13 patents
Utility
Mek Inhibitors and Uses Thereof
30 Nov 23
The present disclosure provides MEK inhibitors, compositions thereof, and methods of using the same.
Alfredo C. CASTRO, Michael J. BURKE, Thomas A. WYNN, Sabine K. RUPPEL, Sergio L. SANTILLANA SOTO, Eric HAINES, Lan XU, Oksana ZAVIDIJ
Filed: 25 May 23
Utility
Aryl Hydrocarbon Receptor (Ahr) Agonists and Uses Thereof
21 Sep 23
The present invention provides AHR agonists, compositions thereof, and methods of using the same.
Alfredo C. CASTRO, Karen J. McGovern, Michael Burke
Filed: 9 Feb 23
Utility
Polymorphic Compounds and Uses Thereof
14 Sep 23
The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which the aryl hydrocarbon receptor (AHR) is implicated, by the administration of small molecule therapeutics which act as inhibitors of AHR.
Alfredo C. Castro, James Martin Nolan, III, Sarah Jean Bethune, Corinne Marie Folberth
Filed: 19 Jan 23
Utility
Tead Inhibitors and Uses Thereof
11 May 23
The present invention provides compounds, compositions thereof, and methods of using the same.
Alfredo C. CASTRO
Filed: 2 Aug 22
Utility
Ahr Inhibitors and Uses Thereof
9 Feb 23
The present invention provides methods for selecting a cancer patient who is AHR nuclear positive, and methods for treating cancer comprising selecting a cancer patient who is AHR nuclear positive, and administering to the patient an AHR inhibitor.
Marta SANCHEZ-MARTIN, Lei WANG, Xiaoyan Michelle ZHANG
Filed: 8 Jan 21
Utility
Indole Ahr Inhibitors and Uses Thereof
26 Jan 23
The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
Alfredo C. CASTRO, Catherine A. EVANS
Filed: 6 May 22
Utility
Ahr Inhibitors and Uses Thereof
26 Jan 23
The present invention provides AHR inhibitors, formulations and unit dosage forms thereof, and methods of use thereof.
Alfredo C. Castro, James Martin NOLAN, III, Xiaoyan Michelle ZHANG, Jason SAGER
Filed: 25 Nov 20
Utility
Tead Inhibitors and Uses Thereof
11 Aug 22
The present invention provides compounds, compositions thereof, and methods of using the same.
Alfredo C. CASTRO
Filed: 3 Jan 22
Utility
Indole Ahr Inhibitors and Uses Thereof
12 May 22
The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
Alfredo C. CASTRO
Filed: 16 Oct 19
Utility
Aryl Hydrocarbon Receptor (Ahr) Agonists and Uses Thereof
30 Sep 21
The present invention provides AHR agonists, compositions thereof, and methods of using the same.
Alfredo C. Castro, Karen J. McGovern, Michael Burke
Filed: 18 Dec 20
Utility
Polymorphic Compounds and Uses Thereof
19 Aug 21
The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which the aryl hydrocarbon receptor (AHR) is implicated, by the administration of small molecule therapeutics which act as inhibitors of AHR.
Alfredo C. CASTRO, James Martin NOLAN, III, Sarah Jean BETHUNE, Corinne Marie FOLBERTH
Filed: 25 Nov 20
Utility
Aryl Hydrocarbon Receptor (Ahr) Agonists and Uses Thereof
29 Jul 21
The present invention provides AHR agonists, compositions thereof, and methods of using the same.
Alfredo C. Castro, Karen J. McGovern, Michael Burke
Filed: 18 Dec 20
Utility
Pegylated Kynureninase Enzymes and Uses Thereof for the Treatment of Cancer
22 Apr 21
Kynureninase enzymes covalently bound to polyethylene glycol are described.
James NOLAN, Michelle ZHANG
Filed: 16 Oct 20
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