72 patents
Utility
Stat Degraders and Uses Thereof
18 Jan 24
The present invention provides compounds, compositions thereof, and methods of using the same.
Nan JI, Bin YANG, Xiaozhang ZHENG, Xiao ZHU
Filed: 17 Mar 21
Utility
Methods of treating mutant lymphomas
2 Jan 24
The present invention relates to methods of treating MYD88-mutant B-cell lymphomas using IRAK4 degrader.
Duncan Walker
Filed: 29 Jul 21
Utility
Double Degraders and Uses Thereof
28 Dec 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Matthew M. WEISS, Xiaozhang ZHENG, Xiao ZHU
Filed: 21 Oct 21
Utility
IRAK4 Degraders and Uses Thereof
21 Dec 23
The present invention relates to a method of treating autoimmune/autoinflammatory diseases and hematological malignancies in a subject.
Haojing RONG, Bradley ENERSON
Filed: 1 Sep 23
Utility
Crystalline Forms of Irak Degraders
21 Dec 23
The present disclosure relates generally to various forms, salts and compositions of compounds useful for the modulation of one or more interleukin-1 receptor-associated kinases (“IRAK”) via ubiquitination and/or degradation and uses of the same in the treatment various diseases.
Xiaozhang ZHENG, Don CORSON
Filed: 18 May 23
Utility
Irak Degraders and Uses Thereof
14 Dec 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello MAINOLFI, Nan JI, Arthur F. KLUGE, Matthew M. WEISS, Yi ZHANG
Filed: 24 Apr 23
Utility
Irak Degraders and Uses Thereof
16 Nov 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello MAINOLFI, Chris DE SAVI, Matthew M. WEISS, Xiao ZHU, Xiaozhang ZHENG, Bruce C. FOLLOWS
Filed: 31 Jan 23
Utility
IRAK degraders and uses thereof
7 Nov 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
Filed: 14 Feb 22
Utility
Irak Inhibitors and Uses Thereof
12 Oct 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Matthew M. WEISS
Filed: 28 Apr 21
Utility
IRAK degraders and uses thereof
10 Oct 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Matthew M. Weiss
Filed: 17 Dec 20
Utility
IRAK4 degraders and uses thereof
3 Oct 23
The present invention relates to a method of treating autoimmune/autoinflammatory diseases and hematological malignancies in a subject.
Haojing Rong, Brad Enerson
Filed: 15 Feb 22
Utility
Irak Degraders and Uses Thereof
28 Sep 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING
Filed: 10 May 23
Utility
Protein Degraders and Uses Thereof
21 Sep 23
The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
Nello Mainolfi, Nan Ji, Arthur F. Kluge
Filed: 18 Aug 22
Utility
IRAK4 Degraders and Uses Thereof
7 Sep 23
The present invention relates to IRAKIMiD degraders, their liquid formulations, and methods of use thereof for treating cancer.
Jared Gollob, Jeffrey Davis, Ashwin Gollerkeri, Reginald EWESUEDO, Alice McDonald, Vashali Dixit, Shu-Pei Wu, Michele Mayo, Haojing Rong, Sagar Agarwal, Bradley Enerson, Patrick Henrick, Rachelle Perea, Christopher Ho, William Leong, Duncan Walker
Filed: 13 Jan 23
Utility
Stat degraders and uses thereof
5 Sep 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Bin Yang, Yi Zhang
Filed: 10 Oct 22
Utility
IRAK4 Degraders and Synthesis Thereof
17 Aug 23
The present invention provides compounds, compositions thereof, and processes for preparing same.
William LEONG, Dharyl Charles WILSON
Filed: 28 Oct 22
Utility
IRAK degraders and uses thereof
15 Aug 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
Filed: 10 Feb 22
Utility
Deuterated Irak Degraders and Uses Thereof
10 Aug 23
The present invention provides deuterium-enriched compounds, compositions thereof, and methods of using the same.
Xiaozhang ZHENG
Filed: 3 Jun 21
Utility
Irak Degraders and Uses Thereof
3 Aug 23
The present invention provides methods for identifying or selecting a patient having an elevated level of an inflammatory biomarker, and methods for treating a disease or disorder in a patient comprising selecting a patient having an elevated level of an inflammatory biomarker, and administering to the patient an IRAK degrader.
Veronica CAMPBELL, Alice MCDONALD, Jared GOLLOB, Anthony SLAVIN
Filed: 17 Jun 21
Utility
Methods of Treating Cancer
27 Jul 23
The present invention relates to methods of treating solid cancers and hematological malignances using MDM2 degraders.
Stefanie SCHALM, Dapeng Chen, William Proctor, Joseph Growney, Juliet Williams, Brad Enerson, Yogesh Chutake, Michele Mayo, Jianfeng Qi, Chris Ho, Matthew M. Weiss, Haojing Rong
Filed: 15 Dec 22