72 patents
Page 3 of 4
Utility
Smarca Degraders and Uses Thereof
23 Mar 23
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiqitination and/or degradation by compounds.
Nan JI, Yi ZHANG, Matthew M. WEISS
Filed: 10 Jun 20
Utility
Stat Degraders and Uses Thereof
16 Mar 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello MAINOLFI, Nan Ji, Bin Yang, Yi Zhang
Filed: 4 May 22
Utility
Smarca Degraders and Uses Thereof
9 Mar 23
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiquitination and/or degradation by compounds.
Nan JI, Yi ZHANG, Matthew M. WEISS, Paul R. Fleming
Filed: 10 Jun 20
Utility
Irak Degraders and Uses Thereof
2 Mar 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING
Filed: 29 Jun 20
Utility
IRAK degraders and uses thereof
28 Feb 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Matthew M. Weiss, Xiaozhang Zheng, Xiao Zhu
Filed: 17 Dec 20
Utility
CRBN Ligands and Uses Thereof
9 Feb 23
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
Nello MAINOLFI, Nan JI, Yi ZHANG, Matthew M. WEISS
Filed: 11 May 22
Utility
CRBN ligands and uses thereof
29 Nov 22
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
Nello Mainolfi, Nan Ji, Arthur F. Kluge
Filed: 14 Jan 19
Utility
Mertk Degraders and Uses Thereof
10 Nov 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Nan Ji, Nello MAINOLFI, Matthew M. WEISS
Filed: 3 Jul 19
Utility
Protein Degraders and Uses Thereof
3 Nov 22
The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
Yi ZHANG, Nan JI, Arthur F. KLUGE, Matthew M. WEISS
Filed: 3 Jul 19
Utility
Protein degraders and uses thereof
1 Nov 22
The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
Nello Mainolfi, Nan Ji, Arthur F. Kluge
Filed: 14 Jan 19
Utility
STAT degraders and uses thereof
1 Nov 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Bin Yang, Yi Zhang
Filed: 6 Apr 20
Utility
Irak Degraders and Uses Thereof
27 Oct 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Matthew M. WEISS, Xiaozhang ZHENG, Xiao ZHU
Filed: 17 Dec 20
Utility
Smarca Degraders and Uses Thereof
20 Oct 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Yi ZHANG, Paul R. FLEMING, Xiao ZHU
Filed: 23 Dec 20
Utility
Irak Degraders and Uses Thereof
13 Oct 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello MAINOLFI, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
Filed: 14 Feb 22
Utility
Tricyclic CRBN Ligands and Uses Thereof
29 Sep 22
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
Nan JI, Arthur F. KLUGE, Matthew M. WEISS, Yi ZHANG
Filed: 24 Feb 22
Utility
Fused-glutarimide CRBN Ligands and Uses Thereof
8 Sep 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Nan JI, Michael d. SINTCHAK, Li ZHANG, Xiaozhang ZHENG
Filed: 15 Jul 20
Utility
IRAK4 Degraders and Uses Thereof
1 Sep 22
The present invention provides IRAK4 degraders, formulations and unit dosage forms thereof, and methods of use thereof.
Jared GOLLOB, Jeffrey DAVIS, Alice MCDONALD, Haojing RONG
Filed: 15 Feb 22
Utility
IRAK4 Degraders and Uses Thereof
1 Sep 22
The present invention relates to a method of treating autoimmune/autoinflammatory diseases and hematological malignancies in a subject.
Haojing RONG, Brad ENERSON
Filed: 15 Feb 22
Utility
CRBN ligands and uses thereof
14 Jun 22
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
Nello Mainolfi, Nan Ji, Yi Zhang, Matthew M. Weiss
Filed: 21 Sep 18
Utility
IRAK degraders and uses thereof
7 Jun 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
Filed: 2 Dec 19