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QSI Quantum-Si

APP
Utility
Methods and Compositions for Protein Sequencing
25 Nov 21
Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same.
Brian Reed, Manjula Pandey
Filed: 20 May 21
GRANT
Utility
Integrated device with external light source for probing detecting and analyzing molecules
23 Nov 21
System and methods for analyzing single molecules and performing nucleic acid sequencing.
Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid, Lawrence C. West, Keith G. Fife, Benjamin Cipriany, Farshid Ghasemi
Filed: 19 Nov 19
APP
Utility
Enrichment and Depletion of Target Molecules for Sequencing
18 Nov 21
Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein.
Jonathan M. Rothberg, John H. Leamon, Jonathan C. Schultz, Michele Millham, Caixia Lv, Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
Filed: 21 Apr 21
APP
Utility
Sample Preparation for Sequencing
18 Nov 21
Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein.
Jonathan M. Rothberg, John H. Leamon, Jonathan C. Schultz, Michele Millham, Caixia Lv, Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
Filed: 21 Apr 21
GRANT
Utility
Optical system and assay chip for probing, detecting and analyzing molecules
16 Nov 21
Apparatus and methods for analyzing single molecules and performing nucleic acid sequencing.
Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid, Paul E. Glenn, Lawrence C. West, Benjamin Cipriany, Keith G. Fife
Filed: 17 Jun 19
APP
Utility
Terminal Functionalization of Target Molecules for Sequencing
28 Oct 21
Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein.
Jonathan M. Rothberg, John H. Leamon, Jonathan C. Schultz, Michele Millham, Caixia Lv, Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
Filed: 21 Apr 21
APP
Utility
Integrated Sensor with Reduced Skew
14 Oct 21
Aspects of the present disclosure relate to techniques for reducing skew in an integrated device, such as a CMOS imaging device.
Eric A.G. Webster, Dajiang Yang, Xin Wang, Zhaoyu He, Changhoon Choi, Peter J. Lim, Todd Rearick
Filed: 7 Apr 21
APP
Utility
Integrated Sensor with Reduced Skew
14 Oct 21
Aspects of the present disclosure relate to techniques for reducing skew in an integrated device, such as a CMOS imaging device.
Eric A.G. Webster, Dajiang Yang, Xin Wang, Zhaoyu He, Changhoon Choi, Peter J. Lim, Todd Rearick
Filed: 7 Apr 21
APP
Utility
System and Methods for Electrokinetic Loading of Sub-micron-scale Reaction Chambers
7 Oct 21
Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described.
Guojun Chen, Jeremy Lackey, Alexander Goryaynov, Gerard Schmid, Ali Kabiri, Jonathan M. Rothberg, Todd Rearick, Jonathan C. Schultz, Farshid Ghasemi, Keith G. Fife
Filed: 17 Jun 21
GRANT
Utility
Method for isolating target nucleic acid using heteroduplex binding proteins
28 Sep 21
The invention includes methods and apparatus for separating mutations, especially rare and unknown mutations, using heteroduplex binding proteins.
Andrea Marziali, Milenko Despotovic, Matthew Wiggin, Joel Pel
Filed: 19 May 16
GRANT
Utility
Characterizing an optical element
21 Sep 21
A method and apparatus for characterizing an optical element.
Jonathan C. Schultz, Andrey V. Okishev, Craig Wenger, Brittany Lathrop, Faisal R. Ahmad
Filed: 15 Apr 19
APP
Utility
Pulsed Laser and Bioanalytic System
9 Sep 21
Apparatus and methods for producing ultrashort optical pulses are described.
Jonathan M. Rothberg, Jason W. Sickler, Lawrence C. West, Faisal R. Ahmad, Paul E. Glenn, Jack Jewell, John Glenn, Jose Camara, Jeremy Christopher Jordan, Todd Rearick, Farshid Ghasemi, Jonathan C. Schultz, Keith G. File
Filed: 7 May 21
GRANT
Utility
Integrated photodetector with direct binning pixel
7 Sep 21
An integrated circuit includes a photodetection region configured to receive incident photons.
Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
Filed: 15 Oct 20
APP
Utility
Integrated Sensor for Multi-dimensional Signal Analysis
2 Sep 21
Some aspects relate to an integrated circuit, comprising at least one photodetection region configured to generate charge carriers responsive to incident photons emitted from a sample, at least one charge storage region configured to receive the charge carriers from the photodetection region, and at least one controller configured to obtain information about the incident photons, the information comprising at least one member selected from the group comprising pulse duration and interpulse duration and at least one member selected from the group comprising wavelength information, luminescence lifetime information, and intensity information.
Gerard Schmid, Dajiang Yang, Eric A.G. Webster, Xin Wang, Todd Rearick, Changhoon Choi, Ali Kabiri, Kyle Preston, Brian Reed
Filed: 2 Mar 21
APP
Utility
Enrichment of Nucleic Acid Targets
5 Aug 21
Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.
Andrea Marziali, Milenko Despotovic, Joel Pel
Filed: 9 Apr 21
GRANT
Utility
System and methods for electrokinetic loading of sub-micron-scale reaction chambers
27 Jul 21
Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described.
Guojun Chen, Jeremy Lackey, Alexander Goryaynov, Gerard Schmid, Ali Kabiri, Jonathan M. Rothberg, Todd Rearick, Jonathan C. Schultz, Farshid Ghasemi, Keith G. Fife
Filed: 4 Jan 19
APP
Utility
Compounds and Methods for Selective C-terminal Labeling
22 Jul 21
The present disclosure relates to compounds and methods for selective C-terminal functionalization of peptides.
Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
Filed: 20 Jan 21
APP
Utility
Sensor for Lifetime Plus Spectral Characterization
15 Jul 21
Some aspects relate to integrated devices for obtaining timing and/or spectral information from incident light.
Gerard Schmid, Dajiang Yang, Eric A.G. Webster, Xin Wang, Todd Rearick, Changhoon Choi, Ali Kabiri, Kyle Preston
Filed: 14 Jan 21
APP
Utility
Waveguide Excitation Uniformity
15 Jul 21
Systems and methods for optical power distribution within an integrated device, in a substantially uniform manner, to a large number of sample wells and/or other photonic elements.
Gerard Schmid, Sharath Hosali, James Beach, Kyle Preston, Ali Kabiri, Bing Shen
Filed: 14 Jan 21
APP
Utility
Integrated Sensor for Lifetime Characterization
15 Jul 21
Aspects of the technology described herein relate to improved semiconductor-based image sensor designs.
Eric A.G. Webster, Changhoon Choi, Dajiang Yang, Xin Wang, Todd Rearick, Kyle Preston, Ali Kabiri, Gerard Schmid
Filed: 14 Jan 21
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