium comprising at least about 5 mM potassium ion, wherein the medium is capable of increasing the stemness of the immune cells.
Suman Kumar VODNALA, Veena KRISHNAMOORTHY, Spencer PARK, Queenie VONG, Blythe SATHER
Filed: 27 Oct 22
Utility
Methods for Culturing Cells Expressing C-jun
5 Oct 23
Disclosed herein are methods of culturing immune cells in a medium comprising at least about 5 mM potassium ion, wherein the medium is capable of increasing the stemness of the immune cells.
Suman Kumar VODNALA, Veena KRISHNAMOORTHY, Spencer PARK, Queenie VONG, Blythe SATHER
Filed: 27 Oct 22
Utility
NR4A-DEFICIENT Cells Expressing C-jun and Uses Thereof
16 Feb 23
The present disclosure provides methods of promoting a persistent effector function of immune cells, comprising modifying the cells to overexpress c-Jun and reduced levels of a NR4A gene and/or protein.
Viola LAM, Rachel Christina LYNN
Filed: 1 Jun 22
Utility
ROR1 Targeting Chimeric Antigen Receptor
26 Jan 23
The present disclosure relates to polynucleotides encoding a chimeric polypeptide comprising a c-Jun polypeptide, a ROR1-binding protein, and a truncated EGF receptor.
Spencer PARK, Queenie VONG, Blythe SATHER, Byoung RYU, Marc LAJOIE, Howell MOFFETT, Brian WEITZNER, Yun SONG, Scott BOYKEN, Neeraj SHARMA, Shobha POTLURI, Bijan BOLDAJIPOUR
Filed: 24 Feb 22
Utility
Codon-optimized Nucleotide Sequences Encoding an AP-1 Transcription Factor
29 Sep 22
Disclosed herein are polynucleotides comprising a nucleotide sequence encoding an AP-1 transcription factor (i.e., c-Jun).
Spencer PARK, Queenie VONG, Blythe SATHER, Byoung RYU, Marc LAJOIE
Filed: 24 Feb 22
Utility
Methods for Culturing Immune Cells
9 Jun 22
Suman Kumar VODNALA, Yogin PATEL, Nicholas P. RESTIFO
Filed: 23 Nov 21
Utility
Methods for Making, Compositions Comprising, and Methods of Using Rejuvenated T Cells
26 May 22
The present disclosure relates generally to methods of producing rejuvenated T cells, comprising, contacting T cells with at least one reprogramming factor and reactivating the contacted cells; and compositions and methods of using same.
Raul E. Vizcardo Sakoda, Nicholas Restifo, Richard D. Klausner, Yin Huang, Takuya Maeda, Naritaka Tamaoki, Yasuhiro Yamazaki
Filed: 23 Nov 21
Utility
Chimeric Antigen Receptor Spacers
9 Dec 21
The present disclosure related to chimeric antigen receptors (CARs) comprising immunoglobulin (Ig) derived spacers, e.g., hinge or loop regions, fragments thereof, or combinations thereof.
Marc Joseph LAJOIE, Brian Douglas WEITZNER, Scott Edward BOYKEN, Spencer PARK, Yun SONG
Filed: 12 May 21
Utility
Methods for Culturing Cells
28 Oct 21
The preset disclosure provides methods of culturing cells, e.g., pluripotent cells, multipotent cells, and/or immune cells (e.g., T cells, NK cells, and/or TILs) in a medium comprising at least about 5 mM potassium ion, wherein the medium is not hypertonic.
Suman Kumar VODNALA, Nicholas P. RESTIFO, Robert Langland EIL
Filed: 28 Apr 21
Utility
Novel Recombinant Cell Surface Markers
7 Oct 21
The present disclosure relates to EGFR-derived polypeptides containing short juxtamembrane sequences, nucleic acids encoding them, and methods of using them to improve cell surface expression of truncated EGFR markers.
Howell Franklin Moffett, Marc Joseph Lajoie, Scott Edward Boyken
Filed: 19 Mar 21
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