19 patents
Utility
Methods of treating mutant lymphomas
2 Jan 24
The present invention relates to methods of treating MYD88-mutant B-cell lymphomas using IRAK4 degrader.
Duncan Walker
Filed: 29 Jul 21
Utility
IRAK degraders and uses thereof
7 Nov 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
Filed: 14 Feb 22
Utility
IRAK degraders and uses thereof
10 Oct 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Matthew M. Weiss
Filed: 17 Dec 20
Utility
IRAK4 degraders and uses thereof
3 Oct 23
The present invention relates to a method of treating autoimmune/autoinflammatory diseases and hematological malignancies in a subject.
Haojing Rong, Brad Enerson
Filed: 15 Feb 22
Utility
Stat degraders and uses thereof
5 Sep 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Bin Yang, Yi Zhang
Filed: 10 Oct 22
Utility
IRAK degraders and uses thereof
15 Aug 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
Filed: 10 Feb 22
Utility
IRAK degraders and uses thereof
25 Jul 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Matthew M. Weiss
Filed: 10 Oct 22
Utility
Crystalline forms of IRAK degraders
27 Jun 23
The present disclosure relates generally to various forms, salts and compositions of compounds useful for the modulation of one or more interleukin-1 receptor-associated kinases (“IRAK”) via ubiquitination and/or degradation and uses of the same in the treatment various diseases.
Xiaozhang Zheng, Don Corson
Filed: 3 Jun 21
Utility
Protein degraders and uses thereof
11 Apr 23
The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
Nello Mainolfi, Nan Ji, Yi Zhang, Matthew M. Weiss
Filed: 21 Sep 18
Utility
IRAK degraders and uses thereof
28 Feb 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Matthew M. Weiss, Xiaozhang Zheng, Xiao Zhu
Filed: 17 Dec 20
Utility
CRBN ligands and uses thereof
29 Nov 22
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
Nello Mainolfi, Nan Ji, Arthur F. Kluge
Filed: 14 Jan 19
Utility
Protein degraders and uses thereof
1 Nov 22
The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
Nello Mainolfi, Nan Ji, Arthur F. Kluge
Filed: 14 Jan 19
Utility
STAT degraders and uses thereof
1 Nov 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Bin Yang, Yi Zhang
Filed: 6 Apr 20
Utility
CRBN ligands and uses thereof
14 Jun 22
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
Nello Mainolfi, Nan Ji, Yi Zhang, Matthew M. Weiss
Filed: 21 Sep 18
Utility
IRAK degraders and uses thereof
7 Jun 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
Filed: 2 Dec 19
Utility
IRAK degraders and uses thereof
3 May 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Arthur F. Fluge, Matthew M. Weiss, Yi Zhang
Filed: 16 Oct 20
Utility
Tricyclic CRBN ligands and uses thereof
5 Apr 22
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
Filed: 3 Jul 19
Utility
IRAK degraders and uses thereof
14 Sep 21
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
Filed: 18 Sep 20
Utility
IRAK degraders and uses thereof
28 Dec 20
The present invention provides compounds, compositions thereof, and methods of using the same.
Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
Filed: 20 Dec 18
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